Ask about this productRelated genes to: HEXA antibody
- Gene:
- HEXA NIH gene
- Name:
- hexosaminidase subunit alpha
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 15q23
- Locus Type:
- gene with protein product
- Date approved:
- 2001-06-22
- Date modifiied:
- 2016-10-05
Related products to: HEXA antibody
Related articles to: HEXA antibody
- This study provides a comparative analysis of concentrations and spatial distribution patterns of DDT (including its metabolites) and polychlorinated biphenyls (PCBs) in bottom sediments from three rivers with contrasting environmental and anthropogenic settings: the Salgir (Russia), the Asi (Orontes, Syrian Arab Republic), and the Fatala (Republic of Guinea). Surface and sediment-core samples collected in 2023 revealed substantial spatial heterogeneity in POPs contamination. In the Salgir River, ∑DDT concentrations reached up to 562 ng/g, with DDT/DDE ratios > 0.79 indicating recent inputs, likely from legacy pesticide storage sites. ∑6PCB concentrations (sum of six indicator congeners) reached 252 ng/g, with evidence of ongoing inputs in industrial zones. The Asi River exhibited the highest ∑6PCB levels (up to 863 ng/g), particularly near industrial facilities, with a congener profile dominated by highly chlorinated forms (hexa- to octachlorobiphenyls), consistent with technical PCB mixtures. The distribution of these contaminants is primarily associated with long-term significant anthropogenic loads of various nature in the Asi River region, although identifying direct sources of PCBs entering the ecosystem of the river requires additional research. The Fatala River showed minimal contamination (∑6PCB < 2.6 ng/g; DDTs below detection limits), reflecting background conditions. Sediment-core profiles confirmed historical PCB contamination peaks in the Salgir River corresponding to the 1960s-1990s, based on established geochronology, and indicated continued PCB accumulation in surface layers of both the Salgir and Asi rivers. Comparison with national and international sediment quality guidelines indicates that the observed contamination levels in the Salgir and Asi rivers substantially exceed ecologically safe values, highlighting their potential impact on the ecosystem. - Source: PubMed
Publication date: 2026/05/04
Malakhova LudmilaMirzoeva NatalyaVoitsekhovskaia VeronikaMalakhova TatyanaMironov OlegDiallo Alpha Issaga PalleKeita IbrahimaHadid MahmoudSalameh Maan - High-nuclearity molybdenum blue (MB) clusters with regular lacunary variation are of great importance for polyoxometalate structure evolution and photocatalytic application study, but their synthesis still remains a huge challenge. Herein, we successfully synthesized a series of high-nuclearity MB clusters, SMo, SMoW, MoW, and MoW, which exhibit regular lacunary variation. More importantly, such structural variation endows these MB clusters with distinct Lewis acidity and redox properties. Consequently, when employed as heterogeneous photocatalysts for the chemodivergent C─C coupling reactions between 1,3-diketones and alkenes, the hexa-lacunary MoW and MoW with more Lewis acid sites can achieve a 93% 1,5-diketone yield within 12 h, while parent SMo with superior oxygen activation can achieve a 99% 1,4-diketone yield within 3 h. Furthermore, MoW enables gram-scale and sunlight driven synthesis of diverse 1,5-diketone, and maintains long-term cycling stability over 370 h (16 cycles). This work represents the first report of high-nuclearity MB clusters with regular lacunary variation, and extends their application to sunlight driven photocatalytic C─C coupling reaction, highlighting the innovative research of MB clusters. - Source: PubMed
Publication date: 2026/05/04
Kuang YiMei Zhi-BinLin Jiao-MinZeng ChengDong Long-ZhangLiang Shao-HuaShi Jing-WenJin LuLi Shun-LiLiu JiangLan Ya-Qian - Buckybowls, the curved fragments of fullerenes, are attractive synthetic targets for exploring carbon nanomaterials, but constructing atomically well-defined, large multilayered architectures remains a formidable challenge. Here we report the synthesis of a class of coronene-bottomed nanographenic bowls, namely, tricarbon-annulated trifluorenocoronenes (TCTFCs), based on a contorted hexa--hexabenzocoronene (-HBC) skeleton. Two TCTFC derivatives bearing -diaryl or -dialkyl appendages were prepared via a "branching arms cyclization" (BAC) strategy. X-ray crystallography unambiguously confirms their C-symmetric bowl-shaped geometry with bowl depths up to 2.3 angstrom and diameters exceeding 1 nanometer. These bowls exhibit red-shifted absorption/emission profiles, enhanced electron affinity, and reduced aromaticity relative to the -HBC derivative. Notably, both compounds form 1:1 complexes with C in solution, while their cocrystals adopt columnar or honeycomb packing motifs. This work establishes a synthetic paradigm in constructing fully edge-closed -HBC-based buckybowls, further delivering fundamental insights into their substituent-dependent host-guest binding and supramolecular assembly. - Source: PubMed
Publication date: 2026/05/01
Sun YixunYang BoJia MinGuo JingWang YitingHu JialeXu XinLiang QingxiangDang JingshuangFan JuanLi JingSun HuamingWei Junfa - Cardiovascular disease (CVD) is a major complication in patients with metabolic syndrome (MetS). The risk of CVD is influenced by genetic, sociodemographic, and lifestyle factors. - Source: PubMed
Publication date: 2026/05/01
Lee HaejungLee DaeEunJun Sukhyun - Lipomannan (LM) and lipoarabinomannan (LAM) are important components of the cell envelope of all mycobacteria that have been extensively studied for their roles in mycobacterial physiology and host-pathogen interactions. Despite the considerable progress made in deciphering the structure and biosynthesis of these lipoglycans over the last few decades, some of the key steps leading to their assembly and export to the cell surface remain ill-defined. We report on the characterization of a conserved and essential polyprenyl phosphate mannose-dependent mannosyltransferase named MptB, involved in the initial steps of the elongation of the mannan domain of LM and LAM from a phosphatidylinositol mannoside (PIM) anchor. Genetic silencing of mptB in Mycobacterium smegmatis led to the arrest of LM, LAM and PIM synthesis beyond di-mannosylated forms of these glycolipids. In cell-free assays, mptB overexpression led to the increased production of tetra-mannosylated forms of PIMs by M. smegmatis membranes, whereas reduced mptB expression resulted in the dramatically decreased synthesis of phosphatidylinositol tri-, tetra- and hexa-mannosides. Together with structural modeling predictions, the results of these assays support MptB as the α-(1,6)-mannosyltransferase elongating the mannan backbone of LM from a di- and/or tri-mannosylated PIM primer. - Source: PubMed
Publication date: 2026/04/27
Šarkan MichalForbak MartinBrown Chelsea MGilleron MartineAngala Shiva KDe KavitaTymčuková ViktóriaGašparovič HenrichGuerin Marcelo ENigou JérômeMikušová KatarínaStansfeld Phillip JJackson MaryKorduláková Jana