Ask about this productRelated genes to: GOLM1 protein
- Gene:
- GOLM1 NIH gene
- Name:
- golgi membrane protein 1
- Previous symbol:
- GOLPH2, C9orf155
- Synonyms:
- GP73, FLJ23608, bA379P1.3
- Chromosome:
- 9q21.33
- Locus Type:
- gene with protein product
- Date approved:
- 2001-04-27
- Date modifiied:
- 2015-08-25
Related products to: GOLM1 protein
Related articles to: GOLM1 protein
- To identify oxidative stress (OS)-related genes involved in type 2 diabetes mellitus (T2DM) and screen potential Traditional Chinese Medicine (TCM) candidates for therapeutic use. - Source: PubMed
Jingnan H UMan LiaoZhongwen X IJing SongYining WangTao H E - The microRNA (miR) cluster miR-143/145 represents a well-characterized tumor-suppressive regulatory system with a multifaceted role in prostate cancer. Both miRs are consistently downregulated during disease progression, and their loss is associated with enhanced proliferation, invasion, epithelial–mesenchymal transition, and metastatic competence. Mechanistically, the cluster modulates Rat Sarcoma Viral Oncogene Homolog (RAS)-Mitogen Activated Protein Kinase (MAPK) signaling via Kirsten Rat Sarcoma Viral Oncogene Homolog (KRAS) and Extracellular Signal-Regulated Kinase 5 (ERK5), Tumor Protein p53 (p53)-dependent growth control through MYC Proto-Oncogene, Basic Helix-Loop-Helix Transcription Factor (c-MYC) repression, apoptosis via B-Cell Lymphoma 2 Interacting Protein 3 (BNIP3), and cytoskeleton-associated motility factors including Fascin Actin-Bundling Protein 1 (FSCN1), Human Enhancer of Filamentation 1/ Neural Precursor Cell Expressed, Developmentally Down-Regulated Protein 9 (HEF1/NEDD9), Golgi Membrane Protein 1 (GOLM1), and Fibronectin Type III Domain Containing 3B (FNDC3B). Downregulation is mainly driven by p53 dysfunction, promoter methylation, and RAS-dependent transcriptional repression. A defining feature is pronounced cell-type specificity, with tumor-suppressive effects in epithelial cells and context-dependent pro-angiogenic functions in stromal compartments, with direct translational relevance. Clinically, miR-143/145 contribute to multimarker diagnostic signatures, while reduced miR-145 correlates with adverse pathology and biochemical recurrence. Preclinical replacement strategies reduce tumor growth and enhance docetaxel sensitivity, yet context-dependent effects necessitate cell type-specific delivery. Overall, the cluster represents a central regulator with diagnostic, prognostic, and therapeutic potential requiring prospective validation. - Source: PubMed
Publication date: 2026/04/11
Stope Matthias BErb Holger H H - To investigate the expression of Golgi membrane protein 1 (GOLM1) in oral squamous cell carcinoma (OSCC) and its effects on proliferation, migration, invasion, and epithelial-mesenchymal transition (EMT) in OSCC cells and the underlying mechanisms. - Source: PubMed
Li ShouchengWen CaiYu LiChen JunliangFeng Hao - Exanthem subitum (ES), a benign febrile exanthematous disease, is caused by primary human betaherpesvirus 6B (HHV-6B) infection. It may cause neurological complications, including complex febrile seizures (cFS), acute encephalopathy with biphasic seizures, and late reduced diffusion (AESD). cFS resolves spontaneously; however, AESD can pose severe sequelae. We aimed to elucidate AESD pathogenesis using a proteomic analysis. - Source: PubMed
Publication date: 2026/02/24
Kawamura YoshikiYamaguchi HisateruNishioka TomokiKiribuchi MaoYun AyanoMiura HirokiKondo YotaroItano MasatoHigashimoto YukiIhira MasaruKawada Jun-IchiYoshikawa Tetsushi - Diffuse large B-cell lymphoma (DLBCL) is a clinically and molecularly heterogeneous malignancy with variable outcomes. Identification of reliable biomarkers is critical for risk assessment and targeted therapy. - Source: PubMed
Publication date: 2026/02/25
Li ChiHan XinliHu XiaoshuangDu ShuruiAn PeihanWang Dao