Ask about this productRelated genes to: SOD1 antibody
- Gene:
- SOD1 NIH gene
- Name:
- superoxide dismutase 1
- Previous symbol:
- ALS, ALS1
- Synonyms:
- IPOA
- Chromosome:
- 21q22.11
- Locus Type:
- gene with protein product
- Date approved:
- 1986-01-01
- Date modifiied:
- 2019-04-23
Related products to: SOD1 antibody
Related articles to: SOD1 antibody
- The study investigated the effects of gallic acid (GA) and methyl gallate (MG), in combination with cisplatin (CIS), on apoptotic protein expression, antioxidant gene expression and cell migration in HeLa cervical cancer cells. HeLa cells were treated with the combinations CIS-GA and CIS-MG prior to further analysis. The expression of apoptotic proteins (Bax, Bcl-2, caspase-3, caspase-9 and p53) was determined via western blot analysis. Antioxidant gene expression in treated HeLa cells was then assessed using reverse transcription quantitative polymerase chain reaction (RT-qPCR). The migration-inhibitory effect of the compound combinations was assessed using a scratch wound-healing assay. Treatment with CIS-GA significantly upregulated the expression of p53, Bax, caspase-3 and caspase-9, and downregulated the expression of Bcl-2. Results from RT-qPCR revealed downregulation of human catalase () in the CIS-GA group and no changes in superoxide dismutase 1 () expression in either the CIS-GA or CIS-MG groups. Moreover, lower wound closure percentages were observed after 24-hour incubation in both treated groups, indicating inhibited cell migration. These findings suggest that GA and MG combined with CIS upregulate apoptotic proteins by downregulating antioxidant gene (). - Source: PubMed
Publication date: 2026/03/31
Abdullah HasmahMamat NorlidaSazeli SyahirahHapidin HermiziSulong SarinaIsmail IllyanaElsori Deena - Per- and polyfluoroalkyl substances (PFAS), especially the newly adopted chlorinated polyfluoroalkyl ether sulfonate (6:2 Cl-PFESA, trade name F-53B), have raised significant concerns because of their environmental persistence and potential toxicity. This has prompted the need to evaluate their effects on vertebrate development, particularly skeletal formation. The aim of this study is to investigate the impact of early-life exposure to F-53B on the skeletal development of zebrafish offspring. Initially, we established the median lethal concentration (LC) of F-53B at 15.21 μg/mL through a 96-hour exposure experiment. Based on this, we set a maximum treatment concentration of 10 μg/mL for further investigations. Subsequently, zebrafish embryos exposed from fertilization exhibited marked developmental deformities at 10 days post-fertilization (dpf), including a 23.3% incidence of spinal curvature and stunted growth. Alcian blue and alizarin red staining showed significant reductions in cartilage and bone development compared to controls. Reactive oxygen species (ROS) staining revealed a significant increase in ROS fluorescence intensity compared to the control group. Quantitative real-time PCR (qPCR) indicated downregulation of oxidative stress genes (cat, mt2, and sod1), osteogenic genes (alp, ocn, and runx2a), and chondrogenic genes (sox9b, col1a1a, and col2a1a) in treated groups. These findings indicate that early-life exposure to F-53B can induce developmental abnormalities in zebrafish offspring, particularly spinal curvature, and adversely affect both cartilage and bone development. This may be related to F-53B inducing dysregulation of gene expression in offspring zebrafish skeletal development through oxidative stress. Future research should further elucidate the underlying molecular mechanisms and long-term implications of such exposure on skeletal health. - Source: PubMed
Publication date: 2026/04/29
Cao JiaHuang XixiLi HuiWu MeiqinLiu Chao - Inflammatory bowel disease (IBD) arises from a persistent imbalance between oxidative stress and immune homeostasis, driving tissue injury and chronic intestinal inflammation. Natural polyphenols are increasingly recognized as powerful modulators of redox and immune pathways, yet the bioactivity of complex, tannin-rich extracts remains largely overlooked. Among these, chestnut wood extract (CWE) particularly rich in highly soluble tannins, represents a valuable yet underexplored reservoir of bioactive molecules. This study aimed to characterize the phytochemical diversity of CWE and evaluate its anti-inflammatory, antioxidant, and epithelial-protective properties. - Source: PubMed
Publication date: 2026/04/29
Lambert DylanBuisine MathysBillamboz MurielJawhara Samir - : Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder that affects upper and lower motor neurons with variable cognitive impairment. Despite its rarity, ALS has a major social and economic impact and increasing incidence worldwide. There are few population-based studies of ALS in Brazil. : We present a descriptive and quantitative study, with a retrospective and prospective design, of patients with ALS followed at the Walter Cantídio University Hospital (HUWC) from January 2013 to December 2023, with the aim of describing the clinical, epidemiological, and genetic aspects of ALS in this population, as well as the ALS epidemiology within the state of Ceará, Brazil. : Two hundred and forty patients had their medical records analyzed. One hundred and thirty-four (55.8%) cases were male, with a male to female ratio of 1.3:1. The mean age of symptom onset was 56.39 ± 13.05 years. 92.1% (221) of cases were sporadic, 7.9% (19) were familial. Spinal onset was most common (72.1%). Genetic mutations were found in 10 patients, with SOD1 mutations (variant: c.358G > C; p.Val120Leu) being the most common. Using riluzole prescription data, the prevalence and incidence of ALS in 2022 were estimated at 2.32 and 0.8/100.000/inhabitants, respectively. : The epidemiology of ALS in the state of Ceará is similar to what has been reported in prior studies from Brazil and other developing countries; SOD1 mutations were the most prevalent genetic subtype. - Source: PubMed
Publication date: 2026/04/29
Fernandes José Marcelino AragãoDutra Junior Avelino MissialdesThomas Florian PGondim Francisco De Assis Aquino - Chronic kidney disease (CKD) is a systemic condition associated with inflammation and oxidative stress, affecting organs beyond the kidneys. Although rarely emphasized, the eyes may also be affected but underlying molecular mechanisms remain largely unexplored. The gut-kidney and gut-eye axes are emerging as therapeutic targets with prebiotics like ResistAid®-a Larch Arabinogalactan (LAG) supplement with antioxidant and immunomodulatory effects-showing promise through gut microbiota modulation. This study assessed ResistAid®'s effects on ocular gene expression in a CKD rat model. Twenty four Wistar rats were assigned to Sham (S), Sham + Treatment (ST), Nephrectomized (N), Nephrectomized + Treatment (NT) ( = 6 each). CKD was induced by 5/6 nephrectomy. The treatment was administered via gavage for 30 days at a dose of 5.35 mg/day, adapted from human recommendations. At day 30, blood and tissues were collected. Expression of antioxidant enzymes () and other genes () was analyzed by qPCR. Biochemical and well-being assessments were also conducted. Nephrectomy, regardless of treatment, increased and expression in eye and blood; Specific to NT animals, ocular , and expressions were markedly elevated when compared with N animals and blood and ocular expressions were not elevated, differing from N animals. No significant changes were observed between the S and ST groups. CKD induces systemic oxidative and inflammatory responses. ResistAid® partially mitigated these effects in blood and eye, suggesting systemic and local benefits, possibly via gut microbiota modulation. - Source: PubMed
Publication date: 2026/04/29
Alves Reis Pedro HenriqueDestro Isabela de PaulaLamy Ingrid BertolliniPetri GiulianaSilvestri Estella FreitasTrufelli Isabella Dudjak RosaAlves Beatriz da Costa AguiarLima Vagner Loducada Veiga Glaucia LucianoFonseca Fernando Luiz Affonso