Ask about this productRelated genes to: FHIT protein
- Gene:
- FHIT NIH gene
- Name:
- fragile histidine triad
- Previous symbol:
- -
- Synonyms:
- FRA3B, AP3Aase
- Chromosome:
- 3p14.2
- Locus Type:
- gene with protein product
- Date approved:
- 1996-10-18
- Date modifiied:
- 2019-04-17
Related products to: FHIT protein
Related articles to: FHIT protein
- To evaluate whether virtual reality-based vestibular rehabilitation (VR-VestRehab) added to home-based vestibular rehabilitation (HB-VestRehab) improves postural control, symptom severity, and psychological outcomes in vestibular migraine (VM). - Source: PubMed
Publication date: 2026/08/19
Kirazli GulceUzumcugil HaleKapusizoglu SumeyyeCinar EceOzdemir Huseyin NezihSaruhan Durmaz GulsumKaya IsaKirazli TayfunGokcay FigenCelebisoy Nese - Decapping Scavenger (DcpS) enzyme, a pyrophosphatase involved in mRNA regulation via mRNA cap degradation, has been identified as a promising oncology target in fragile histidine triad (FHIT) deficient cancers such as AML and GBM but remains underexplored in broader solid tumor indications. We have discovered a novel DcpS inhibitor, compound 17, which has a differentiated binding mode relative to known inhibitors, engaging the second nucleotide-binding domain of the mRNA cap substrate. Compound 17 possesses superior levels of potency in NSCLC A549 cell line relative to known inhibitors and demonstrates excellent selectivity against DcpS-insensitive cell lines, high levels of bioavailability in preclinical species, and mitigated hERG liabilities. Finally, compound 17 demonstrates oral dose-dependent efficacy in two solid tumor xenograft models, A253 and EBC-1, highlighting the promise of DcpS as a novel target in FHIT low/deficient solid tumors. - Source: PubMed
Scholz Spencer ODudnik Alexander SVasilopoulos AristidisJia Zhaozhong JAlbertson AnnaBrown Brian SChen LiyeLi RenheMa GaoyuanWang LongchengOkano AkinoriZhao XianruiJiang XingyuKarmel CalebBrady Patrick BLai ChunqiuDeokar HemantkumarDeAnda FelixRoy SomduttaMayekar ManasiChoi HanaLin LouisBelair David GJoshi AnandYoon Woo HyunMontano AndreaXie XiaopingNguyen HenryLi Haiyan SPan ChinDanna BenGurbani DeepakLi JingzhiKorepanova AllaLi TaoGururaja TarikereDing Rong-XianJain RinkuMartin Ruth LKohnken RebeccaRivkin Alexey - NIT1 is a tumor suppressor which functions as a metabolite repair enzyme to process deaminated glutathione (dGSH). Missense variants in NIT1 were analyzed from the COSMIC database to assess their structural and functional consequences. Of 59 missense variants identified, nine were flagged as deleterious. Homology modeling onto the NitFhit structure revealed two mechanistically distinct classes: active site mutations predicted to disrupt the conserved Glu-Lys-Cys (EKC) catalytic triad and surface mutations predicted to perturb the Nit1-Fhit interaction interface. This work provides a structural basis for understanding NIT1 loss of function in human cancer. - Source: PubMed
Publication date: 2026/07/22
Parajuli AnupPhan HungWalsh Susan - [This retracts the article DOI: 10.3892/ol.2018.9696.]. - Source: PubMed
Publication date: 2026/07/20
Xu ZhengfengWu JiajunCai PanZhou XiaoxiaoYi CunguoWang Bin - In interictal Ménière's disease (MD), a caloric-vHIT dissociation is well established: caloric testing reveals vestibular hypofunction, yet video head impulse test (vHIT) gains in the lateral canal are preserved. Whether this preservation corresponds to preserved functional gaze stabilization remains unknown. This preliminary, exploratory study compared affected and unaffected ear responses of dynamic visual acuity (DVA), functional head impulse test (FHIT), and vHIT in interictal MD, and evaluated the clinical value of each measure. - Source: PubMed
Publication date: 2026/07/13
Goto FumiyukiTsuda YukikoOkami KenjiWasano Koichiro