Ask about this productRelated genes to: HBE1 antibody
- Gene:
- HBE1 NIH gene
- Name:
- hemoglobin subunit epsilon 1
- Previous symbol:
- -
- Synonyms:
- HBE
- Chromosome:
- 11p15.4
- Locus Type:
- gene with protein product
- Date approved:
- 2001-06-22
- Date modifiied:
- 2016-10-05
Related products to: HBE1 antibody
Related articles to: HBE1 antibody
- Chemotherapy resistance remains a major challenge in pancreatic cancer treatment, with gemcitabine-based therapy being a primary approach. However, the mechanisms underlying gemcitabine resistance in pancreatic cancer cells are not yet fully understood. This study aimed to investigate the role ofHBE1in conferring resistance to gemcitabine and explore its effects on reactive oxygen species (ROS) production, mitochondrial apoptosis, and endoplasmic reticulum (ER) stress. - Source: PubMed
Publication date: 2026/03/14
Cheng JiyunJiang HaixingYu XianenHuang PeiningLu YihanTan ShudanLiu XiaojunQin Shanyu - The genetic basis for Tibetan sheep adaptation to different high-altitude environments remains unknown. This study conducted whole-genome resequencing on 80 Tibetan sheep individuals from four major distribution areas on the Qinghai-Tibet Plateau. Based on the high-quality single-nucleotide polymorphisms (SNPs) obtained, an analysis of population-level genomic selection signals was performed. Population genomic analysis revealed that Tibetan sheep distributed across China originated in northern China but showed evidence of gene flow from South Asian sheep. Between populations from extremely high-altitude and mid-altitude regions, selection analyses identified five strongly positive selected genes ( [Hypoxia Inducible Factor 1 Alpha Subunit Inhibitor], [Hemoglobin Subunit Epsilon 1], [Hemoglobin Subunit Epsilon 2], [TNF Alpha Induced Protein 3], [RAD50 Double Strand Break Repair Protein]). These genes are associated with adaptation to hypoxia and intense UV radiation in high-altitude environments. Selection analyses between populations from extremely high-altitude and mid-altitude regions identified five strongly selected genes ( [Hypoxia Inducible Factor 1 Alpha Subunit Inhibitor], [Hemoglobin Subunit Epsilon 1], [Hemoglobin Subunit Epsilon 2], [TNF Alpha Induced Protein 3], [RAD50 Double Strand Break Repair Protein]) associated with hypoxia and intense UV radiation in high-altitude environments. Comparative genomic analyses of populations in cold and arid environments identified several candidate genes related to energy and water homeostasis, as well as hair development ( [Tumor Protein P53], [Autophagy Related 101], [ATPase H+/K+ Transporting Non-Gastric Alpha2 Subunit], [Keratin 80], [Keratin 7]). Additionally, Tibetan sheep in the high-altitude arid deserts exhibit stronger adaptive selection for energy homeostasis and water utilization; meanwhile, the HIF-1 [Hypoxia Inducible Factor 1] signaling pathway helps counteract oxidative stress induced by extreme water scarcity in the plateau environment. Our study supports the hypothesis that Tibetan sheep originated in northern China and identifies distinct adaptive features in the Tibetan sheep genome corresponding to their habitats. - Source: PubMed
Publication date: 2026/01/20
Zhang WentaoYuan ChaoGuo TingtingChen BowenWang FanLiu JianbinLu Zengkui - American Indians and Hispanics/Latinos have a high burden of chronic kidney disease (CKD) and they may share disease associated genetic variants. This study aims to identify loci for CKD and albuminuria that are shared between these populations. - Source: PubMed
