CD43
- Known as:
- CD43
- Catalog number:
- 10-220-C100
- Product Quantity:
- 0.1 mg
- Category:
- -
- Supplier:
- Exbio
- Gene target:
- CD43
Related genes to: CD43
- Gene:
- SPN NIH gene
- Name:
- sialophorin
- Previous symbol:
- -
- Synonyms:
- LSN, CD43, GPL115
- Chromosome:
- 16p11.2
- Locus Type:
- gene with protein product
- Date approved:
- 1988-08-31
- Date modifiied:
- 2016-07-19
Related products to: CD43
Related articles to: CD43
- Dopamine signaling in the striatum is essential for a wide range of functions, from reward learning to motor vigor and behavioral flexibility. Although dopamine signals fluctuate on sub-second timescales, how these signals are translated into lasting changes in striatal circuit function remains unknown. Resolving this requires cell-type-specific measurements of synaptic and intrinsic properties during behavior, a longstanding technical challenge. Here, we combined whole-cell membrane potential recordings, simultaneous monitoring and bidirectional manipulation of dopamine signaling in awake, behaving mice to examine how dopamine shapes corticostriatal circuits. Acute manipulations of dopamine over seconds to minutes produced only modest effects on corticostriatal synaptic transmission and no detectable changes in membrane potential dynamics or intrinsic excitability. By contrast, associative learning robustly strengthened identified corticostriatal synapses onto both D1- and D2-expressing spiny projection neurons, yet only D1-SPN plasticity required dopamine signaling. These findings challenge models in which dopamine acts rapidly to tune striatal excitability and identify learning related plasticity as its principal mechanism for shaping striatal circuits . - Source: PubMed
Publication date: 2026/08/06
Druart MélanieYang Yun CTritsch Nicolas XSippy Tanya - Spinal projection neurons (SPNs) relay somatosensory information to the brain, yet how molecularly defined SPN subsets transmit noxious mechanical signals to drive nocifensive behaviors remains unclear. Here, we identify -expressing SPNs ( SPNs) that convey noxious mechanical signals through a spinoreticular ascending pathway. Using intersectional genetics, anatomical tracing, and pathway-specific manipulations in mice, we show that SPNs project predominantly to the parabrachial nucleus and the lateral reticular nucleus (LRN). Functional analyses reveal that spinoreticular pathway transmits noxious mechanical information. LRN neurons receiving spinal input are required for nocifensive behaviors elicited by noxious mechanical stimulation and contribute to mechanical allodynia of neuropathic pain. Monosynaptic tracing identifies local interneurons innervating SPNs, providing a substrate for spinal gating of ascending mechanical signals. These findings highlight a spinoreticular circuit involving the LRN that is essential for nocifensive behaviors to noxious mechanical stimuli. - Source: PubMed
Publication date: 2026/08/19
Liu YuanLi QingLin Jun-KaiHan YifeiYang XiaoyuXu ZiningZhou WanqiuSun Yan-GangDou Yan-Nong - Retroperitoneal paraganglioma (RPGL) is an uncommon extra-adrenal neuroendocrine tumor. When located adjacent to the pancreas, RPGL may mimic solid pseudopapillary neoplasm of the pancreas (SPN/SPTP) because both lesions may present as large cystic-solid masses with nonspecific symptoms and non-diagnostic conventional tumor markers. Percutaneous biopsy may establish the diagnosis but can be hazardous when RPGL has not been excluded. - Source: PubMed
Publication date: 2026/08/04
Song JiaqiSun WeiRen YingzhengDeng FuyangZhang Guixin - Although second near-infrared (NIR-II) photoacoustic (PA) imaging affords deep tissue penetration, developing efficient contrast agents remains challenging due to a lack of suitable optical absorbers. Herein, we report semiconducting polymer nanoparticles (SPNs) for dual-modal PA and NIR fluorescence imaging, featuring a high optical absorption coefficient at 1064 nm that facilitates excitation via high-power Nd:YAG lasers. Phantom evaluations revealed a linear PA signal correlation, with a low detection limit of 0.05 cm. In vivo studies in tumor-bearing mice demonstrated passive SPN accumulation in tumor tissue, successfully visualized by both PA and NIR fluorescence imaging. These results indicate that SPNs are promising contrast agents for dual-modal imaging. - Source: PubMed
Publication date: 2026/07/24
Hirasawa TakeshiSato TakahiroAkasaka SayaYoshimoto YuyaIshikawa TomohiroShintate RyoMiyashita ManamiTsubata YoshiakiSaito KouichiIshihara Miya - Pancreaticoduodenectomy (Whipple procedure) is rarely required in children, but remains the standard of care for resectable pancreatic head tumors. Robotic pancreaticoduodenectomy (RPD) has been increasingly performed in adults, demonstrating safety, feasibility, and in some series, superior perioperative outcomes compared with open surgery. In children, however, there are only three published case reports worldwide. - Source: PubMed
Publication date: 2026/08/16
Zamora Irving JSims Jessica KGupta Vikas SD'Cruz Roshan JJacobson JillianChara Alejandro OJohnson Kevin NGamboa Anthony MBenedetti Daniel JPolanco Patricio MZeh Herbert JPadmanaban SekharLovvorn Harold NPandya Samir