Ask about this productRelated genes to: GULP1 antibody
- Gene:
- GULP1 NIH gene
- Name:
- GULP PTB domain containing engulfment adaptor 1
- Previous symbol:
- -
- Synonyms:
- CED6, CED-6, GULP
- Chromosome:
- 2q32.1-q32.2
- Locus Type:
- gene with protein product
- Date approved:
- 2004-01-13
- Date modifiied:
- 2018-08-15
Related products to: GULP1 antibody
Related articles to: GULP1 antibody
- Biological mechanisms underlying heterogeneous antipsychotic response in schizophrenia remain incompletely understood. In this exploratory cross-sectional study, we applied deep data-independent acquisition LC-MS/MS plasma proteomics to 56 adults initially enrolled (14 per group), including healthy controls and patients meeting TRRIP criteria for treatment-sensitive (TSS), treatment-resistant (TRS), and ultra-treatment-resistant schizophrenia (UTRS). Following proteomic quality control and exclusion of outliers, 52 individuals comprised the final analytical cohort. Proteomic data were analyzed using a layered strategy integrating covariate adjustment, variance partitioning, mediation analysis, monotonicity filtering, LASSO stability assessment, and redundancy reduction. More than 1400 plasma proteins were quantified; 450 differed across groups before adjustment, and 310 reviewed proteins remained significant after covariate modeling. A sensitivity-associated profile distinguishing TSS from controls (CRP, CCDC62, FBXW7, GULP1, CALD1, COPS6) was consistent with lower inflammatory tone and relative preservation of proteostatic and cytoskeletal regulation. In contrast, a resistance-associated profile separating TRS/UTRS from TSS (SHROOM1, MYH7, ABR, EZR, SERPINF2) converged on cytoskeletal organization, actin-membrane dynamics, and extracellular regulatory processes. Directionally concordant but quantitatively amplified changes were observed in UTRS relative to TRS, although multivariate separation between resistant subgroups was limited after full covariate adjustment. Several proteins enriched in resistant groups corresponded to intracellular or nuclear factors rarely detected in plasma and require cautious interpretation. Overall, these findings are compatible with a progression-like molecular pattern in which treatment sensitivity and resistance may reflect shifts in cellular adaptability and structural regulation. Replication in larger and longitudinal cohorts is required. - Source: PubMed
Publication date: 2026/04/27
de Oliveira Caio AndradeSoares Michelle Verde Ramode Pinho Carolina Saraiva NunesPinto Joel PorfírioFrota Annyta FernandesMoreira Ana Cristina de OliveiraSilva Maria Francilene SouzaBatista Tiago de OliveiraHallak Jaime Eduardo CecilioSheheryar SheheryarMoura Arlindo De Alencar Araripe NoronhaSanders Lia Lira OGallo Margareth Borges Coutinhode Sousa Felipe DomingosMacedo Danielle S - - Source: PubMed
Publication date: 2026/04/21
Jiang Meng-YuanZhang Xiao-HuaZhang Huan-LeHou YueQi Mei-YingZuo Yi-XuanSun ChuangDai Xin-ChunZhang Ning-NingChen Tian-QiZhang YanMan Wan-RongLi Cong-YeLin JieGe WenYang Li-YuQin XingSun Dong-Dong - Major depressive disorder (MDD) is a chronic mental illness rapidly approaching the status of a significant global burden of disease. This study is aimed at investigating novel biomarkers in MDD and performing a comprehensive analysis of immune infiltration through an integrated bioinformatics approach. - Source: PubMed
Kangsheng LongXiaohui YangXin PeiYong YeHongliang LiYihui Deng - Inflammatory dysregulation and tissue homeostatic imbalance are the fundamental pathological mechanisms underlying the progression of various types of chronic disease, and identifying key regulatory molecules is important for achieving effective anti‑inflammatory therapeutic goals. Stabilin‑1, an immunoregulatory scavenger receptor, regulates inflammation and tissue homeostasis in multiple ways. In the field of innate immunity, Stabilin‑1 acts as a monocyte‑recruiting factor through the interaction of fibronectin with its extracellular fasciclin domain and mediates the polarization of macrophages to M2‑type cells. In addition, its extracellular epidermal growth factor‑like domain can recognize and interact with phosphatidylserine on the surface of apoptotic cells, and bind to its corresponding Gulp1 adapter molecules, activating downstream signalling pathways and making the clearance of these apoptotic cells possible. It can also specifically recognize and take up oxidative stress products, such as oxidized low‑density lipoprotein and lipopolysaccharide, inhibiting the activation of any proinflammatory signal transduction pathway. In adaptive immune regulation, Stabilin‑1 can inhibit the T‑helper cell (Th)1 type immune response and regulate the Th2 type immune response. The inflammatory microenvironment induces the synthesis of Stabilin‑1 and its surface localization on blood and lymphatic endothelial cells, mediating the transendothelial migration of immune cells such as regulatory T cells and B cells to regulate the intensity of immune responses. Stabilin‑1 has regulatory functions in different diseases, such as atherosclerosis, chronic liver disease, viral myocarditis, infection, sepsis and tumours. The present review discusses the role of Stabilin‑1 as an immunomodulatory scavenger receptor in inflammatory microenvironments and tissue homeostasis, providing novel theoretical support and potential therapeutic targets for the targeted treatment of inflammation‑related diseases. - Source: PubMed
Publication date: 2026/03/27
Xiang Xiao-LeiYe Xin-TongWu Yu-TongChen ChenYu Chu-YingQian Su-TingCai Dan-Li - China has abundant resources of local goose breeds with significant differences in growth rates among breeds. These differences provide natural genetic materials for exploring key functional genes and molecular markers of growth traits. The genetic loci related to growth rate are important economic traits that affect slaughter weight and feeding costs. In view of this, we used genome-wide association analysis (GWAS) method to determine the genes related to growth rate. - Source: PubMed
Publication date: 2026/02/10
Wang HongningZhao HongchangZhu ShanyuanJian WangGong Daoqing