Ask about this productRelated genes to: HRASLS5 antibody
- Gene:
- PLAAT5 NIH gene
- Name:
- phospholipase A and acyltransferase 5
- Previous symbol:
- HRASLS5
- Synonyms:
- HRLP5, iNAT, PLAAT-5
- Chromosome:
- 11q12.3
- Locus Type:
- gene with protein product
- Date approved:
- 2005-11-14
- Date modifiied:
- 2019-02-14
Related products to: HRASLS5 antibody
Related articles to: HRASLS5 antibody
- N-Acylethanolamines (NAEs) are a class of lipid mediators that exhibit anti-inflammatory and appetite-suppressive activities. Among them, palmitoylethanolamide (PEA) and arachidonoylethanolamide (AEA) bind to peroxisomal proliferator-activated receptor (PPAR) α and cannabinoid receptor CB1, respectively. N-Acyl-phosphatidylethanolamine (NAPE) as a precursor of NAEs is biosynthesized from membrane phospholipids by N-acyltransferases, which consist of group IVE cytosolic phospholipase Aε (cPLAε) and PLAAT (phospholipase A and acyltransferase) family enzymes. While cPLAε is responsible for the production of NAEs not only in specific tissues, including muscle, skin, and the stomach, but also under pathological conditions, such as psoriasis and brain ischemia, the involvement of the PLAAT family in vivo remains unclear. Considering the specific expression of PLAAT5 in testes, we investigated the potential role of PLAAT5 in the formation of NAEs in testes using PLAAT5-deficient (Plaat5) mice. High-performance liquid chromatography coupled with tandem mass spectrometry showed that PLAAT5 deficiency decreased the total level of NAEs by 61 %, with PEA and AEA being reduced by 64 % and 87 %, respectively. Following a treatment with cadmium chloride, an environmental toxin that induces testicular inflammation, the expression of inflammatory genes (Il6, Tnf, and Nos2) in testes was markedly higher in Plaat5 mice than in Plaat5 mice, and their expression was attenuated by the administration of PEA and AEA. Furthermore, these anti-inflammatory effects were canceled by a co-treatment with the antagonists of PPARα or CB1. These results suggest that PLAAT5 is responsible for the biosynthesis of anti-inflammatory NAEs in testes. - Source: PubMed
Publication date: 2024/11/26
Sikder Mohammad MamunSasaki SumireMiki YoshimiNagasaki YukiOhta Ken-IchiHussain ZahirSaiga HiroyukiOhmura-Hoshino MariHoshino KatsuakiUeno MasakiOkada-Iwabu MikiMurakami MakotoUeda NatsuoUyama Toru - To clarify the genetic role of phospholipase A2 (PLA2) genes in Parkinson's disease (PD), we performed a genetic association study in large Chinese population cohorts using next-generation sequencing. In this study, we analyzed both rare and common variants of 38 phospholipase A2 genes in two large cohorts. We detected 1558 and 1115 rare variants in these two cohorts, respectively. In both cohorts, we observed suggestive associations between specific subgroups and the risk of PD. At the single-gene level, several genes (PLA2G2D, PLA2G12A, PLA2G12B, PLA2G4F, PNPLA1, PNPLA3, PNPLA7, PLA2G7, PLA2G15, PLAAT5, and ABHD12) are suggestively associated with PD. Meanwhile, 364 and 2261 common variants were identified in two cohorts, respectively. Our study has expanded the genetic spectrum of the PLA2 family genes and suggested potential pathogenetic roles of PLA2 superfamily in PD. - Source: PubMed
Publication date: 2024/05/14
Liu JiabinWang YigeZhao YuwenPan HongxuLiu ZhenhuaXu QianLu ShenJiang HongWang JunlingSun QiyingTan JieqiongYan XinxiangLi JinchenTang BeishaGuo Jifeng - The phospholipase A and acyltransferase (PLAAT) family of cysteine hydrolases consists of five members, which are involved in the Ca-independent production of -acylphosphatidylethanolamines (NAPEs). NAPEs are lipid precursors for bioactive -acylethanolamines (NAEs) that are involved in various physiological processes such as food intake, pain, inflammation, stress, and anxiety. Recently, we identified α-ketoamides as the first pan-active PLAAT inhibitor scaffold that reduced arachidonic acid levels in PLAAT3-overexpressing U2OS cells and in HepG2 cells. Here, we report the structure-activity relationships of the α-ketoamide series using activity-based protein profiling. This led to the identification of , a nanomolar potent inhibitor for the PLAAT family members. reduced the NAE levels, including anandamide, in cells overexpressing PLAAT2 or PLAAT5. Collectively, may help to dissect the physiological role of the PLAATs. - Source: PubMed
Publication date: 2020/08/13
Zhou JuanMock Elliot DAl Ayed KarolDi XinyuKantae VasudevBurggraaff LindseyStevens Anna FMartella AndreaMohr FlorianJiang Mingvan der Wel TomWendel Tiemen JOfman Tim PTran Yvonnede Koster Nickyvan Westen Gerard J PHankemeier Thomasvan der Stelt Mario - We analyzed the gene expression of Ha-ras suppressor family member 5 (Hrasls5), which is considered to modulate the Ha-ras signaling cascade, from maturing rat testis. Expression was detected primarily in the spermatocytes in the maturing rat testis. The Hrasls5 gene product might function as a tumor suppressor as well as in spermatogenesis, as deduced from its amino acid sequence. - Source: PubMed
Publication date: 2008/05/07
Yamano YoshiakiAsano AtsushiOhyama KenjiOhta MasanoriNishio RenMorishima Isao