Ask about this productRelated genes to: GADL1 antibody
- Gene:
- GADL1 NIH gene
- Name:
- glutamate decarboxylase like 1
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 3p24.1-p23
- Locus Type:
- gene with protein product
- Date approved:
- 2004-07-28
- Date modifiied:
- 2018-02-13
Related products to: GADL1 antibody
Related articles to: GADL1 antibody
- Glutamate decarboxylase-like 1 (GADL1) decarboxylates aspartic acid to β-alanine in several mammalian tissues, particularly in the brain and skeletal muscle. β-alanine is a precursor to the antioxidant and osmoregulatory dipeptide carnosine (β-alanyl-l-histidine), as well as pantothenic acid and coenzyme A. Deletion of GADL1 reduces carnosine and anserine levels in multiple tissues, but the consequences for brain metabolism remain unclear. This study aimed to explore sex-specific metabolic and cellular effects of GADL1 and β-alanine depletion in different areas of the brain. - Source: PubMed
Publication date: 2026/05/23
Homaei Selina CannonMahootchi ElahehSrivastava AashishGomladu Mahima SanjayKrokengen Oda CasparaBaumann AnneHaavik Jan - The flavor of chicken meat is formed by a series of complex chemical reactions, and the flavor precursors are affected by regulatory genes. In order to study the differences of muscle flavor precursors between Tengchong Snow chickens and AA broilers, integrated metabolomics and transcriptomics analyses were used to investigate muscle metabolite profiles and the key genes involved in the metabolism of muscle flavor compounds. The results showed that 42 significantly differentially metabolites were detected, and (5-L-Glutamyl)-L-glutamate, gamma-Glutamylalanine, S-Adenosylhomocysteine, Homo-L-arginine and GMP were important flavor metabolites. The key candidate genes with high correlation with flavor precursor metabolites were identified through correlation analysis as , , , , , and . In addition, the gene-metabolite interaction network for flavor formation in chicken breast muscle was constructed. This study could provide some basic data for the formation mechanism of local chicken excellent meat quality, and provide reference for the development and utilization of local chicken breeds and the selection and breeding of high-quality broilers. - Source: PubMed
Publication date: 2026/03/10
Yang MinZhang RuifangZhao JingyingJian ZonghuiWu HaoZi XiannianWang KunXu ZhiqiangGe ChangrongJia JunjingLiu LixianDou Tengfei - Sudden Unexpected Death in Epilepsy (SUDEP) refers to the unexplained, sudden death of individuals with epilepsy, and its incidence is closely linked to the severity and duration of seizures. This study aimed to identify plasma biomarkers associated with SUDEP through a combined proteomics and metabolomics approach. - Source: PubMed
Publication date: 2026/03/09
Zheng GaolinYang XinyanChen YinyuZhang PengNie Qianyun - Amino acid metabolic (AAM) reprogramming is a key characteristic of gastric cancer (GC) cells metabolic remodeling, which regulates cell growth, survival, immune cell activation and function to affect tumor immune escape. This study aims to systematically investigate AAM reprogramming in gastric cancer (GC) and construct prognostic model, and validate gene signatures for predictive value and clinical decision-making. This study leveraged data from TCGA and GEO to construct a prognostic model related to AAM and assess its clinical relevance in GC. We identified differentially expressed genes and conducted GO, GSEA, and GSVA enrichment analyses, along with constructing PPI networks and interaction networks of mRNA-miRNA, mRNA-TF, and mRNA-RBP. Additionally, immune infiltration analysis was performed and the relationships between eight hub-type amino acid metabolism-related genes (AAMRGs) and immune cells was investigated using scRNA-seq datasets. Lastly, we validated the elevated expression of these eight genes in GC cells through PCR. The study constructed a prognostic model for GC based on AAMRGs, identifying 16 key genes: ACLY, ADH4, COL1A1, F2, GADL1, GAMT, HBB, KYNU, MRI1, MTHFR, NR1D1, PDK4, SLC1A7, SLC25A15, SLC52A3, and SYCE2. Statistical analysis showed that 14 of these genes showed significant differential expression between tumor and normal tissues. Furthermore, the model demonstrated strong correlations with OS outcomes. Immune infiltration analysis indicated that various immune cell types were significantly associated with the expression of 8 hub genes, highlighting their potential role in the tumor microenvironment and immune response modulation. Furthermore, elevated expression of these genes in GC cells was validated through PCR, highlighting their relevance as potential biomarkers and therapeutic targets. Our AAMRGs prognostic model reveals AAMRGs as independent prognostic factors for GC, highlighting their association with prognosis and immune cell infiltration. These findings provide important insights for improving survival outcomes and advancing immunotherapy strategies in GC. - Source: PubMed
Publication date: 2026/03/05
Zhang HuanYe WeiZeng LingzhiWang LuGui Ling - Muscle traits are critical determinants of meat quality and productivity in sheep, influenced by both breed and anatomical region. Hanzhong sheep, an indigenous Chinese breed, are prized for tender, low-odor meat; yet, the molecular mechanisms underlying these traits remain poorly understood. In this study, we integrated meat quality assessment with metabolomic and transcriptomic profiling of the longissimus dorsi (HZ-B) and triceps brachii (HZ-T) muscles to elucidate biochemical and molecular bases of regional differences. The results, derived from metabolomic profiling, demonstrated that the muscle tissue of Hanzhong sheep contained abundant proteins (95 kinds) and fatty acids (150 kinds). The greater tenderness of HZ-B compared to HZ-T was associated with higher levels of dipeptides such as carnosine (FC = 1.07) and anserine (FC = 1.04), as well as upregulated expression of oxidative fiber-related genes MYH2 (FC = 2.92) and TPM1 (FC = 2.15). In contrast, HZ-T showed enrichment of flavor-associated metabolites, including acylcarnitines and glutamate, alongside higher expression of (FC = 0.35) and (FC = 0.47), linked to structural integrity and muscle contraction. Integrated analysis revealed strong associations between metabolite abundance (carnosine/anserine) and key genes (/), suggesting coordinated regulation of meat quality traits. These findings provide mechanistic insights into the metabolic and transcriptomic determinants of muscle quality in Hanzhong sheep, offering a foundation for genetic improvement and conservation strategies. - Source: PubMed
Publication date: 2025/09/23
Li ZhiZheng MiaohuaLi WeiweiLi JiayiWang LingWang ShanshanLu HongzhaoZhang Tao