Ask about this productRelated genes to: CNBP antibody
- Gene:
- CNBP NIH gene
- Name:
- CCHC-type zinc finger nucleic acid binding protein
- Previous symbol:
- DM2, ZNF9
- Synonyms:
- RNF163, ZCCHC22, CNBP1
- Chromosome:
- 3q21.3
- Locus Type:
- gene with protein product
- Date approved:
- 1989-12-11
- Date modifiied:
- 2016-10-05
Related products to: CNBP antibody
Related articles to: CNBP antibody
- Tandem repeat expansions (TREs) cause over 60 known neurological, neuromuscular, and developmental disorders. Detecting these expansions genome-wide is challenging due to their size, sequence complexity (including interruptions), and population variation. While long-read sequencing is an emerging technology that can fully resolve many TREs, no methods have been described for genome-wide identification and prioritization of candidate pathogenic TREs with this technology. - Source: PubMed
Publication date: 2026/05/01
Gibson Sophia BDamaraju NikhitaGustafson J GusBalton Elsa VChanprasert SirisakGlass Ian AHorike-Pyne MarthaKumar Runjun DLeppig Kathleen ALundberg ChrisRanchalis JaneRosenthal Elisabeth ASolomon Andrew KStergachis Andrew BWener Mark Jarvik Gail PBlue Elizabeth EDipple Katrina MDashnow HarrietStarita Lea MMiller Danny E - The natural and organic poultry production industry is growing. This is in response to rising consumer demand for poultry products that are natural and organic. The purpose of this study was to examine the effects of dietary inclusion of cinnamon and fennel powder as natural feed additives on growth performance and carcass traits of broilers. A total of 210 day-old chicks were randomly assigned to five dietary treatments. The control group (T1) was provided with a standard diet containing no fennel seed powder (FNSP) and cinnamon bark powder (CNBP), while the other groups received a standard diet plus 0.75% FNSP (T2), standard diet plus 1.75% FNSP (T3), standard diet plus 0.75% CNBP (T4), and standard diet plus 1.75% CNBP (T5). Feed intake data were taken daily, while the body weight change was measured at a weekly interval. At the end of the experiment, three chickens from each treatment were picked and slaughtered for carcass traits measurements. The results revealed that broilers fed a diet containing 1.75% CNBP achieved significantly ( = 0.036) higher final body weight gain of 3243 ± 58.88 g, average daily weight gain of 70.88 ± 1.20 g and the best feed conversion ratio ( = 0.033) of 1.44 ± 0.03 at the end of the experiment when compared to the control group. Additionally, significantly higher dressed ( = 0.039) and eviscerated ( = 0.008) weights were found in 1.75% CNBP compared to the control. Furthermore, broilers in CNBP at 1.75% and 0.75% had significantly higher ( = 0.001) breast, thigh, and whole leg weight over the control and other treatments, except for the 1.75% FNSP group, which had significantly higher breast weight than the control. In general, incorporation of cinnamon powder in broilers' diet, particularly at a level of 1.75%, showed significant improvement in overall growth performance and carcass traits. - Source: PubMed
Publication date: 2026/04/24
Bezahegn AbebeTamir BerhanMamo Gezahegne - Myotonic dystrophy type 2 (DM2) is an autosomal dominant, multisystemic disorder caused by the expansion of CCTG repeats in the first intron of the CNBP gene. Repeat-associated non-AUG (RAN) translation of the expanded CCTG RNA generates two tetrapeptide repeat proteins (TPRs), polyQAGR and polyLPAC, whose roles in DM2 pathogenesis remain unclear. To define their individual contributions, we expressed codon-optimized polyQAGR and polyLPAC peptides with an ATG start codon in Drosophila melanogaster. Expression of both TPRs reduced viability and lifespan and induced eye degeneration and locomotor defects. We found that polyQAGR accumulated in the nucleolus, disrupted nucleolar integrity, and impaired rRNA processing. It also interfered with autophagy, promoting Atg5 and Atg7 transcription and accumulation of Atg8a- and Ref(2)P-positive aggregates. Consistently, overexpression of Atg8a or Ref(2)P mitigated polyQAGR-induced eye toxicity, whereas knockdown of autophagy genes worsened it. Conversely, polyLPAC increase the cytoplasmic pool of TIAR in human cells and in DM2 patient-derived myoblasts. Together, these findings show that polyQAGR and polyLPAC exert distinct toxic effects that likely converge to drive DM2 pathogenesis and may represent promising therapeutic targets. - Source: PubMed
Publication date: 2026/04/20
Marzullo MartaDe Simone AssiaTerribili MartaDi Salvio MichelaMengistu Degisew YinurSomma Maria PatriziaD'Amico RodrigoCanettieri GianlucaCestra GianlucaCiapponi Laura - Solid tumors are widely known for having hypoxia, which promotes the growth and metastasis of the tumor. It is crucial for research and medicine to comprehend the diverse strategies by which cells sense oxygen and preserve oxygen homeostasis. A rising number of drugs have been found to block hypoxia function through various molecular pathways. For instance, curcumin, a naturally occurring polyphenolic chemical, has the ability to alter the tumor microenvironment and significantly influence the course of malignancy. Studies revealed that curcumin inhibits the signaling pathways including PI3K/Akt, AMPK-mTOR, and NF-κB, which are key factors in preventing hypoxia-induced cancer spread. In this article, we have discussed about the potential use of curcumin as a promising inhibitor of the molecular targets essential for hypoxia cell survival. Therefore, curcumin with strong anticancer effects could work well as a tumor-static drug in chemoprevention by inactivating hypoxia. - Source: PubMed
Singh TejveerSharma DeepikaAdhikari ShubhamKaur GinpreetKaur JagjitRamniwas SeemaRani IshaAggarwal DiwakarKuniyil SreeharshMathkor Darin MansorHaque ShafiulTuli Hardeep Singh - Emerging evidence has linked high dietary fructose intake with adverse health outcomes, yet its role in colitis-associated colorectal cancer (CAC) remains underexplored. Here, we demonstrate that high fructose consumption aggravates intestinal inflammation and significantly promotes tumorigenesis in an AOM/DSS-induced CAC model via activation of the EREG-EGFR signaling axis. We first developed the Food∩TCM database, which encompasses 112 medicine and food homologous TCM, along with their chemical compositions. Using the network-based pharmacological intelligence platform, we identified (kelp) and its bioactive components-fucoidan and dieckol-as promising dietary interventions. Dieckol was found to target the RNA/DNA-binding protein CNBP, which has traditionally been regarded as a positive regulator of pro-inflammatory gene expression, but here was shown to enhance its nuclear localization under inflammatory conditions and thereby repress transcription. Notably, fructose promoted O-GlcNAcylation-mediated stabilization and secretion of EREG in inflammatory fibroblasts, contributing to tumor progression. Together, these findings reveal the tumor-promoting effects of dietary fructose in CAC and highlight CNBP as a key regulator restraining expression. Our findings underscore the significance of integrating food-based strategies into chronic disease prevention, and support the development of -derived compounds as safe, long-term dietary agents for managing colitis-associated colorectal cancer. - Source: PubMed
Publication date: 2026/02/26
Zhang TaoZhou LishaWang BoyangWang MeijingZhu YuyuLiu YitongZhang TingyuLiu QingyuanXiao ChuangKong LingdongXu QiangZhang BoQu JiaoLi ShaoSun Yang