Ask about this productRelated genes to: HEXA antibody
- Gene:
- HEXA NIH gene
- Name:
- hexosaminidase subunit alpha
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 15q23
- Locus Type:
- gene with protein product
- Date approved:
- 2001-06-22
- Date modifiied:
- 2016-10-05
Related products to: HEXA antibody
Related articles to: HEXA antibody
- We demonstrate a convenient approach to synthesize a sustainable and novel hexa-nuclear copper(II) metallamacrocycle, [Cu{NCH(COO)}(phen)], using inexpensive and readily available precursors viz., Cu(NO)·6HO, 5-azidoisopthalic acid and -phenanthroline in a stoichiometric ratio. Structural elucidation by single-crystal X-ray diffraction (SC-XRD) confirms a covalently connected hexagonal chairlike topology in which six Cu(II) centers are interconnected by azidoisophthalate ligands, affording hydrophobic cavities of around 6-7 Å. Significant π-π interactions between ancillary phenanthroline coligands promote clustering among hexa-nuclear metallamacrocycles, thereby enhancing the accessibility of the catalytic site. Leveraging these characteristics, the complex was employed as a heterogeneous catalyst for solvent-free dehydrogenation of secondary alcohols and single pot stepwise process (SPSS) cascade synthesis of quinoline and 1,8-naphthyridine derivatives presenting moderate-to-good yields, satisfactory turnover numbers (TONs) and turnover frequencies (TOFs). The robust catalyst exhibits very good recyclability, and mechanistic insights are revealed through control experiments. This catalytic protocol integrates oxidant-free and solvent-free conditions, minimizes waste generation, ensures high atom economy, and catalyst recyclability enables efficient catalysis under moderate temperatures. - Source: PubMed
Publication date: 2026/05/15
Kanrar GopalJana DebashisSarkar KoushikDey RajarsheeLayek SoumitaPramanik KausikisankarGanguly Sanjib - A highly diastereo- and enantioselective synthesis of hexa-1,5-diene-3,4-diamines has been developed based on cobalt-catalyzed double allylic amination of hexa-1,5-diene-3,4-diyl dimethyl dicarbonate. Consecutive stereocenters can be built under an asymmetric double allylic substitution strategy. Acyclic hexa-1,5-diene-3,4-diamines and cyclic tetrahydroquinoxalines were synthesized in up to 96% yield, >20:1 dr, and normally 99% ee. Cobalt catalysts exhibit a uniquely high reactivity over rhodium and iridium by overcoming the coordinating inhibition of the diene structure of both substrates and products. The chiral hexa-1,5-diene-3,4-diamines were not only used as chiral ligands for Rh-catalyzed conjugated 1,4-addition but also transformed into chiral N-heterocyclic carbene precursors and other chiral products. - Source: PubMed
Publication date: 2026/05/12
Qu ErdongGhorai SamirLi KeLiu MinLi Changkun - Generation of some new complexes of dimethyltin(IV) of sterically congested 4-acylated amphiphilic edaravone having the general formula MeSnLL' and MeSn(L') (where LH= , R = ─CH, LH; R = ─CHCH, LH; R = ─CH, LH; R = p-ClCH─, LH and L' H= R'= p-OCHCH─, L'H; R'= p-CHCH─, L'H) has been accomplished. The newly generated complexes were characterized with the help of spectroscopic analysis [IR and NMR (H, C and Sn)] assisted by DFT and HRMS studies. Sn NMR spectral data of some of these complexes revealed the existence of hexa-coordinated tin centres in these complexes. HRMS studies of some of the representative complexes suggested monomeric nature of these complexes. The optimized molecular structures and optimized energies of one representative ligand L'H and the corresponding complexes, MeSnLL' (Complex 4) and MeSn(L') (Complex 9) were calculated using DFT-B3LYP functional in Spartan 20 computational modelling software. Some representative ligands and their corresponding dimethyltin(IV) complexes were tested for their antioxidant activity by 1,1-diphenyl-2-picrylhydrazyl (DPPH) assay. Mechanistic insights into SET versus HAT pathways for antioxidant activity of dimethyltin(IV) formulations of 4-acylated edaravone derivatives have also been studied. - Source: PubMed
Kumawat AnitaSoni KomalSaxena SanjivJain Asha - The reaction of copper(II) perchlorate hexa-hydrate with 4-pyridone and pyrazine in 1-propanol serendipitously yielded crystals of the solvated title double salt, [Cu(CHNO)(HO)][Cu(ClO)(CHNO)(HO)](ClO)·2CHNO, as a biproduct. The copper cations in both the monometallic complex and the dimeric species exhibit classic Jahn-Teller-like elongations. All coordinating 4-pyridone mol-ecules are in the κ- coordination mode. The dimeric component exhibits both bridging 4-pyridone and perchlorate ligands. Both complexes and the 4-pyridone mol-ecules are bound together by a network of classical hydrogen bonds. The non-coordinating perchlorate ions were modeled as three-site disordered and one of the coordinating 4-pyridone mol-ecules was modeled as two-site disordered. - Source: PubMed
Publication date: 2026/04/14
Turnbull Mark MLandee Christopher PWikaira Jan L - Unlike typical hexa-hydrates, the title compound, [Mg(CHO)(HO)]Br·2CHO or [Mg(HO)(DME)]Br·DME (DME = dimethyl ether, CHO), is a water-poor magnesium(II) complex. The central magnesium cation (site symmetry 1) is coordinated by four water mol-ecules and two mol-ecules of dimethyl ether and adopts a slightly elongated -octa-hedral coordination geometry. The water mol-ecules are linked to outer-sphere bromide anions and additional dimethyl ether mol-ecules O-H⋯Br and O-H⋯O hydrogen bonds. Due to the volatility of dimethyl ether, the presence of coordinating and non-coordinating mol-ecules of this ether makes this solid state structure presented here particularly inter-esting. To investigate the inter-molecular inter-actions leading to this special coordination, a Hirshfeld surface analysis was performed. It showed that the H⋯H inter-actions (70.4%) make the largest contribution to the crystal packing, followed by H⋯Br inter-actions (19.4%), H⋯O inter-actions (10.1%) and Br⋯O inter-actions (0.1%). - Source: PubMed
Publication date: 2026/04/14
Moritz BeataMairath TristanStrohmann Carsten