Ask about this productRelated genes to: IARS2 antibody
- Gene:
- IARS2 NIH gene
- Name:
- isoleucyl-tRNA synthetase 2, mitochondrial
- Previous symbol:
- -
- Synonyms:
- FLJ10326
- Chromosome:
- 1q41
- Locus Type:
- gene with protein product
- Date approved:
- 2005-05-09
- Date modifiied:
- 2014-11-19
Related products to: IARS2 antibody
Related articles to: IARS2 antibody
- Breast cancer represents the most common malignant tumor in women globally. Isoleucyl-tRNA synthetase 2 (IARS2), a member of the aminoacyl-tRNA synthetase family, promotes tumorigenesis across various cancers. Herein, the effects and mechanisms of IARS2 in breast cancer were investigated. IARS2 is upregulated in breast cancer tissues compared to normal tissues, correlating with the poor prognosis of patients with breast cancer. In order to knock down and overexpress IARS2, plasmids carrying short hairpin RNA targeting IARS2 and IARS2-overexpression plasmids were transfected into breast cancer cells, respectively. Our results demonstrated that silencing IARS2 repressed breast cancer cell progression. IARS2 deficiency attenuated tumor growth in MDA-MB-231 cell xenograft mouse models. Conversely, overexpression of IARS2 aggravated malignant cell behaviors in vitro and accelerated tumor growth in vivo. Mechanistically, IARS2 depletion stimulated ubiquitination-mediated degradation of β-catenin in breast cancer cells. Notably, the β-catenin inhibitor XAV-939 reversed IARS2-driven breast cancer malignant progression. Furthermore, differentially expressed genes were identified in IARS2-overexpressed breast cancer cells with or without XAV-939 in the light of mRNA-seq results. Overall, our findings uncovered that silencing IARS2 blocked the β-catenin signaling axis, thereby impeding breast cancer progression. IARS2 might become a promising novel therapeutic target for breast cancer intervention. - Source: PubMed
Publication date: 2026/07/12
Yang XiWang YaYi YanjiaoYang YangWang Hongjiang - Ovarian cancer (OC) remains one of the most lethal gynecological cancers worldwide. Despite advances in diagnosis, OC is mostly detected at late stages due to undefined symptoms. Therefore, identifying feasible, reliable, non-invasive biomarkers for early detection and disease stratification of OC is crucial. Tumor-educated platelets (TEPs) have emerged as a promising source for liquid biopsy, harboring oncogenic mRNA signatures that reflect the tumor microenvironment. In this study, we investigated TEP-mRNAs to identify stage-specific biomarkers for OC diagnosis and prognosis, while uncovering disease progression mechanisms and potential therapeutic targets. - Source: PubMed
Publication date: 2026/05/08
Gahin Shaimaa GamalIbrahim Mostafa SBadr Eman - Isoleucyl-tRNA synthetase 2 (IARS2) is a mitochondrial isoleucine-tRNA synthetase of the class I aminoacyl-tRNA synthetase family, and its role in cervical cancer remains poorly defined. Here, we report that IARS2 promotes cervical cancer cell proliferation and survival through regulation of the Rag GTPases and mTORC1. Elevated IARS2 expression was associated with poorer overall survival in patients with cervical cancer. Silencing of IARS2 significantly reduced cell viability and induced apoptosis in cervical cancer cells. Mechanistically, IARS2 inhibited mTOR degradation and sustained activation of the mTOR–eIF4E axis, thereby supporting cell proliferation. The amino acid–binding pocket of IARS2 was essential for these regulatory effects. Moreover, immunoprecipitation assays revealed that IARS2 interacted with Rag GTPases, particularly RagB and RagD. Together, these findings suggest that IARS2 may function as an amino acid sensor within the Rag–mTORC1 complex and highlight IARS2 as a potential therapeutic target in cervical cancer. - Source: PubMed
Publication date: 2026/03/02
Bi YuxinYe YuqinWu XufengCao HuangMa Quanfu - Our previous work established the AD-BXD mouse panel as an innovative model for studying the genetic complexity and heterogeneity underlying Alzheimer's disease (AD). In this study, we leveraged this model and proteomics approach to identify protein signatures linked to cognitive resilience in AD. - Source: PubMed
Chen YuStevenson Tamara KCao YidingFish Lauren ARobbins Julia EMerrihew Gennifer EPark JeaHohman Timothy JMacCoss Michael JKaczorowski Catherine C
- Source: PubMed