Ask about this productRelated genes to: GYPA antibody
- Gene:
- GYPA NIH gene
- Name:
- glycophorin A (MNS blood group)
- Previous symbol:
- MNS
- Synonyms:
- GPA, MN, CD235a
- Chromosome:
- 4q31.21
- Locus Type:
- gene with protein product
- Date approved:
- 2001-06-22
- Date modifiied:
- 2019-04-23
Related products to: GYPA antibody
Related articles to: GYPA antibody
- Red blood cell (RBC) transfusions are essential for treating various medical conditions, but global demand is difficult to meet due to a dwindling donor pool and compatibility issues. Pluripotent stem cells (PSCs) offer a promising alternative of blood dependent on volunteer donors for RBC production, and dogs serve as an excellent model for translational research due to their physiological and genetic similarities to humans. - Source: PubMed
Kimura KazutoTsukamoto MasayaShishida KoheiSugisaki HirokoKatahira JunTanaka MiyuuKuwamura MitsuruKol AmirOkada MikaIijima MinoruNakanishi MahitoSugiura KikuyaHatoya Shingo - The analysis of body fluid stains found at criminal scenes requires not only DNA profiles but also identification of the composition of these stains, particularly in mixed stains. Prior studies have demonstrated that forensic body fluids can be differentiated by their mRNA biomarkers.In this study, we screened a panel including 14 cSNPs located on four peripheral blood mRNA biomarkers (CD3G, ANK1, SPTB, and GYPA) and developed a multiplex assay for forensic blood identification using the SNaPshot method. Particularly, a one-step multiplex reverse transcription PCR (RT-PCR) strategy was used to generate cDNA amplicons from the corresponding mRNA by reverse transcription. The sensitivity, specificity, and capability of the multiplex SNaPshot assay for blood identification were systematically assessed. These results showed that the panel of 14 cSNPs successfully realized peripheral blood identification, including single-source body fluid as well as mixed samples. However, several peripheral blood cSNP markers were detected at low expression levels in menstrual blood and vaginal secretions. The detection sensitivity of the multiplex assay reached 1 ng total RNA input. Furthermore, 14 cSNP loci were genotyped across 19 peripheral blood samples, yielding 100% concordance between DNA- and RNA-derived profiles. Using allele frequencies of 14 cSNP loci in 100 unrelated Han individuals from northern China, the cumulative discrimination power of the 14 cSNPs was calculated to be 0.98303. - Source: PubMed
Publication date: 2026/07/11
Zhao YixiaSun YutingWei SiyiLiu QinglinJi AnquanLi CaixiaZhu Bofeng - Glucocorticoids(GCs) are widely used to treat erythropoietin-resistant anemias, yet the precise mechanisms underlying their erythropoiesis-promoting effects remain incompletely understood. - Source: PubMed
Publication date: 2026/06/27
Li MengjiaWang YaomeiHuang HongSun HaoGao MengyaSun MingxiaLi XudongLiu ZexingLiu DonghaoYan MeimeiHuang ZhenghuaZhang ZhenHu YuhanWang BozhengZhou YiweiLi SiyueAn YuLiu MiaoLiu YupengGao FengcaiGe FangfangFan WenjuanWang HaoLi XingWang FangFu GuomeiZuo ShiyuZhang BingleiMiao JinxinWang ChongSong YongpingAn XiuliCao WeijieXu LinpingLi WeiBian Zhilei - Complete, haplotype-resolved genome assemblies have provided unprecedented insight into the evolution of structurally complex, rapidly evolving regions of human genomes; however, population-scale pangenome resources of our closest relatives, chimpanzees and bonobos (genus, Pan), are necessary to ascertain the origins and evolutionary context of these loci. Here, we sequence and assemble 58 haplotypes from four distinct Pan clades to high contiguity (median contig NG50=54 Mb), including eight near-T2T genomes. These genomes reveal previously intractable genetic variation increasing estimates of genome-wide genetic diversity 6-37% across populations compared to short-read estimates. We identify recurrent structural polymorphisms across species impacting genes associated with immune response and host-pathogen interaction and find that structural variants (SVs) are 170- to 260-fold more likely than single nucleotide variants (SNVs) to exhibit high-impact effects across species. Contrasting SV patterns across primates we find that transposable element mutation rates differ by as much as threefold between species. We show that human disease-associated short tandem repeat (TR) loci have uniquely expanded in humans sensitizing our species to these TR-expansion disorders. Physically phased haplotypes enable reconstruction of genome-wide genealogical histories, uncovering ancient, functional genetic variation maintained by balancing selection, as well as signatures of recent adaptation in chimpanzee subspecies. Several malaria-associated loci exhibit ancient structural polymorphism, including the African great ape-specific glycophorin (GYP) gene expansion. We characterize the sequence, structure, and composition of diverse glycophorin haplotypes in humans and chimpanzees. We identify independent malaria-protective GYPA-B fusion events in humans and novel chimpanzee glycophorin genes resulting from both ancient and recent fusion events demonstrating parallel adaptations to pathogen resistance across hominins. Together, our resource highlights the critical importance of nonhuman primate population-scale pangenomics for understanding the evolution of complex genome structures and the biodiversity of our endangered closest living relatives. - Source: PubMed
Publication date: 2026/06/08
Rocha JoanaLou Runyang NicolasDe Lima Adam CarolinaHebbar PrajnaFerguson ScottBolognini DavideKillilea AlisonHoekzema KendraGuarracino AndreaDeng YunSoranzo NicolePaten BenedictGarrison ErikPollen AlexEichler EvanRohlfs RoriMitchell MatthewSudmant Peter H - The antigens in the MNS blood group system, presented on glycophorin (GP), are regulated by the GYPA, GYPB, and GYPE genes. Some hybrid GP can express Mi antigen, the most common being GP.Mur. Of potential clinical significance in transfusion practice, GYP*Mur homozygotes can produce anti-JENU because they lack expression of the high-frequency JENU antigen. Although serological typing using anti-Mi is very likely to identify GP.Mur, this method cannot reliably distinguish the underlying GP or confirm the zygosity of GP.Mur, which is relevant for transfusion safety. We, therefore, developed and validated a polymerase chain reaction with high-resolution melting (PCR-HRM) assay for distinguishing homozygous GYP*Mur from heterozygous GYP*Mur/GYPB and homozygous GYPB genotypes. - Source: PubMed
Publication date: 2026/06/12
Khantisitthiporn OnruedeeNathalang OytipIntharanut KamphonChoychimplee Tanaporn