Ask about this productRelated genes to: HSD3B2 antibody
- Gene:
- HSD3B2 NIH gene
- Name:
- hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2
- Previous symbol:
- -
- Synonyms:
- SDR11E2
- Chromosome:
- 1p12
- Locus Type:
- gene with protein product
- Date approved:
- 1992-09-10
- Date modifiied:
- 2014-11-18
Related products to: HSD3B2 antibody
Related articles to: HSD3B2 antibody
- The RNA-binding protein Pumilio-2 (PUM2), encoded by PUM2, is known as a translational repressor with important roles during embryonic development, cell differentiation and synapse function. Information of its roles in the ovary were sparse, yet data bank mining followed by immunohistochemistry revealed expression in nonhuman primate ovarian granulosa cells (GCs). Expression was also found in human IVF-derived GCs, in samples of human GC tumors (GCT), and in KGN cells, a well-established GCT-derived cell line. KGN cells were used to explore the roles of PUM2. A small interfering RNA (siRNA) targeting PUM2 reduced PUM2 levels in KGN cells, as seen in a proteomic analysis, which also revealed that a total of 51 proteins were lower, and the abundance of 66 proteins were increased. GO term analyses showed that the pathways mainly decreased were 'response to virus', 'defence response to virus', and 'innate immune response'. PUM2 may thus be a regulator of the innate immune abilities of GCs. The pathway increased most was 'cell division', a result in line with increased proliferation of siRNA transfected KGN cells. This underlies the increased ability to close the gap in scratch assays, as individual cell velocity or directionality of migration were comparable to controls. Down-regulation of PUM2 also impaired the steroidogenic potential of KGN cells (lower HSD3B2 levels, lower progesterone in supernatant). Taken together, the results indicate fundamental roles of PUM2 not only in in the regulation of proliferation and steroidogenesis of human granulosa cells, but also in regulation of their innate immune abilites. - Source: PubMed
Publication date: 2026/06/17
Eubler KatjaHerrmann CarolaScholz LinaYuhao JiangBerg UlrikeBerg DieterDissen Gregory AMayr DorisPeitzsch MirkoForné IgnasiMayerhofer Artur - Congenital Adrenal Hyperplasia (CAH) is a group of diseases with an autosomal recessive inheritance pattern, which are caused by a defect in the enzymes involved in steroidogenesis in the adrenal cortex. Depending on the enzyme block variant, the spectrum of clinical manifestations of CAH varies from mild symptoms to potentially fatal disorders. The review provides a detailed analysis of the six main forms of CAH (lipoid hyperplasia, HSD3B2, CYP17A1, CYP21A2, CYP11B1, POR) with an in-depth description of their molecular basis, pathogenesis, and clinical and laboratory manifestations. Particular attention is paid to modern methods of genetic diagnosis of CAH, including analysis of the highly homologous CYP21A2 locus, prenatal and preimplantation diagnosis. Not only modern approaches to replacement therapy are described in detail, but also promising methods of treatment: corticotropin-releasing hormone receptor antagonists, gene- and cellbased technologies. The study's strength lies in its comprehensive analysis of the disease, spanning fundamental research to practical patient management, as applied to the realities of clinical practice in Russia. - Source: PubMed
Publication date: 2026/05/20
Vorontsova M VKokorina T SNuralieva N FYukina M YuTroshina E AMelnichenko G AMokrysheva N G - Soy isoflavones are phytoestrogens that exhibit both estrogenic and/or antiestrogenic effects. This research investigated the potential of soy isoflavones as functional feed additives to promote ovarian development in female Chinese mitten crabs (). One hundred ninety-two crabs (101.52 ± 4.57 g) were randomly assigned to four groups (six replicates per group and eight crabs per replicate), and fed diets supplemented with 0.00, 32.51, 70.83, or 369.03 mg/kg soy isoflavones for 11 weeks. Compared to the control group, supplementation with 32.51 mg/kg soy isoflavones significantly increased the gonadosomatic index, hemolymph vitellogenin content, and the mRNA levels in the hepatopancreas and ovary ( < 0.05). Moreover, supplementation with 32.51 and 70.83 mg/kg soy isoflavones significantly promoted yolk granule formation ( < 0.05). At the molecular level, soy isoflavones modulated estradiol levels and activated the estrogen-related receptor signaling. They also upregulated the expression levels of , , and genes ( < 0.05), compared to the control group. Additionally, they increased estradiol synthesis through activating the cyclic adenosine monophosphate/PKA/CREB protein signaling pathway. High dose supplementation (369.03 mg/kg) did not significantly affect ovarian development ( > 0.05). Therefore, soy isoflavones exhibit a U-shaped effect on ovarian development of , with 32.51 mg/kg being an effective dose for promoting ovarian maturation. - Source: PubMed
Publication date: 2026/03/14
He LongLi JinpingCao DexiangLiu ZhijunQin ChuanjieWang XiaodanQin JianguangLi ErchaoChen Liqiao - Di(2-ethylhexyl) phthalate (DEHP) is a high-production-volume plasticizer and ubiquitous environ-mental contaminant with established endocrine-disrupting potential. While zebrafish transcriptomic studies have typically used high concentrations and long exposure windows, less is known about genome-wide responses during late embryogenesis/early larval maturation under environmentally relevant exposures. Here we profiled whole-organism transcriptomic responses to a short DEHP exposure during a developmentally sensitive transition (96-120) hours post-fertilization, hpf) and interpreted responses using differential expression, enrichment analyses, and endocrine-focused protein-protein interaction (PPI) network modeling. - Source: PubMed
Publication date: 2026/02/25
Pais MariagiovannaMcCafferty KateCampos Guillermo LopezHardiman Gary - Rare subtypes of congenital adrenal hyperplasia (CAH) often present with heterogeneous and overlapping clinical features, leading to substantial diagnostic delays and misclassification. This study aimed to characterize the clinical, biochemical, and genetic profiles of rare CAH types in a Chinese cohort and to identify key diagnostic clues that support early differentiation of these uncommon forms. - Source: PubMed
Publication date: 2026/02/04
Chan KamGuo YingZhang ShaolingYan Li