Reynolds Kaylia MPasteris JeremyBest Lyle GCai JiawenKramer Holly JLash James PCole ShelleyMorris Andrew PFranceschini Nora - Spatially coordinated extracellular signal-regulated kinase (ERK) signaling events (SPREADs) transmit radially from a central point to adjacent cells via secreted ligands for EGFR (epidermal growth factor receptor) and other receptors. SPREADs maintain homeostasis in nonpulmonary epithelia, but it is unknown whether they play a role in the airway epithelium or are dysregulated in inflammatory disease. To address these questions, we measured SPREAD activity with live-cell ERK biosensors in human bronchial epithelial cell lines (HBE1 and 16HBE) and primary human bronchial epithelial cells, in both submerged and biphasic air-liquid interface culture conditions (i.e., differentiated cells). Airway epithelial cells were exposed to proinflammatory cytokines relevant to asthma and chronic obstructive pulmonary disease. Type 1 proinflammatory cytokines significantly increased the frequency of SPREADs, which coincided with epithelial barrier breakdown in differentiated primary human bronchial epithelial cells. Furthermore, SPREADs correlated with IL-6 peptide secretion and the appearance of localized clusters of phospho-STAT3 immunofluorescence. To probe the mechanism of SPREADs, cells were cotreated with pharmacological treatments (gefitinib, tocilizumab, hydrocortisone) or metabolic modulators (insulin, 2-deoxyglucose). Hydrocortisone, inhibitors of receptor signaling, and suppression of metabolic function decreased SPREAD occurrence, implying that proinflammatory cytokines and glucose metabolism modulate SPREADs in human airway epithelial cells via secreted EGFR and IL6R ligands. We conclude that spatiotemporal ERK signaling plays a role in barrier homeostasis and dysfunction during inflammation of the airway epithelium. This novel signaling mechanism could be exploited clinically to supplement corticosteroid treatment for asthma and chronic obstructive pulmonary disease. - Source: PubMed
DeCuzzi Nicholaus LOberbauer DanielChmiel Kenneth JPargett MichaelFerguson Justa MMurphy DevanHardy MarionRam AbhineetZeki Amir AAlbeck John G - Sheep were domesticated in the Fertile Crescent and then spread globally, where they have been encountering various environmental conditions. The Tibetan sheep has adapted to high altitudes on the Qinghai-Tibet Plateau over the past 3000 years. To explore genomic variants associated with high-altitude adaptation in Tibetan sheep, we analyzed Illumina short-reads of 994 whole genomes representing ∼ 60 sheep breeds/populations at varied altitudes, PacBio High fidelity (HiFi) reads of 13 breeds, and 96 transcriptomes from 12 sheep organs. Association testing between the inhabited altitudes and 34,298,967 variants was conducted to investigate the genetic architecture of altitude adaptation. Highly accurate HiFi reads were used to complement the current ovine reference assembly at the most significantly associated β-globin locus and to validate the presence of two haplotypes A and B among 13 sheep breeds. The haplotype A carried two homologous gene clusters: (1) HBE1, HBE2, HBB-like, and HBBC, and (2) HBE1-like, HBE2-like, HBB-like, and HBB; while the haplotype B lacked the first cluster. The high-altitude sheep showed highly frequent or nearly fixed haplotype A, while the low-altitude sheep dominated by haplotype B. We further demonstrated that sheep with haplotype A had an increased hemoglobin-O2 affinity compared with those carrying haplotype B. Another highly associated genomic region contained the EGLN1 gene which showed varied expression between high-altitude and low-altitude sheep. Our results provide evidence that the rapid adaptive evolution of advantageous alleles play an important role in facilitating the environmental adaptation of Tibetan sheep. - Source: PubMed
Li ChaoChen BingchunLangda SuoPu PengZhu XiaojiaZhou ShiweiKalds PeterZhang KeBhati MeenuLeonard AlexanderHuang ShuhongLi RanCuoji AwangWang XiranZhu HaolinWu YujiangCuomu RenqinGui BaLi MingWang YutaoLi YanFang WenwenJia TingPu TianchunPan XiangyuCai YudongHe ChongWang LimingJiang YuHan Jian-LinChen YulinZhou PingPausch HubertWang Xiaolong