Ask about this productRelated genes to: FN3KRP antibody
- Gene:
- FN3KRP NIH gene
- Name:
- fructosamine 3 kinase related protein
- Previous symbol:
- -
- Synonyms:
- FLJ12171, FN3KL
- Chromosome:
- 17q25.3
- Locus Type:
- gene with protein product
- Date approved:
- 2009-01-14
- Date modifiied:
- 2015-09-07
Related products to: FN3KRP antibody
Related articles to: FN3KRP antibody
- Arteriovenous fistula (AVF) is the preferred vascular access for hemodialysis; however, its patency is limited, particularly in patients with diabetes mellitus (DM). This study aimed to obtain exploratory data on whether changes in the venous transcriptome are present at the time of AVF creation in patients with DM and whether these changes are related to the graft prognosis. - Source: PubMed
Publication date: 2026/08/06
Shirouzu TomohiroKoga Jun-IchiroKatafuchi EisukeNagai YoichiroSuga RyotaSanada KenyaUeno HiromichiNakazono KazutoshiHasegawa EmiMiyamoto TetsuNakayama ToshiyukiKataoka Masaharu - The midnolin-proteasome pathway represents a crucial ubiquitin-independent protein degradation mechanism. However, its precise interactome, including both degradative substrates and nondegradative interactors, remains largely uncharacterized due to the limitations of conventional approaches. To address this, we developed a robust multiplexed photo-cross-linking platform for comprehensively profiling the midnolin interactome. This platform uniquely integrates two distinct chemical biology strategies: first, the genetic encoding of a photo-cross-linking unnatural amino acid into midnolin's Catch domain and second, the use of a residue-selective photo-cross-linker, enabling the covalent capture and subsequent proteomic profiling of protein-protein interactions. Using this platform, we successfully identified numerous midnolin interactors, including several newly identified degradative substrates (e.g., ETV3, JUN, PRKD1, FN3KRP) and multiple nondegradative binding interactors, significantly expanding its known interactome repertoire. Collectively, our research establishes an innovative platform for investigating the context-dependent interactome of the midnolin system. This platform offers unprecedented insights into midnolin's multifaceted roles in ubiquitin-independent degradation and diverse cellular processes. Furthermore, leveraging this platform to explore midnolin interactome across various biological contexts holds significant potential. It could accelerate the development of next-generation strategies for degrading pathogenic proteins and aid in the discovery of therapeutic targets, particularly for those undruggable targets that resist conventional ubiquitin-dependent approaches. - Source: PubMed
Publication date: 2026/03/12
Xu YaliZhao WensiFu JingjingLiu ZihaoNie Hui-JunZhang JunGuo JingliTan MinjiaChen Xiao-Hua - Age at menarche (AAM) has been associated with type 2 diabetes mellitus (T2DM). However, little is known about their shared heritability. Our data comes from the Taiwan Biobank. Genome-wide association studies (GWASs) were conducted to identify single-nucleotide polymorphisms (SNPs) related to AAM-, T2DM-, and T2DM-related phenotypes, such as body fat percentage (BFP), fasting blood glucose (FBG), and hemoglobin A1C (HbA). Further, the conditional false discovery rate (cFDR) method was applied to examine the shared genetic signals. Conditioning on AAM, Quantile-quantile plots showed an earlier departure from the diagonal line among SNPs associated with BFP and FBG, indicating pleiotropic enrichments among AAM and these traits. Further, the cFDR analysis found 39 independent pleiotropic loci that may underlie the AAM-T2DM association. Among them, rs1046896 (cFDR = 6.84 × 10), rs2206734 (cFDR = 6.48 × 10), rs58431774 (cFDR = 2.95 × 10), rs1402837 (cFDR = 1.82 × 10), and rs60808706 (cFDR = 9.49 × 10) were highlighted for their significant genetic enrichment. The protein-protein interaction analysis revealed a significantly enriched network among novel discovered genes that were mostly found to be involved in the insulin and glucagon signaling pathways. Our study highlights potential pleiotropic effects across AAM and T2DM. This may shed light on identifying the genetic causes of T2DM. - Source: PubMed
Publication date: 2024/01/11
Cheng Yuan-FangYang Cheng-YiTsai Meng-Che - Research has shown epigenetic change via alternation of the methylation profile of human skeletal muscle DNA after Cardio-Pulmonary Bypass (CPB). In this study, we investigated the change in epigenome-wide DNA methylation profiles of porcine myocardium after ischemic insult in the setting of treatment with extracellular vesicle (EV) therapy in normal . high-fat diet (HFD) pigs. - Source: PubMed
Publication date: 2023/11/03
Broadwin MarkAghagoli GhazalSabe Sharif AHarris Dwight DWallace JoselynnLawson JordanRagayendran AshokFedulov Alexey VSellke Frank W - Recurrent pregnancy loss (RPL) is typically defined as two or more consecutive pregnancy losses prior to 20 weeks of gestation. Although the causes of idiopathic RPL are not completely understood, vascular development and glucose concentration were reported to correlate with the pregnancy loss. The TGF-β signaling pathway which plays a significant role in pregnancy is activated by the interaction between high glucose and SMAD signaling and affects the vascular cells. SMAD5 and RUNX-1 are involved in the TGF-β signaling pathway and contribute to advanced glycation end products (AGEs) production and vascular development. FN3KRP, a newly described gene, is also associated with vascular diseases and suggested to relate to AGEs. Therefore, in the present study, we investigated associations between RPL risk and genetic polymorphisms of SMAD5, FN3KRP, and RUNX-1 in 388 women with RPL and 280 healthy control women of Korean ethnicity. Participants were genotyped using real-time polymerase chain reaction and restriction fragment length polymorphism assay to determine the frequency of SMAD5 rs10515478 C>G, FN3KRP rs1046875 G>A, and RUNX-1 rs15285 G>A polymorphisms. We found that women with RPL had lower likelihoods of the FN3KRP rs1046875 AA genotype (adjusted odds ratio (AOR), 0.553; p = 0.010) and recessive model (AOR, 0.631; p = 0.017). Furthermore, combination analysis showed that SMAD5 rs10515478 C>G and FN3KRP rs1046875 G>A mutant alleles were together associated with reduced RPL risk. These findings suggest that the FN3KRP rs1046875 G>A polymorphism has a significant role on the prevalence of RPL in Korean women. Considering that it is the first study indicating a significant association between FN3KRP and pregnancy disease, RPL, our results suggest the need for further investigation of the role of FN3KRP in pregnancy loss. - Source: PubMed
Publication date: 2022/06/22
Kwon Min-JungKim Ji-HyangLee Jeong-YongKo Eun-JuPark Hyeon-WooShin Ji-EunAhn Eun-HeeKim Nam-Keun