Ask about this productRelated genes to: INHBA antibody
- Gene:
- INHBA NIH gene
- Name:
- inhibin subunit beta A
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 7p14.1
- Locus Type:
- gene with protein product
- Date approved:
- 1986-01-01
- Date modifiied:
- 2018-04-23
Related products to: INHBA antibody
Related articles to: INHBA antibody
- Platinum resistance remains a major cause of treatment failure in ovarian cancer (OC). Cancer-associated fibroblasts (CAFs), key components of the tumor microenvironment, play critical roles in OC progression. Inhibin subunit beta A (INHBA) and its putative receptor endoglin (ENG) have been linked to OC chemoresistance, but their functional interaction in mediating cisplatin resistance remains unclear. - Source: PubMed
Publication date: 2026/07/11
Liu XinyueHan YanQin ZhichaoLi XinghuaSuo Yuping - Rathi cattle, an indigenous Bos indicus breed of north-western India, represent a valuable genetic resource due to their adaptation to arid environments, heat tolerance and dairy potential. However, genomic information on this breed remains limited. This study provides the first double-digest restriction-site associated DNA sequencing (ddRAD) based genome-wide assessment of Rathi cattle using a large sample size. A total of 96 animals were genotyped, generating 78,193 high-quality SNPs with 96.52% alignment to the Bos taurus (ARS-UCD2.0) reference genome, guaranteeing dependable variant identification. The population exhibited moderate genetic diversity with nucleotide diversity (π = 0.33 ± 0.09) and heterozygosity (Ho = 0.291 ± 0.084; He = 0.329 ± 0.104). Runs of homozygosity (ROH) made up 5.43% of the genome, and most of them were short segments (< 2 Mb), which shows that there hasn't been much inbreeding lately (F = 0.0512). Effective population size (Ne) declined from 1454 (150 generations ago) to 94 at present, highlighting the impact of demographic bottlenecks and genetic drift. The declining Ne suggests a risk of future genetic erosion, highlighting the need for effective conservation and breeding strategies. Population structure analyses (PCA, ADMIXTURE and STRUCTURE) revealed clear genetic distinctness of Rathi from other indigenous dairy breeds, despite its composite origin. Selection signature analyses (Tajima's D, CLR, ROH islands and iHS) identified candidate regions harboring genes associated with immunity (IL2RB, USP18), reproduction (INHBA, MEI4, HBA), lactation (LRRC8D, TRERF1, CCND3) and stress adaptation (CARHSP1, ITGAV). These findings are highlighting the valuable insights about diversity, demographic history and adaptive potential of rathi and offering genomic resources for conservation, sustainable utilization and genetic improvement programs. - Source: PubMed
Publication date: 2026/07/08
Bharia NishuBose AnalNayak Sonali SonejitaRajawat DivyaKumar VijayDutt TriveniPanigrahi Manjit - Acute lung injury (ALI) is a fulminant respiratory failure syndrome with no targeted therapy. We show that Inhba is sharply upregulated in the damaged lung tissue of mice and in BEAS-2B cells, and its abundance tracks with cytokine storm and reactive oxygen species (ROS). Mechanistically, AKT activation is associated with increased FOXA1 phosphorylation and abundance, which transcriptionally induce INHBA; this upregulation of INHBA is a key upstream driver of enhanced ROS production and cytokine release in experimental ALI. Genetic deletion or pharmacologic blockade of PI3K/AKT simultaneously lowered Foxa1 and Inhba, reduced TNF-α, IL-6, and ROS, and improved histologic injury scores and oxygenation. These findings establish the PI3K/AKT-Foxa1-Inhba axis as a central driver in experimental ALI models and support its potential as a druggable target for future investigation. Further validation in human ALI samples will be required to support clinical translation. - Source: PubMed
Liu YuanhuaLiu GuanghuiMei JingjingLi JiaSi JimingKang YanJin Jianjun - This study aimed to screen and identify osteoarthritis (OA)-related core immune genes, elucidate the mechanism underlying the temporal activation of key signaling pathways mediated by these genes, and screen potential therapeutic compounds, thereby providing a theoretical basis for the precision diagnosis and targeted intervention of OA. - Source: PubMed
Sun JiahaoSun QiChen YiqiangLi XinCui XuZhang YongkuiXie Wenpeng - Animal models of enhanced fertility are rare, as most genetically modified mouse models with reproductive phenotype display subfertility or infertility. Here, we describe the ovarian phenotype of the Dummerstorf line 2 (FL2) mouse strain, which exhibits high fertility and has been selectively bred for increased fertility over more than 190 generations. This long-term selection, outbred mouse line almost doubled the litter size to 21.5 (FL2) compared with 11.3 (unselected control line, ctrl), without showing any signs of growth retardation in the offspring. Here, we show that FL2 females ovulate 25.0 oocytes per cycle compared with 13.2 in ctrl. FL2 mice remain in the estrus phase for a shorter period during a 12-day observation period. Follicle-stimulating hormone (FSH) levels are decreased, both in estrus and diestrus, compared with ctrl, whereas luteinizing hormone levels are unaffected. The mRNA expression levels in the pituitary gland correspond to the gonadotropin levels in the blood. Progesterone levels are decreased in estrus in FL2. Hypothalamic expression levels of gonadotropin-releasing hormone (GnRH) are decreased in diestrus. Holistic gene expression analysis indicates complex and differential regulation in estrus and diestrus in ovaries of FL2 compared with ctrl. In particular, genes of the TGF-β pathway (such as Bmp3, Bmp7, and Inhba) and the Wnt pathway (such as Sfrp4 and Mkrn1) are differentially expressed in ovaries of FL2 females. These data indicate that reduced activity of the hypothalamic-pituitary-gonadal axis (in particular, lower levels of GnRH, FSH, and progesterone), combined with altered gene transcription in the ovaries, leads to higher ovulation rates in order to achieve the breeding objective of improved fertility. - Source: PubMed
Ludwig Carolin L MBohleber SimonBaufeld AnjaWirth Eva KLanghammer MartinaSchweizer UlrichMichaelis MartenWeitzel Joachim M