Ask about this productRelated genes to: IL10RB antibody
- Gene:
- IL10RB NIH gene
- Name:
- interleukin 10 receptor subunit beta
- Previous symbol:
- CRFB4, D21S58, D21S66
- Synonyms:
- CRF2-4, CDW210B, IL-10R2
- Chromosome:
- 21q22.11
- Locus Type:
- gene with protein product
- Date approved:
- 1993-04-06
- Date modifiied:
- 2019-04-23
- Gene:
- IL10RB-DT NIH gene
- Name:
- IL10RB divergent transcript
- Previous symbol:
- IL10RB-AS1
- Synonyms:
- IFNAR2-AS1
- Chromosome:
- 21q22.11
- Locus Type:
- RNA, long non-coding
- Date approved:
- 2013-05-17
- Date modifiied:
- 2018-03-23
Related products to: IL10RB antibody
Related articles to: IL10RB antibody
- The majority of lncRNAs' roles in tumor immunology remain elusive. This project performed a CRISPR activation screening of 9744 lncRNAs in melanoma cells cocultured with human CD8 T cells. We identified 16 lncRNAs potentially regulating tumor immune response. Further integrative analysis using tumor immunogenomics data revealed that and are significantly correlated with tumor immune response and survival in melanoma and breast cancer. Specifically, suppresses CD8 T cells activation via inhibiting IFN-γ-JAK-STAT1 signaling and antigen presentation in melanoma and breast cancer cells. On the other hand, 's up-regulation sensitizes the killing of tumor cells by CD8 T cells. Mechanistically, interacts and activates NF-κB component p65 to trigger the type I and type II interferon responses in melanoma and breast cancer cells. Our study systematically characterized novel lncRNAs involved in tumor immune response. - Source: PubMed
Publication date: 2022/12/07
Wang YifeiZhao YueshanGuo WeiweiYadav Ghanshyam SinghBhaskarla ChetanaWang ZehuaWang XiaofeiLi SihanWang YueChen YuangPattarayan DhamotharanXie WenLi SongLu BinfengKammula Udai SZhang MinYang Da - Renal cell carcinoma (RCC) is one of the most common aggressive malignant tumors in urogenital system, and the clear cell renal cell carcinoma (ccRCC) is the most common subtype of renal carcinoma. Immune related long non-coding RNAs (IRlncRs) plentiful in immune cells and immune microenvironment (IME) are potential in evaluating prognosis and assessing the effects of immunotherapy. A completed and meaningful IRlncRs analysis based on abundant ccRCC gene samples from The Cancer Genome Atlas (TCGA) will provide insight in this field. - Source: PubMed
Publication date: 2020/05/13
Jiang YuanbinGou XinWei ZongjieTan JianyuYu HaitaoZhou XiangLi Xinyuan