Ask about this productRelated genes to: GEMIN4 antibody
- Gene:
- GEMIN4 NIH gene
- Name:
- gem nuclear organelle associated protein 4
- Previous symbol:
- -
- Synonyms:
- HHRF-1, DKFZP434B131, p97, DKFZP434D174, HC56, HCAP1
- Chromosome:
- 17p13.3
- Locus Type:
- gene with protein product
- Date approved:
- 2001-08-07
- Date modifiied:
- 2015-11-06
Related products to: GEMIN4 antibody
Related articles to: GEMIN4 antibody
- To investigate genetic variants associated with the dysregulation of lens epithelial cell (LEC) homeostasis in patients with dead bag syndrome (DBS). - Source: PubMed
Sankaranarayanan RajkumarVasavada Abhay RVasavada Shail AVasavada Vaishali - This study was designed to identify genes for further study as modifiers of the severity of cardiomyopathy in DMD-related Duchenne Muscular Dystrophy (DMD). - Source: PubMed
Publication date: 2026/01/07
Geddes Gabrielle CWare Stephanie MSchwantes-An Tae-HwiAbreu Marco AParent John JEarl Conner CSoslow Jonathan HMarkham Larry W - Triple-negative breast cancer (TNBC) is the most malignant breast cancer subtype. The 5-year overall survival rate of TNBC patients is 77%, but once cancer metastasis occurs, this rate drops to 12%. To date, the discovery of biomarkers associated with TNBC metastasis remains a major challenge. In this study, we identified a novel translated product, XLH-36 micropeptide, encoded by lncRNA (long non-coding RNA) C5orf66-AS1, which acts as an "oncogenic driver" in TNBC. Through conservation analyses across 101 species, we found that XLH-36 is highly conserved in humans and primates. Analysis of RNA-seq data from 1295 breast cancer patients, including 165 TNBC patients from different cohorts, revealed significantly elevated XLH-36 expression levels in breast cancer and TNBC. Specifically, TNBC patients with low C5orf66-AS1 (encoding XLH-36) expression demonstrated a 20% higher overall survival rate compared to those with high C5orf66-AS1 expression over a 50-month follow-up. XLH-36 knockout inhibited the growth and metastasis of TNBC xenografts in mice. Furthermore, we found that XLH-36 directly binds Gemin4, causing it to remain in the cytoplasm and preventing it from carrying out its role in promoting S100A4 mRNA splicing in the nucleus. This leads to a compensatory increase in ICAM1 levels, ultimately resulting in the promotion of epithelial-to-mesenchymal transition (EMT) in TNBC cells and an increase in tumor metastasis. In summary, our findings highlight the crucial role of XLH-36 in TNBC metastasis, which could be exploited in the development of therapeutic and diagnostic strategies for TNBC patients. - Source: PubMed
Publication date: 2025/11/29
Li MengweiXie WenweiHu KexinLi TiantianLi XinShun LiXu XiaoweiChen JunhuiXu Hanmei - - Source: PubMed
Koizumi HarukaMuro YoshinaoKamiya SatoshiAkashi NorikaYamashita YutaOgawa-Momohara MarikoTakeichi TakuyaAkiyama Masashi - We aimed to elucidate the potential correlation between single-nucleotide polymorphisms (SNPs) in miRNA machinery genes and colorectal cancer (CRC) risk in an Iranian cohort. - Source: PubMed
Mobaraki MarziehAghdaei Hamid AsadzadehAngaji Seyed AbdolhamidNazemalhosseini-Mojarad EhsanArbabian Sedigheh