Ask about this productRelated genes to: ApoA1 protein
- Gene:
- APOA1 NIH gene
- Name:
- apolipoprotein A1
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 11q23.3
- Locus Type:
- gene with protein product
- Date approved:
- 2001-06-22
- Date modifiied:
- 2019-04-23
Related products to: ApoA1 protein
Related articles to: ApoA1 protein
- The significance of cholesterol efflux as a predictor of coronary artery disease (CAD) remains controversial. The intracellular cholesterol export via the ABCA1 transporter involves the acceptance of cholesterol by both lipid-free apolipoprotein A-I and high-density lipoproteins (HDL). An estimate of the efficiencies of two reactions is thus required. - Source: PubMed
Baserova Veronika BPopov Mikhail ADergunov Alexander D - Obesity and depression have a bidirectional relationship. Previous work has shown that obesity increases the risk of depression, while atypical depression can elevate the risk of obesity. This study aimed to investigate the associations between anthropometric markers, lipid and insulin resistance biomarkers, inflammatory cytokines, and adipokines with depressive symptom severity in individuals with newly diagnosed metabolic syndrome (MetS). - Source: PubMed
Kitov SpasDeneva TanyaKitova Maria-FloranceKitova LyudmilaStoyanova KristinaPetrova IlianaStoyanov Drozdstoy - GBS (Guillain-Barré syndrome) is an acute immune-mediated peripheral neuropathy whose pathological mechanisms remain incompletely understood. Our study aimed to explore the intrinsic link and potential mechanisms between circulating dyslipidemia and immune metabolic remodeling of monocytes in GBS. Clinical data from 163 patients diagnosed with classic GBS and 169 healthy controls were analyzed to examine the correlations between their lipid profiles and immune cell features. Leveraging our team's previously published single-cell RNA sequencing (scRNA-seq) dataset for GBS, we characterized the subpopulations, functional features, and differentiation trajectories of peripheral blood monocytes. Furthermore, through transcriptional regulatory network analysis, we identified key transcription factors governing these processes. Compared to healthy controls, GBS patients displayed a distinct dyslipidemia characterized by elevated triglycerides (TG), very low-density lipoprotein (VLDL), and residual cholesterol (RC), but decreased high-density lipoprotein (HDL) and apolipoprotein A1 (APOA1). This lipid profile coincided with higher monocyte counts in peripheral blood, suggesting a synergistic relationship. The scRNA-seq analysis results indicate that the composition of peripheral blood monocyte subsets in GBS patients undergoes fundamental remodeling. This is characterized by a significant expansion of CD14CD163 monocytes lipid metabolism-active monocytes and pro-inflammatory CD14CD169 monocytes, while the proportion of classical monocytes sharply decreases. Pseudo-time trajectory analysis revealed a differentiation pathway from classical monocytes to CD14CD163 monocytes via CD14CD169 and intermediate monocytes. This pathway was characterized by an initial increase followed by a decrease in pro-inflammatory activity, coupled with a progressive enhancement in lipid metabolism activity. Transcriptional network analysis identified CEBPB as a core transcription factor potentially associated with the phenotypic conversion of monocyte subsets, likely mediated by synergistic regulation of genes involved in lipid metabolism and cell differentiation. In summary, GBS is characterized by synergistic dyslipidemia and monocyte remodeling. The pathological signature involves lipid metabolic reprogramming in the CD14CD163 monocytes and pro-inflammatory phenotypes in the CD14CD169 monocytes. The transcription factor CEBPB is associated with this phenotypic conversion by regulating lipid metabolism and differentiation genes, revealing molecular targets for precise GBS diagnosis and therapy. - Source: PubMed
Publication date: 2026/04/13
Chen YuanSun ShuanghongJia FeihongLi MengWang HainingSong JiheChen HongpingZhong Di - To investigate metabolic reprogramming-especially pyruvate metabolism-in hepatocellular carcinoma (HCC) before and after immune checkpoint inhibitor (ICI) therapy, construct a metabolism-related prognostic model, and evaluate the therapeutic potential of targeting LDHA. - Source: PubMed
Publication date: 2026/04/13
Li XinTang LingCao JuLiu Yao - Apolipoprotein A-I (ApoA-I), the principal protein component of high-density lipoproteins (HDL), plays a pivotal role in cardiovascular physiology and has gained increasing attention in atherosclerotic cardiovascular disease (ASCVD). Its involvement extends beyond lipid transport to include anti-inflammatory and antioxidant mechanisms. - Source: PubMed
Habib AwaisKhan Muhammad Saood MoazzamAneeq AhmadTahir Hafiz Muhammad TalhaMehmoodi AminMalik JahanzebPerveen Abida