Ask about this productRelated genes to: PSCA protein
- Gene:
- PSCA NIH gene
- Name:
- prostate stem cell antigen
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 8q24.3
- Locus Type:
- gene with protein product
- Date approved:
- 1999-08-25
- Date modifiied:
- 2016-10-25
Related products to: PSCA protein
Related articles to: PSCA protein
- Lactation curve parameters (LCP) are essential in the refinement of dairy cattle breeding programs due to their relationship with the shape of lactation curves and their biological interpretations. In this context, the primary objectives of this study were to perform genome-wide association studies and functional enrichment analyses of various LCP from random regression models based on 3 nonlinear functions (Wood [WD], Wilmink [WL], and Ali-Schaeffer [AS]) in American Holstein cattle. We used 2,754,840 and 1,642,653 daily milk yield records of 11,139 first and 6,735 s parity cows, respectively, born between 2012 and 2019. A total of 14,464 animals were also genotyped with 60,277 single nucleotide polymorphisms (SNP). The SNP effects, the proportion of the total additive genetic variance explained by them, and their approximate P-values, were estimated for the random regression coefficients based on the GBLUP method. Significant SNP were identified using a modified Bonferroni multiple testing correction that accounts for the number of independent chromosomal segments. Genes and quantitative trait loci located within 100 kb upstream or downstream of the significant SNP were then examined, and functional enrichment analyses were conducted on the candidate genes identified for each LCP. For first parity cows, 81, 128, and 196 significant SNP were identified for the WD, WL, and AS parameters, respectively; whereas for second-parity cows, 120, 125, and 128 significant SNP were identified for the same parameters. The significant SNP were located on 18 autosomal chromosomes. One genomic region (BTA14: 1,801,116 bp) was common to all the parametric functions (WD, WL, and AS). The genomic markers located on BTA15 and BTA19 were unique to the WL parameters; whereas those located on BTA3 and BTA20 were unique to the AS parameters. There were significant SNP located on BTA14 capturing more than 1% of the total additive genetic variance. Twenty candidate genes (i.e., ARC, ADGRB1, C8orf90, CYP11B1, DENND3, GML, GPR20, JRK, LY6D, LY6E, LY6L, LYNX1, LYPD2, PSCA, PTK2, PTP4A3, SLURP1, SLC45A4, THEM6, and TSNARE1) were common to all the parametric functions. No significant gene ontology terms were found for the WD parameter c (i.e., decreasing slope parameter after the lactation peak yield) for first parity cows, and for the AS parameters d and f (parameters associated with the increasing slope) for second-parity cows. Previous reports have identified candidate genes within these genomic regions that possess biological functions related to apoptotic and regulation of gene expression, milk production, clinical mastitis, milk lactose, somatic cell score, fat yield, and udder morphology. This study enabled the identification of several candidate genes associated with LCP, enhancing our understanding of the genomic architecture underlying LCP in American Holstein cattle. - Source: PubMed
Publication date: 2026/05/04
Fotso-Kenmogne Patrick RCarneiro Paulo L SSilva Delvan ALázaro Sirlene FAponte Pedro F CCobuci Jaime AOliveira Hinayah RBrito Luiz F - ( ) infects the gastric epithelium of approximately half of the global population, and is a well-known risk factor for developing gastric cancer. Despite the clinical significance of infection, many genetic factors that contribute to susceptibility remain unidentified. While it is well-established that infection can result in gastritis and peptic ulcers, which may progress to gastric cancer, its causal link to other diseases remains unclear. We performed the genome-wide association study (GWAS) for anti- IgG antibody titers, which were validated as a surrogate marker for infection by the correlation with clinical traits, followed by gene-based and pathway analyses, involving up to 140,863 individuals. This included 56,967 in the discovery phase, and 68,211 in the replication phase from Japanese cohorts, and an additional 15,685 from European populations in a cross-ancestry meta-analysis. We reveal significant associations between infection and polymorphisms in the Human Leukocyte Antigen (HLA) class II region within the Major Histocompatibility Complex (MHC), as well as genes related to innate immunity, including , , , , and . Mendelian randomization (MR) analysis revealed that genetic liability to infection has both positive and negative causal relationships with a variety of diseases, including autoimmune-related diseases such as Type 1 diabetes, Hashimoto's disease, atopic dermatitis, as well as traits like body height and weight. These genetic findings strongly support the notion that genetic liability to infection influences not only gastrointestinal diseases, but also a broader spectrum of health issues, thereby providing valuable insights for public health strategies and personalized medicine approaches. - Source: PubMed
