Ask about this productRelated genes to: HEPH antibody
- Gene:
- HEPH NIH gene
- Name:
- hephaestin
- Previous symbol:
- -
- Synonyms:
- KIAA0698, CPL
- Chromosome:
- Xq12
- Locus Type:
- gene with protein product
- Date approved:
- 1999-05-07
- Date modifiied:
- 2016-10-05
Related products to: HEPH antibody
Related articles to: HEPH antibody
- This study investigated the effects of a topical cannabidiol (CBD) gel compared to placebo on muscle function recovery, perceived muscle soreness, and blood marker of muscle damage following strenuous exercise designed to induce muscle damage. - Source: PubMed
Publication date: 2026/03/25
Mendes AntoineCuvelier GregoryAnthierens AgatheLocquenies AppolineGauchet NathanMaboudou PatriceHeyman ElsaBerthoin SergeGamelin François-Xavier - The simultaneous quantification of multiple analytes in complex biological matrices represents a critical bottleneck for deciphering metabolic reprogramming in translational research. In this paper, a two-working-electrode cellular electrochemical platform (TWECP) was developed for the simultaneous determination of adenine (A) and hypoxanthine (H). The platform integrates two spatially isolated functional electrodes: A-functional electrodes (A-FE) and H-functional electrodes (H-FE). These electrodes were fabricated by coating molecularly imprinted polymer-grafted multi-walled carbon nanotubes (MWCNTs@A-MIPs and MWCNTs@H-MIPs) onto glassy carbon electrodes and were connected to independent signal transduction channels. The A or H template-to-functional monomer ratio was optimized to 1:3, maximizing selectivity via hydrogen bonding interactions. TWECP achieved complete DPV peak height signal isolation for A ( = 1.03 V vs Ag/AgCl) and H ( = 1.068 V vs Ag/AgCl) within physiological concentration ranges (A: 0.4-30 μM; H: 1-30 μM) (DPV peak potentials were measured with 10 mV accuracy), with detection limits of 0.26 μM (A) and 0.20 μM (H) (S/N = 3). The platform exhibited negligible crosstalk and recoveries of 95.83-104.17% for cellular A and H detection. Strong linear correlations were established between intracellular A and H signals and MCF-7 cell densities (1.0-8.5 × 10 cells mL). Crucially, TWECP detected metabolic shifts indicative of entry into the log phase 48 h earlier than traditional cell counting. Synchronous A and H dynamics revealed distinct purine metabolic reprogramming, from which it was inferred that cell entry into the decline phase was suggested to be driven by external factors rather than apoptosis. This study establishes a crosstalk-free method for multiplex metabolite monitoring, and this high-temporal-resolution decoding of purine flux provides mechanistic insights into cancer metabolic adaptation. - Source: PubMed
Publication date: 2026/02/13
Zhang ShumengZhao MingWang FangzhenLuo XiaociYu ZhileTang DaweiYang YangHuang PeiJiang XueyanZhang JianyeHe Gen - Pearl culture has long been a major global industry. As a significant global producer, China mainly produces pearls from the freshwater mussel (). with various shell colors can produce pearls of different colors; for example, mussels with a blue-white shell can produce white pearls, while those with a purple shell can produce light-purple pearls. Therefore, investigating the molecular genetics of shell color variation in can advance our understanding of the mechanisms underlying differences in shell and pearl coloration in these mussels. In this study, we selected juvenile with four differently colored inner shells and collected tissue samples for transcriptomic analysis. The results showed that many key genes involved in the regulation of pigment metabolism (such as ADAMTS, TYR, BCDO2, and FTH1), as well as those associated with metabolism and mineral absorption (such as TRPV6, HCP1, HEPH, and Zip4), exhibited significant differences. Furthermore, these DEGs (differentially expressed genes) may influence the synthesis and metabolism of melanin, carotenoids, porphyrins, and heme, thereby affecting shell color variation; they might also be one of the potential reasons why produces pearls of different colors. - Source: PubMed
Publication date: 2026/01/29
Huang FuyongJiang QinghuaXing JubinXu YongbinYang QingmanTang JinyuTang ZengpingLiang XiaoZhu ShaohuaLou Bao - Based on previous evidence indicating the gastroprotective potential of Hericium erinaceus polysaccharides (HEP), this study aimed to evaluate their protective effects against ethanol-induced gastric ulcers in mice and characterize the associated serum metabolic changes using an untargeted metabolomics approach. Determinations of gastric ulcer severity, biochemical indicators, and serum metabolites in mice showed that intragastric administration of HEP reduced ulcer severity. Serum tests confirmed its regulatory effects on oxidative stress and inflammatory markers. Gastric tissue analysis revealed that HEP modulated mucosal barrier integrity and apoptotic pathways. Untargeted metabolomics analysis demonstrated significant differences in serum metabolites among experimental groups. A total of 11 disrupted metabolic pathways were associated with ulcer induction (UC vs NC). In contrast, in mice treated with HEP (HEPh group vs NC), 4 metabolic pathways were significantly altered, namely one‑carbon metabolism via folate, cysteine and methionine metabolism, nicotinate and nicotinamide metabolism, and glycerophospholipid metabolism. Changes in these pathways were associated with improvements in indicators related to oxidative stress status, inflammatory responses, and gastric mucosal repair. This study is the first to systematically analyze serum metabolite changes following HEP intervention in an ethanol-induced gastric ulcer model. The findings provide metabolomic insights into the potential protective effects of HEP and highlight candidate metabolic pathways for further targeted validation. - Source: PubMed
Publication date: 2026/02/01
Gao XinWang WenxuZhang JinlongHou JingboLiu Chao - This study investigated the effects of fluoxetine on noise-induced injuries to the cochlea and auditory nerve, with a focus on its impact on perineuronal nets (PNNs) and gene expression changes in the ventral cochlear nuclei (VCN). - Source: PubMed
Publication date: 2026/02/03
An Hyun-JuChoi SujinLee SoonchulYeo HyunjeongKim So Young