Ask about this productRelated genes to: IGHA1 antibody
- Gene:
- IGHA1 NIH gene
- Name:
- immunoglobulin heavy constant alpha 1
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 14q32.33
- Locus Type:
- immunoglobulin gene
- Date approved:
- 2001-06-22
- Date modifiied:
- 2014-11-19
Related products to: IGHA1 antibody
Related articles to: IGHA1 antibody
- Multiple myeloma (MM) is a heterogeneous hematological malignancy characterized by the clonal proliferation of plasma cells in the bone marrow, with distinct subtypes including smoldering MM (SMM), newly diagnosed MM (NDMM), and relapsed/refractory MM (RRMM). Despite therapeutic advances, outcomes remain unsatisfactory, especially for RRMM, due to unclear heterogeneity, progression mechanisms, and crosstalk between tumor cells and the bone marrow microenvironment (BMME) via direct interactions or extracellular vesicles (EVs). - Source: PubMed
Publication date: 2026/07/15
Fan LuZhao HanCong MengyaZhang MengxiaoRouzi TuerxunayiXie BeibeiDai JifeiBao Weiying - Metabolic dysfunction-associated steatotic liver disease (MASLD) is a complex, multifactorial condition. To achieve truly personalized therapy for MASLD, it will be essential to stratify patients based on clinical and biochemical data by identifying subgroups with distinct disease mechanisms and prognostic trajectories. - Source: PubMed
Publication date: 2026/07/15
Kimura TakefumiWakabayashi Shun-IchiIwadare TakanobuKondo ShoheiOkumura TaikiKobayashi HiroyukiYamashita YukiKamijo YumaFujita KaedeNakajima TomoyukiUchida TakuroYamazaki TomooIwaya MaiUehara TakeshiToyoda HidenoriKumada TakashiUmemura TakejiTanaka Naoki - Disulfidptosis is a novel form of glucose starvation-induced cell death, yet its prognostic implications in gastric cancer (GC) remain largely undefined. - Source: PubMed
Publication date: 2026/06/26
Xu YuxuanKong XianmingLi JinXiang Dongxi - Given the high incidence of epidural‑related maternal fever (ERMF) among women with epidural analgesia and the key roles of glycoproteins, an efficient nanoplatform is needed for N‑glycoproteomic analysis to better understand ERMF. Herein, we constructed an ultra-hydrophilic magnetic MXene-based nanoplatform (MMX-Cys) for efficient N-glycopeptide enrichment. By integrating the high surface area of MXene, the hydrophilicity of L-cysteine, MMX-Cys demonstrated ultra-hydrophilicity with a water contact angle of ~ 0°. It exhibits high sensitivity (1 fmol·µL⁻¹), excellent selectivity (HRP: BSA = 1:100), and good reproducibility in enriching glycopeptides from standard protein digests. Applied to plasma samples from ERMF patients and healthy controls, the MMX-Cys based nanoplatform enabled the identification of 1195 N-glycopeptides corresponding to 91 glycoproteins. Differential expression analysis revealed 18 significantly altered glycopeptides from 10 glycoproteins, predominantly involved in humoral immunity and complement activation, including immunoglobulin heavy chains (IGHG1, IGHG2, IGHA1, IGHA2) and complement component C2. This study presents an effective tool for N-glycopeptide determination and provides glycoproteomic evidence supporting the inflammatory pathogenesis of ERMF. The MMX-Cys based nanoplatform holds great potential in offering a foundation for future biomarker discovery and mechanistic studies. - Source: PubMed
Publication date: 2026/06/11
Xia ZiyeLi NingLiu ZhiqiangHu XufangDeng Chunhui - Class-switch recombination (CSR) allows B cells to produce antibodies with distinct effector functions, but its dynamics during a primary human response remain poorly understood. We sampled COVID-19-naive healthy volunteers every other day during the first 3 weeks after SARS-CoV-2 vaccination, combining bulk and single-cell B cell receptor repertoires, single-cell transcriptomics, immunophenotyping, and IGHC sterile transcript analysis. Vaccine-specific B cells show sterile transcription across all IGHC genes up to IGHG2, contradicting the prevailing idea of single-gene sterile transcription. Clonal tracking confirms that sequential CSR exists: e.g., IGHG3 to IGHG1 and IGHG1 to IGHA1 and IGHG2, with sparse switching beyond IGHG2. VDJ gene usage associates with specific isotype subclasses and differential CSR timing. CSR and somatic hypermutation are temporally decoupled, with antigen-specific clones remaining hypomutated up to 10 weeks post-immunization. These findings complement textbook models of CSR and inform strategies for vaccines requiring switching to key isotypes such as IgG1 or IgA2. - Source: PubMed
Publication date: 2026/06/04
Montamat-Garcia GuillemNg Joseph C FStewart Alexander TSinclair EmmaMensah Benedicta BGiam Yan HuiBlair PaulKateregga DianaGander AmirKipling DavidGuo DongjunServius LuteciaPiper Christopher J MBaig ZaraFraternali FrancaMauri ClaudiaDunn-Walters Deborah K