Ask about this productRelated genes to: BM40 protein
- Gene:
- RNPC3 NIH gene
- Name:
- RNA binding region (RNP1, RRM) containing 3
- Previous symbol:
- -
- Synonyms:
- KIAA1839, FLJ20008, RBM40, SNRNP65
- Chromosome:
- 1p21.1
- Locus Type:
- gene with protein product
- Date approved:
- 2002-09-17
- Date modifiied:
- 2015-11-05
Related products to: BM40 protein
Related articles to: BM40 protein
- The RNA-binding region-containing protein 3 (RNPC3) protein acts as a molecular bridge, promoting U11/U12 RNP complex formation. In previous reports, patients with systemic sclerosis (SSc) with anti-RNPC3 autoantibodies had an increased risk of interstitial lung disease (ILD), severe gastrointestinal (GI) disease, and cancer. The aim of this study was to compare phenotypic features of patients with mixed connective tissue disease (MCTD) with and without anti-RNPC3 autoantibodies. - Source: PubMed
Jalaledin Darya SEl Kamouni HajarAlbert AlexandraHoa SabrinaBourré-Tessier JosianeRich EricGoulet Jean-RichardKoenig MartialPérez GemmaChoi May YTroyanov YvesSatoh MinoruFritzler Marvin JSenécal Jean-LucLandon-Cardinal Océane - Anti-cytolethal distending toxin (CDT) antibodies may serve as biomarkers for post-infectious autoimmunity and aid clinical risk stratification. We aimed to determine the prevalence of anti-CDT antibodies in a large, well-characterized cohort of systemic sclerosis (SSc) patients and examine associations with gastrointestinal (GI) and extraintestinal clinical features and SSc-related antibodies. - Source: PubMed
Di Ciommo Francesca RomanaCasciola-Rosen LiviaAyla Ali YagizBalar AshishShah Ami AHughes MichaelMorales WalterPimentel MarkAdler Brittany LMcMahan Zsuzanna H - Minor splicing is an under-appreciated splicing system required for the correct expression of ~700 genes in the human genome. This small subset of genes (0.35%) harbours introns containing non-canonical splicing sequences that are recognised uniquely by the minor spliceosome and cannot be processed by the major spliceosome. Using in vivo zebrafish and mouse cancer models, we show that heterozygous expression of Rnpc3, encoding a unique protein component of the minor spliceosome, restricts the growth and survival of liver, lung and gastric tumours without impacting healthy cells. RNPC3 knockdown in human lung cancer-derived A549 cells also impairs cell proliferation and RNA-seq analysis reveals a robust and selective disruption to minor intron splicing and transcription-wide effects on gene expression. We further demonstrate that these perturbations are accompanied by DNA replication stress, DNA damage, accumulation of TP53 protein and activation of a Tp53-dependent transcriptional program that induces cell cycle arrest and apoptosis. Together our data reveal a vulnerability of cancer cells to minor splicing inhibition that restricts tumour growth. - Source: PubMed
Publication date: 2025/07/07
Doggett KarenMorgan Kimberly JOlthof Anouk MMieruszynski StephenWilliams Benjamin BGarnham Alexandra LMilevskiy Michael J GWhitehead LachlanCoates JanineBuchert MichaelO'Donoghue Robert J JHall Thomas EPutoczki Tracy LErnst MatthiasSutherland Kate DKanadia Rahul NHeath Joan K - Functional antibodies play a role in SSc gastrointestinal (GI) disease, but their clinical relevance is unclear. We examined GI and extraintestinal features associated with anti-muscarinic-3 receptor (M3R) antibodies in SSc patients. - Source: PubMed
Ayla Ali YKalavar Naveen RPimentel MarkMorales WalterHummers Laura KShah Ami AHughes MichaelMcMahan Zsuzsanna H - Germinal center (GC) response ensures the generation of diverse and high-affinity antibodies during the T cell-dependent (TD) immune response. This process is controlled by coordinated transcriptional and posttranscriptional gene regulatory mechanisms. Minor intron splicing is known to be involved in posttranscriptional regulation of gene expression. RNA-binding region (RNP1, RRM) containing 3 (RNPC3) is a minor spliceosome component involved in stabilizing the U11/U12 di-snRNP complex, which is essential for minor intron splicing. However, it remains unclear if RNPC3 and RNPC3-related gene regulatory mechanisms are important for the TD immune response. In this study, we conditionally ablated RNPC3 in activated B cells and showed that the mutant mice had defective antibody generation due to impaired GC B cell response. We demonstrate that RNPC3 deficiency inhibits the proliferation and promotes the apoptosis of activated B cells. Mechanistically, we show that RNPC3 regulates the development of GC B cells in a minor spliceosome-dependent manner by controlling the removal of minor introns from minor intron-containing genes associated with cell proliferation and apoptosis. Our study thus uncovers a previously unappreciated role for RNPC3 in regulating GC B cell response. - Source: PubMed
Wang JingRuan Gui-XinLi YuxingXiao XiongZhu ZhijianChen WenjingHuang HengjunZhang RuiWang RuisiChen MeiyuanGuo LingLi YanXu ShengliOu Xijun