Ask about this productRelated genes to: HAS3 antibody
- Gene:
- HAS3 NIH gene
- Name:
- hyaluronan synthase 3
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 16q22.1
- Locus Type:
- gene with protein product
- Date approved:
- 1996-10-18
- Date modifiied:
- 2015-09-11
Related products to: HAS3 antibody
Related articles to: HAS3 antibody
- Previous studies suggest that thyroid cancers in the isthmus are associated with more aggressive behavior and unfavorable patient outcomes compared to lobar tumors. This study aimed to characterize the molecular features of isthmus thyroid cancer. - Source: PubMed
Kuo Chi-YuCheng Sheena Yi-HsinHsu Yi-ChiungCheng Shih-Ping - Neuroinflammation and angiogenesis are central to post-stroke repair. However, the cellular and molecular mechanisms regulating these events remain incompletely understood. The nuclear factor of activated T cells-1 (NFAT1) is implicated in inflammation and vascular remodeling, yet its role in ischemic stroke is unclear. - Source: PubMed
Publication date: 2026/03/18
Zhang YaochuanCao XuSong YifuHan XiaodiTian GuofengTao DongxiaHou AnaHan Sheng - Gut ecosystem is maintained by immune regulation through intestinal microbiota that leads to inflammatory diseases such as Gastric Cancer. Hyaluronic acid is derived from gut microorganism Streptococcus pyogenes which directly controls the up and down regulation of potential gene sets that helps to promote or inhibit gastric cancer. - Source: PubMed
Publication date: 2026/02/06
Samanta DebaleenaBhattacharya Malavika - The hyaluronic acid synthase (HAS) family participates in key physiological processes such as follicular development, oocyte maturation, ovulation, and embryo implantation by regulating the synthesis of hyaluronic acid, and plays an important role in the female reproductive system. In recent years, studies have found that the HAS family exerts important regulatory effects in female infertility-related diseases. HAS2 plays a critical role in cumulus expansion and oocyte maturation, and abnormal expression of HAS2 may lead to impaired cumulus expansion and ovulatory disorders. HAS1 and HAS3 are associated with ovarian dysfunction and decreased endometrial receptivity. In addition, abnormal expression of the HAS family is closely related to infertility-related diseases such as polycystic ovary syndrome, endometriosis, and premature ovarian insufficiency. Systematic elucidation of the roles of the HAS family will not only help to deepen the understanding of the pathological mechanisms of female infertility-related diseases, but is also expected to provide key theoretical evidence and precise interventional targets for the development of novel diagnostic biomarkers, optimization of ovulation induction protocols, and improvement of embryo implantation success rates, ultimately promoting the individualized diagnosis and treatment of female infertility. - Source: PubMed
Liu LinLiu YidanWang TingLi QiuyaoZhang XinyiLiu Qingyu - Among the microorganisms present in the microbiome of flowers, extracellular vesicles (EVs) derived from were isolated to investigate their modulatory effects on moisturizing and barrier-related molecular markers. To identify the function of major proteins in DB-21-derived extracellular vesicles (LEVs), Gene Ontology (GO) analysis was performed, revealing ATP binding, ribosomal structural proteins, and metal ion binding as predominant molecular-function categories. These proteomic characteristics provide a molecular context that supports the interpretation of the moisturizing and barrier-related responses observed in this study. To further verify new findings, we performed functional evaluations using in vitro and 3D skin models. LEVs increased the mRNA expression level of HAS3, which encodes hyaluronic acid synthase. In addition, the expression levels of filaggrin and involucrin, key proteins involved in skin barrier formation, increased, and these markers were determined a concentration-dependent increase in a 3D artificial skin model. Also, we confirmed that the expression levels of filaggrin and involucrin, which were reduced by UVB damage, were restored when LEVs were applied. In conclusion, LEVs are effective in enhancing various molecular markers related to the skin barrier function, and these results reveal that they hold promise as next-generation microbiome-based functional ingredients. - Source: PubMed
Publication date: 2025/12/08
Baek JunseokCho SeonggukLee GibokKi HosamKim Su YoungChoi Gyu-MinKim Jae HongKim Ji-WoongPark Chang-MinKim Seung-YoungChoi Byeong-MinChoi Yang Gyu