CD43
- Known as:
- CD43
- Catalog number:
- 11-220-C100
- Product Quantity:
- 0.1 mg
- Category:
- -
- Supplier:
- Exbio
- Gene target:
- CD43
Related genes to: CD43
- Gene:
- SPN NIH gene
- Name:
- sialophorin
- Previous symbol:
- -
- Synonyms:
- LSN, CD43, GPL115
- Chromosome:
- 16p11.2
- Locus Type:
- gene with protein product
- Date approved:
- 1988-08-31
- Date modifiied:
- 2016-07-19
Related products to: CD43
Related articles to: CD43
- Parkinson's disease (PD) is known to alter the intrinsic properties of striatal cholinergic interneurons (ChIs). However, how PD shapes ChI control of intrastriatal GABAergic circuits regulating principal spiny projection neurons (SPNs) is unknown. To fill this gap, striatal circuits in healthy and parkinsonian mice were interrogated. In brain slices from healthy mice, optogenetic stimulation of ChIs evoked GABA receptor currents in both indirect and direct pathway SPNs that were attributable to nicotinic acetylcholine receptor (nAChR)-mediated activation of GABAergic interneurons (GIs). Simulations suggested that this circuit exerts a state-dependent control of SPN dendritic integration that was modulated by concomitant muscarinic receptor signaling. Surprisingly, in mouse models of prodromal and parkinsonian states, the ability of ChIs to engage this intrastriatal circuitry was disrupted because interneurons down-regulated nicotinic AChRs. Taken together, these studies suggest that impaired ChI control of GABAergic interneurons contributes to behavioral deficits in both prodromal and clinical PD states. - Source: PubMed
Publication date: 2026/06/22
Belal MPerez-Rosello TGuven E BKocaturk SXie ZIlijic ETkatch TLi JDauer WAssous MTepper J MClarke V R JSurmeier D J - Myofascial pain syndrome (MPS) is a common cause of chronic musculoskeletal pain. Long fibular syndrome is a symptom of lower-limb MPS. Research has associated MPS with motor end plates in the innervation zone. This study aimed to identify the anatomical entry points of the superficial peroneal nerve (SPN) in the peroneal longus (PL) and peroneal brevis (PB) muscles through dissection. - Source: PubMed
Publication date: 2026/06/29
Delantonia Nazareth CristinaPark Lucas YongsooHojaij FlávioAndrade MauroJacomo Alfredo LuizJacomo Flavia Emi Akamatsu - EEG can be used to measure the brain response to visual regularity. Reflectional symmetry generates an event-related potential (ERP) named the sustained posterior negativity (SPN). The SPN for reflectional symmetry is generated automatically, whatever the participant's task. This may be because reflectional symmetry has a fundamental role in perceptual organization and guiding adaptive behaviour. In contrast, other types of regularity, such as glass patterns, do not have this ecological significance. We thus predicted that the glass pattern SPN would be more susceptible to experimental variations of task than the reflection SPN. To test this prediction, we ran three experiments on three different groups of 52 participants. All participants saw the same random, reflection and glass dot dipole stimuli. The stimuli were either black or white. In the Regularity Task, participants discriminated whether the patterns were random or regular (where regular means reflection or glass). In the Luminance task, participants discriminated whether the patterns were black or white. In the Cross task, participants discriminated whether the vertical or horizontal arm of the central fixation cross was longer. As predicted, both the reflection and glass SPN were largest in the Regularity task, reduced in the Luminance task and reduced again in the Cross task. Contrary to predictions, glass pattern SPNs were less affected by task than reflection SPNs. This unexpected result suggests that glass patterns may even be processed more automatically than reflection, although this would require replication before it is treated as secure knowledge. - Source: PubMed
Buckley NedMakin Alexis D J - Animal models reveal that striatal projection neurons (SPNs) fluctuate between discrete electrophysiological states with distinct levels of cortical interaction. These dynamics and their behavioral relevance remain uncharacterized in humans. Leveraging neurobiologically informed modeling of over 3 billion voxel-frame-wise striatal coactivation profiles with cortex in functional magnetic resonance imaging (fMRI), we identified population-level striatal states in humans resembling canonical SPN states that reorganized systematically with task demands, arousal and behavior. A background of low- and moderate-coactivation "down-like" and "up-like" striatal rest states with high transition reciprocity modulated task reaction times and reward reactivity. Meanwhile, sparse, disproportionately high-magnitude "bursts" of striatal coactivation with cortex, which emerged preferentially from the up-like rest state and whose cortical input composition varied with task context, tracked task engagement and arousal level. Findings bring a critical feature of corticostriatal neurobiology into systems-level view in humans and reveal a subthreshold state architecture whose balance encodes behaviorally relevant information. - Source: PubMed
Publication date: 2026/06/18
Korponay ColeStein Elliot ARoss Thomas JJanes Amy C - Arsenic is a widespread environmental contaminant with well-documented immunotoxic and developmental effects. However, its impact on the earliest stages of human hematopoietic development remains poorly understood. Using human induced pluripotent stem cells (iPSCs), we examined how sodium arsenite (NaAsO₂) affects the formation of hematopoietic stem and progenitor cells (HSPCs), which are essential for lifelong blood production. Exposure to NaAsO₂ during directed differentiation of iPSCs to HSPCs showed that the formation of pre-HSPCs (CD34⁺CD43⁺CD45⁻) were more sensitive, with significant reduction to 45% of the untreated control at 1 µM. In contrast, the formation of mature-HSPCs (CD34⁺CD43⁺CD45⁺) displayed a biphasic response, with a modest elevation to 113% of control at 0.1 µM, followed by significant reduction to 63% of control at 1 µM. Time‑addition experiments revealed that suppression occurred when NaAsO₂ was present during hematopoietic differentiation or across both mesodermal and hematopoietic phases. In contrast, transient exposure during mesoderm alone did not alter HSPC numbers. Functionally, HSPCs derived from NaAsO₂-treated iPSCs showed reduced blood-forming capacity, with marked decreases in erythroid, granulocyte-macrophage, and multipotent progenitors. Gene expression analysis showed downregulation of critical regulators during embryonic hematopoiesis, including mesodermal regulators (MIXL1, TBXT), hematopoietic markers (SPN, PTPRC), and lineage-specific transcription factors (SPI1). Collectively, these findings demonstrate that arsenic perturbs the formation of HSPCs in a stage‑dependent manner, broadening its toxicological relevance from erythropoiesis to the earliest steps of human blood formation. - Source: PubMed
Publication date: 2026/06/27
Ngaotepprutaram ThitiratNavasumrit PanidaRuchirawat Mathuros