Ask about this productRelated genes to: GCHFR antibody
- Gene:
- GCHFR NIH gene
- Name:
- GTP cyclohydrolase I feedback regulator
- Previous symbol:
- -
- Synonyms:
- GFRP, HsT16933
- Chromosome:
- 15q15.1
- Locus Type:
- gene with protein product
- Date approved:
- 1996-12-18
- Date modifiied:
- 2016-10-05
Related products to: GCHFR antibody
Related articles to: GCHFR antibody
- Gout is a systemic metabolic disease with rising prevalence and complex etiology, yet its molecular mechanisms remain incompletely defined. Multi-omics Mendelian randomization (MR) enables causal prioritization of genes implicated in gout. Because the gut microbiota (GM) can modulate urate metabolism and inflammation, integrating microbiome analyses may help nominate potential therapeutic candidates. This study aimed to nominate candidate targets for gout by integrating multi-omics MR, clinical validation, GM analysis, and in-silico druggability assessment. - Source: PubMed
Publication date: 2025/12/20
Zhao YuGao MinWang FanPang LeiLi HaiboLin XiaoshengChen Lihua - Idiopathic pulmonary fibrosis (IPF) is a kind of interstitial lung disease with a poor prognosis. Even though genome-wide association studies (GWAS) have identified numerous loci linked to IPF risk, the underlying causal genes and biological processes are still mostly unknown. - Source: PubMed
Publication date: 2025/08/26
Shi JiaxinZhang Linyou - Hundreds of genetic associations for asthma have been identified, yet translating these findings into mechanistic insights remains challenging. We leveraged plasma proteomics from the UK Biobank Pharma Proteomics Project (UKB-PPP) to identify biomarkers and effectors of asthma risk or heterogeneity using genetic causal inference approaches. We identified 609 proteins associated with asthma status (269 proteins after controlling for body mass index [BMI] and smoking). Analysis of genetically predicted protein levels identified 70 proteins with putative causal roles in asthma risk, including known drug targets and proteins without prior genetic evidence in asthma (e.g., GCHFR, TDRKH, and CLEC7A). The genetic architecture of causally associated proteins provided evidence for a Toll-like receptor (TLR)1-interleukin (IL)-27 asthma axis. Lastly, we identified evidence of causal relationships between proteins and heterogeneous aspects of asthma biology, including between TSPAN8 and neutrophil counts. These findings illustrate that integrating biobank-scale genetics and plasma proteomics can provide a framework to identify therapeutic targets and mechanisms underlying disease risk and heterogeneity. - Source: PubMed
Publication date: 2025/04/04
Donoghue Lauren JBenner ChristianChang DianaIrudayanathan Flaviyan JeromePendergrass Rion KYaspan Brian LMahajan AnubhaMcCarthy Mark I - An understanding of the molecular mechanism whereby an environmental chemical causes a disease is important for the purposes of future applications. In this study, a multiomics workflow was designed to combine several publicly available datasets in order to identify CpG sites and genes that mediate the impact of exposure to environmental chemicals on cardiometabolic traits. Organophosphate and prenatal lead exposure were previously reported to change methylation level at the cg23627948 site. The outcome of the analyses conducted in this study revealed that, as the cg23627948 site becomes methylated, the expression of the gene decreases, which leads to a higher body fat percentage. Prenatal perfluorooctane sulfonate exposure was reported to increase the methylation level at the cg21153102 site. Findings of this study revealed that higher methylation at this site contributes to higher diastolic blood pressure by changing the expression of and genes. Moreover, mediates the impact of B12 supplementation → cg05280698 hypermethylation on higher kidney function, while mediates the impact of air pollution → cg03186999 hypomethylation on higher systolic blood pressure. This study investigates CpG sites and genes that mediate the impact of environmental chemicals on cardiometabolic traits. Furthermore, the multiomics approach described in this study provides a convenient workflow with which to investigate the impact of an environmental factor on the body's biomarkers, and, consequently, on health conditions, using publicly available data. - Source: PubMed
Publication date: 2024/07/29
Nikpay Majid - A substantial proportion of common variable immunodeficiency (CVID) patients has duodenal inflammation of largely unknown etiology. However, because of its histologic similarities with celiac disease, gluten sensitivity has been proposed as a potential mechanism. - Source: PubMed
Publication date: 2022/10/08
Kaarbø MariYang MingyiHov Johannes RHolm Kristiande Sousa Mirta Mittelstedt LealMacpherson Magnhild EReims Henrik MKran Anne-Marte BakkenHalvorsen BenteKarlsen Tom HAukrust PålLundin Knut E AFevang BørreBjørås MagnarJørgensen Silje Fjellgård