Ask about this productRelated genes to: HDAC4 antibody
- Gene:
- HDAC4 NIH gene
- Name:
- histone deacetylase 4
- Previous symbol:
- BDMR
- Synonyms:
- KIAA0288, HDAC-A, HDACA, HD4, HA6116, HDAC-4
- Chromosome:
- 2q37.3
- Locus Type:
- gene with protein product
- Date approved:
- 2000-11-28
- Date modifiied:
- 2015-09-11
Related products to: HDAC4 antibody
Related articles to: HDAC4 antibody
- Ketogenic diets (KD) recapitulate certain metabolic aspects of dietary restriction such as reliance on fatty acid metabolism and production of ketone bodies. This study aimed to investigate whether a KD might, like dietary restriction, affect brain functions in epilepsy. - Source: PubMed
Publication date: 2025/07/02
An WenXing MengnanFan WeiZheng KaiyueXu Xiangping - Asian soybean rust (ASR), caused by Phakopsora pachyrhizi, remains difficult to control because resistance has reduced the effectiveness of several major fungicide classes. In this study, we designed 1,2,4-oxadiazole derivatives bearing tetrazolinone or triazolinone fragments through fragment recombination and then explored the putative target-binding characteristics of the lead compound by computational methods. - Source: PubMed
Publication date: 2026/05/10
Meng FanqiLiu YuandongDu XiaowenTian LeiZhang JingZhang Lixin - Early recurrence after curative resection remains a major challenge in hepatocellular carcinoma (HCC), particularly in hepatitis B virus (HBV)-related cases. Liquid biopsy using circulating microRNAs (miRNAs) offers a non-invasive approach to identify molecular markers predictive of recurrence. - Source: PubMed
Publication date: 2026/05/06
Kim Sang-HoonLee RyunjinTak EunyoungKim Ki-Hun - Low vitamin D levels during pregnancy are associated with an increased risk of Gestational Diabetes Mellitus (GDM), potentially mediated by altered vitamin D metabolism. Cytochrome P450 family 24 subfamily A member 1 (CYP24A1) plays a key role in vitamin D catabolism, but its epigenetic regulation in GDM remains unclear. - Source: PubMed
Publication date: 2026/05/06
Milan K LAnuradha MRamkumar K M - Central nervous system (CNS) injury is a leading cause of death and long-term disability worldwide. Neurological deficits reflect disruption of central neural circuits. A major barrier to circuit repair is the intrinsically low regenerative potential of adult CNS neurons-linked in part to failure of injury-induced nuclear export of class IIa histone deacetylases (notably HDAC5)-together with a hostile post-injury microenvironment. Here we present a multifunctional nanosystem, encapsulating the class IIa HDAC4/5-selective inhibitor LMK-235 and featuring an electroactive polyaniline coating with asymmetrically distributed 5-hydroxytryptamine moieties. Upon reaching the lesion, our nanosystem assembles into large-pore scaffolds that (i) inhibit the activity of nuclear-retained class IIa HDACs in neurons and thereby reactivate intrinsic regenerative programs, (ii) regulate microglial activation to mitigate neuroinflammation, and (iii) provide an electroactive interface promoting activity-dependent synaptic reconnection. This multi-pronged approach illustrates an integrated platform with translational potential for CNS disorders in which circuit disconnection constrains recovery. - Source: PubMed
Publication date: 2026/05/04
Tong ShiqiangYe ShuaiMa FenfenXie XiaoyingSun YinzheMa ChuchuShi TiantianCheng ZhengLi ChangHan WeiliXie LaozhiZhou SongleiGong JianingHuang ChenHuang YukunJiang GanLiu XiaolinLi BingZeng FengGong JingruWang ZhihuaGao XiaolingMei QiyongLi Wei-GuangChen Jun