Ask about this productRelated genes to: HSD3B2 antibody
- Gene:
- HSD3B2 NIH gene
- Name:
- hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2
- Previous symbol:
- -
- Synonyms:
- SDR11E2
- Chromosome:
- 1p12
- Locus Type:
- gene with protein product
- Date approved:
- 1992-09-10
- Date modifiied:
- 2014-11-18
Related products to: HSD3B2 antibody
Related articles to: HSD3B2 antibody
- Prostate cancer (PCa) is genetically a complicated disease with mediation by variations in genes coding for androgen biosynthesis and signaling genes. In the current study, we investigate the associations of key polymorphisms in the androgen pathway with serum testosterone and prostate-specific antigen (PSA) levels, while also exploring their potential functional impact using bioinformatics analyses. - Source: PubMed
Publication date: 2026/09/21
Ghorbani Vale Zaghard GhasemHaghi MehdiGhiamirad MehdiGhorbian SaeidEbrahimi Mehdi - Swainsonine (SW), the main toxic component of locoweed, can cause livestock poisoning and reproductive damage in male animals; however, the mechanism by which it affects testosterone secretion remains unclear. - Source: PubMed
Publication date: 2026/09/01
Chen ZhenxinZhou YukaiHe XiaodieLiu JiamingZhao YuLiu JiayueShi ShenghaoGou YucongHong JinYe DongyangGao Lei - A six-gene panel involved in androgen production, uptake, and conversion (APUC-6: , , , , , ) may define distinct clinical outcomes in metastatic prostate cancer. This study evaluated the prognostic and predictive value of APUC-6 expression in metastatic castration-sensitive prostate cancer (mCSPC). - Source: PubMed
Publication date: 2026/08/21
Shi XiaoleiShetty Amol CWang JareySong YangSutera Philip ADeek Matthew PPatel Krishnan RMadan Ravi ATang ChadProudfoot JamesDavicioni ElaiHussain ArifNguyen PaulSweeney ChristopherBoytim EllaLacuna Kristine PRyan Charles JAntonarakis Emmanuel STran Phuoc THwang Justin - The human gut microbiome plays a critical role in immune regulation, yet the molecular links between microbiome composition and host gene expression remain incompletely understood. We analyzed associations between host gene expression and microbiome composition in a cohort of 315 healthy individuals, integrating microarray-based gene expression data from three intestinal sites (ileum, transverse colon, and rectum) and six immune cell types with microbiome sequencing data. Using a hierarchical feature aggregation strategy combining principal component analysis, clustering, and covariate correction, we discovered significant associations primarily related to immunity. While microbial profiles were similar across the three intestinal sites, the transverse colon yielded the most "microbiome-host gene expression" associations. Among the immune cell types, CD8+ cells showed the highest number of associations. The first principal component of microbiome composition, reflecting a gradient from commensals (e.g., and ) to proinflammatory taxa ([] and ), correlated with the expression of TNF-α-linked genes (, , , and ). Among individual genera, abundance was associated with gene expression in both intestinal and immune cells, including negative associations with MRPS21 (related to mitochondrial function) in the transverse colon and with CD8+ gene programs related to T cell differentiation. These findings align with emerging evidence implicating mitochondrial dysfunction in intestinal inflammation. Our results identify multi-level associations between the gut microbiome and host gene expression, suggesting potential mechanisms by which microbiota shape local and systemic immunity and vice versa. The implicated genes and taxa represent candidates for experimental validation to improve understanding of host-microbiome homeostasis and its disruption in disease.IMPORTANCEThe gut microbiome and immune system are engaged in a complex interplay throughout human life. While most associative studies focus on case-control comparisons-typically examining patients with conditions such as inflammatory bowel disease or metabolic diseases-less is known about the molecular links between the microbiome and immune system in healthy individuals. In this study of a large cohort of healthy individuals, we addressed this gap by applying multiscale modeling to tackle the high dimensionality of host-microbiome data. We identified multi-level associations between microbiome composition and host gene expression in both intestinal tissues and immune cells. These findings offer a valuable reference for understanding baseline host-microbiome communication and highlight molecular candidates-such as TNF-α-related genes and mitochondrial pathways-for future experimental validation. - Source: PubMed
Publication date: 2026/08/10
Shagam Lev IElizarova AnnaMomozawa YukihideDmitrieva JuliaMariman RobRahmouni SouadLouis EdouardGeorges MichelTyakht Alexander VKlimenko Natalia - This study aimed to characterize phase-specific dynamics of androstenedione and estradiol across IVF/ICSI treatment, identify predictors of reproductive outcomes, and examine the effects of follicle-stimulating hormone (FSH), IGF1, and estradiol on steroidogenesis in human granulosa-like tumor (KGN) cells. In women undergoing IVF/ICSI (10 successful and 19 unsuccessful), serum hormones were measured before recombinant FSH stimulation (Phase 1) and during the mid-follicular (Phase 2) and ovulatory (Phase 3) phases, with follicular fluid (FF) collected at Phase 3. Mechanistic experiments were conducted in KGN cells (n = 3) treated for 24 h. Successful pregnancy was associated with greater increases in androstenedione and estradiol from Phase 2 to Phase 3 and higher Phase 3 steroid-to-basal gonadotropin ratios. Elevated Phase 1 androstenedione and estradiol were negatively correlated with the number of retrieved oocytes, mature oocytes, and/or embryos. Phase 3 serum androstenedione (cutoff ≥ 2.382 ng/mL; AUC = 0.708, P = 0.038) and FF aromatase (cutoff ≤ 0.378 ng/mL; AUC = 0.727, P = 0.007) predicted clinical pregnancy. In KGN cells, IGF1 stimulated early steroidogenesis (HSD3B2 mRNA expression and progesterone levels), FSH enhanced both early and late pathways (HSD3B2 and CYP19A1 mRNA expression together with progesterone, androstenedione, and aromatase levels), and supraphysiological estradiol suppressed downstream steroidogenesis (CYP19A1 mRNA expression and aromatase and progesterone levels). In conclusion, a favorable pattern with low early-follicular and high late-follicular androstenedione and estradiol was associated with IVF/ICSI success, whereas high early androstenedione and estradiol appeared detrimental. In KGN cells, supraphysiological estradiol without androgen substrate suppressed downstream steroidogenesis, consistent with the adverse effects of excessive early estradiol exposure, supporting granulosa cell contribution to local androgen availability. - Source: PubMed
Sririwichitchai RungnapaSitticharoon ChantachaKeadkraichaiwat IssarawanMaikaew PailinChanheng SuchawadeePetyim Somsin