Publication date: 2026/03/30
Kyosaka TomokiNarita AkiraKulski Jerzy KMinn Aye Ko KoMiyake AkimitsuKotsar YuriiHiraide KyogaOjima TakafumiNakatochi MasahiroNamba ShinichiYamaji TaikiSutoh YoichiSasaki YuBroer LindaFrost FabianKoyanagi Yuriko NKasugai YumikoIto HidemiSawada NorieNakano ShioriSuzuki SadaoHishida AsahiKoyama TeruhideKubo YokoFunayama TakamitsuMakino SatoshiShirota MatsuyukiTakayama JunGocho ChinatsuSugimoto SachiyoOtsuka-Yamasaki YayoiTanno KozoAbe YasuhikoNakajima OsamuSpaander Manon C WWeiss StefanLerch Markus MLevy DanielHwang Shih-JenWood Alexis CRich Stephen SRotter Jerome ITaylor Kent DTracy Russell PStocker HannahBrenner HermannLeja MārcisPeculis RaitisHozawa AtsushiKinoshita KengoShimizu AtsushiYamamoto MasayukiMatsuo KeitaroIwasaki MotokiWakai KenjiUeno YoshiyukiFuhler Gwenny MHomuth GeorgPeppelenbosch Maikel P Okada YukinoriKuriyama ShinichiMatsuzaki MotomichiTamiya Gen - Mandibular fractures are a common type of maxillofacial trauma, and accurate localization and classification are crucial for clinical diagnosis. However, the complex morphology of fractures limits existing detection models in effectively representing semantic and positional features. To address this problem, this study proposes PSCA-YOLO, which integrates feature decoupling and coupling mechanisms into YOLO. First, a localization-classification dual-branch decoupling structure is designed, where the classification branch is supervised by binary cross-entropy loss (BCE) to enhance semantic representation, while the localization branch combines distributed focal loss (DFL) and CIOU loss to strengthen spatial learning. Second, a position-semantics feature coupling attention module is introduced to fuse semantic and positional features, improving feature perception. Experiments on mandibular fracture CT dataset, demonstrate strong effectiveness. PSCA-YOLO improves mAP50 by 2.60%, recall by 2.20%, and precision by 2.90% compared with the baseline model. Therefore, the model has positive significance for the clinical diagnosis of mandibular fractures. - Source: PubMed
Publication date: 2026/03/18
Zhou TaoChen KaixiongLu HuilingYu ShiyiChai WenwenLiu Qitao - Fluorescence-guided surgery (FGS) offers a potential strategy to improve complete tumor resection in prostate cancer (PCa); however, clinical application has been limited by an insufficient tumor-to-background ratio (TBR) of available probes. Here, we report the development of GGA-sNIR, a near-infrared (NIR) fluorescent probe engineered by conjugating a high-affinity DNA aptamer specific for a prostate stem cell antigen (PSCA) with a monocarboxy indocyanine green (ICG) derivative. The conjugate adopts a stable three-dimensional structure that not only enables precise target recognition but also protects against nuclease degradation, markedly enhancing its in vivo stability. GGA-sNIR exhibits nanomolar binding affinity ( = 54.91 nM) and is specifically internalized by PSCA-positive cells. In subcutaneous tumor models, the probe achieved a peak TBR of 26 and showed prolonged tumor retention exceeding 48 h. Crucially, in an orthotopic PCa model, GGA-sNIR allowed real-time, high-contrast visualization of tumor margins during laparoscopic surgery, facilitating precise and complete resection. Further validation using ex vivo human lymph node specimens confirmed its ability to selectively detect PSCA-positive metastases. With its ultrahigh contrast, demonstrated efficacy in intraoperative guidance, and strong translational potential, GGA-sNIR represents a promising molecular tool for advancing precision surgery in prostate cancer. - Source: PubMed
Publication date: 2026/03/30
Hu FenLiu YongLi Mao-YinCui Yu-BinWan Yi-QianGao XinHuang Man-NaWang Yu - Prostate cancer (PCa) remains a leading cause of cancer-related mortality in men globally, with castration-resistant prostate cancer (CRPC) representing a particularly challenging stage of disease. Despite therapeutic advances, including androgen receptor inhibitors (ARPIs), taxane-based chemotherapy, and radiopharmaceuticals, durable responses in metastatic CRPC (mCRPC) are limited. - Source: PubMed
Publication date: 2026/03/14
Hakem Zadeh FarigolShah NikitaBird Victoria