Ask about this productRelated genes to: MGMT protein
- Gene:
- MGMT NIH gene
- Name:
- O-6-methylguanine-DNA methyltransferase
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 10q26.3
- Locus Type:
- gene with protein product
- Date approved:
- 1989-10-16
- Date modifiied:
- 2016-10-05
Related products to: MGMT protein
Related articles to: MGMT protein
- The prognosis for very elderly patients with glioblastoma (GBM) is extremely poor. For patients with a high tumor burden, multiple severe comorbidities, and poor physical condition, standard surgery and chemoradiotherapy are often poorly tolerated, and there is an urgent need for effective, low-toxicity palliative treatment options. - Source: PubMed
Publication date: 2026/07/30
Gan LisiMa Yanling - Patients with a history of extracranial cancers (EXCA) who develop new intracranial lesions are commonly presumed to harbour brain metastases, yet primary glioblastoma (GBM) can also arise in cancer survivors. The clinical course, molecular features, and treatment outcomes of GBM in this population remain incompletely characterised. - Source: PubMed
Publication date: 2026/07/29
Kalita OndrejKazda TomasTomoszkova SilviaJancalek RadimSlachta MarekFric DominikKrejci TomasKourilova PavlaCvek JakubDolezel MartinHrabalek LumirLipina Radim - The regulatory approval of the delta-like ligand 3 (DLL3)-directed bispecific T-cell engager tarlatamab has positioned DLL3 as a clinically actionable target in small-cell lung cancer (SCLC), yet whether DLL3 is independently prognostic alongside other therapy-relevant proteins in real-world SCLC cohorts remains unknown. We addressed this using standardized mass spectrometry-based absolute quantitation. - Source: PubMed
Publication date: 2026/06/26
Kim Tae-EunHong Sook HeeAn Ho JungLim Jeong UkPark Chan KwonYoon Hyoung KyuSa Young JoKim Hyo RimKim Tae-Jung - Glioblastoma is the most lethal primary brain tumor of adults, with an age-standardized incidence of 5-7 per 100,000 person-years and a median survival of approximately 15 months despite maximal safe resection, radiotherapy, and temozolomide. Its occurrence in two unrelated cohabiting individuals within a short interval is an uncommon event that inevitably raises the question of shared causation, one that available retrospective methods rarely resolve. - Source: PubMed
Publication date: 2026/07/28
Belotti Evelyn GisellRaccagni Nicholas GiulioBarbotti AriannaDiMeco FrancescoVetrano Ignazio Gaspare - Glioblastoma (GBM) remains highly lethal, and resistance to temozolomide (TMZ) is a major barrier to durable therapeutic response. Although MGMT-mediated DNA repair is a well-established mechanism of TMZ resistance, how GBM cells maintain proteostasis under sustained chemotherapy stress remains less defined. - Source: PubMed
Publication date: 2026/08/04
Kong YangZhu WeiXue KunGao YaMa CaifengTang ShuoSun WeiCui GuangqiangTian XinghanWang Haiying