Ask about this productRelated genes to: IGF2BP2 antibody
- Gene:
- IGF2BP2 NIH gene
- Name:
- insulin like growth factor 2 mRNA binding protein 2
- Previous symbol:
- -
- Synonyms:
- IMP-2
- Chromosome:
- 3q27.2
- Locus Type:
- gene with protein product
- Date approved:
- 2006-02-09
- Date modifiied:
- 2015-11-23
Related products to: IGF2BP2 antibody
Related articles to: IGF2BP2 antibody
- Esophageal squamous cell carcinoma (ESCC) remains a therapeutic challenge, characterized by poor prognosis and limited treatments. Despite the established role of cancer stemness in progression and resistance, current stemness-targeting strategies, including Notch pathway inhibition, have shown suboptimal clinical efficacy. This study investigates the mechanistic role of METTL3-mediated m6A modification in ESCC stemness regulation and explores the therapeutic potential of combining METTL3 inhibitors with Notch blockade. - Source: PubMed
Publication date: 2026/06/11
Duan JingjingJin YingyingChen YueShi YinghuiWang HaotianBai MingWang FeixueYang YuchongGe ShaohuaZhu MinBa YiFan ZhongyiDeng Ting - [This corrects the article on p. 2948 in vol. 13, PMID: 37560007.]. - Source: PubMed
Publication date: 2026/05/25
Guan Xiao-QingYuan Xiao-NingFeng Kai-XiangShao You-ChengLiu QinYang Ze-LinChen Yan-YanDeng JinHu Mei-ShunLi JunTian Yi-HaoChu Meng-FeiZhang Jing-WeiWei Lei - Insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2) is an mRNA-binding protein implicated in tumorigenesis across multiple cancer types, but its functional role in oral squamous cell carcinoma (OSCC) remains incompletely understood. In this study, we combined bioinformatic analyses, validation in clinical specimens and cell lines, and functional experiments to investigate the role of IGF2BP2 in OSCC. IGF2BP2 was significantly elevated in OSCC and associated with poor overall survival. This upregulation was further validated in patient tissues and OSCC cell lines by quantitative real-time PCR, Western blot, and immunohistochemistry. IGF2BP2 knockdown markedly suppressed OSCC cell proliferation and migration in vitro and inhibited tumor growth in xenograft models in vivo. In parallel, IGF2BP2 depletion resulted in reduced phosphorylation of ERK and p38, supporting an association between IGF2BP2 and MAPK signaling activity in OSCC. In addition, immune-related pathway enrichment and immune infiltration analyses further suggested links between IGF2BP2 and the OSCC tumor immune microenvironment. Flow cytometric analysis of xenograft tumors revealed that IGF2BP2 knockdown altered macrophage-related immune features, including a reduced proportion of CD86 M1-like tumor-associated macrophages. Collectively, these findings support an oncogenic role for IGF2BP2 in OSCC and suggest that IGF2BP2 is associated with MAPK signaling and macrophage-related immune features in OSCC. - Source: PubMed
Publication date: 2026/05/18
Li JiajiaYue GuochaoZhao MingmingYan FenglianZhang HuiXiong HuabaoLi MinqiLiu Bo - Colorectal cancer (CRC) remains the third most common malignancy and a leading cause of cancer-related mortality worldwide. Despite immunotherapy advances, most CRCs respond poorly to immune checkpoint inhibitors due to their immunologically "cold" phenotype characterized by low immunogenicity and a suppressive tumor microenvironment. Oxidative stress has emerged as a critical determinant of antitumor immunity, with excessive reactive oxygen species (ROS) triggering immunogenic cell death, releasing tumor-associated antigens and damage-associated molecular patterns. However, endogenous mechanisms linking ROS regulation to innate immune activation remain incompletely understood. Here, we identify a previously unreported mitochondria-associated long non-coding RNA, lncRNA 606938, whose expression is inversely correlated with CRC progression. Mechanistically, lncRNA 606938 is exported from the nucleus via the HuR-IGF2BP2 complex and translocated to mitochondria through the mitochondrial targeting sequence and HMG2 domains of mitochondrial transcription factor A (TFAM). Within mitochondria, lncRNA 606938 enhances oxidative phosphorylation (OXPHOS) by upregulating mitochondrial DNA-encoded OXPHOS subunits, leading to excessive ROS production. In addition, lncRNA 606938 facilitates the recognition of N6-methyladenosine (mA) sites on TFAM mRNA by IGF2BP2, thereby enhancing its stability and expression, further reinforcing mitochondrial oxidative stress. The elevated ROS induces mitochondrial damage and cytosolic release of mitochondrial DNA, which activates the cGAS-STING pathway and stimulates innate immune responses, ultimately suppressing tumor growth. Collectively, our findings highlight lncRNA 606938 as a novel upstream regulator of mitochondrial metabolism and innate immune activation, providing new insights into lncRNA-mediated reprogramming of the tumor immune microenvironment and uncovering a potential therapeutic strategy to sensitize CRC to immunotherapy. - Source: PubMed
Publication date: 2026/06/06
Du Jin'eGuo ZhichaoLu QiaoGuo HuiqinLiu FengmingHao ZhaoyingDuan YiweiLi ZhuoyuWu Haili - Peptidyl arginine deiminase 4 (PAD4) catalyzes the deamination of arginine residues to citrulline, a post-translational modification known as citrullination, which regulates protein structure, function, and localization. Despite growing evidence connects PAD4 to cancer progression, its role in intrahepatic cholangiocarcinoma (ICC) remains largely unexplored. - Source: PubMed
Publication date: 2026/06/05
Tian GengZou LinZhang MinjieYe FangyuYe YutingYe YuchenPan DiLi JinxuanGuo YabingMao YuhanLi JiaChen JunDing YouxiangZhao Li