Ask about this productRelated genes to: ROCK2 antibody
- Gene:
- ROCK2 NIH gene
- Name:
- Rho associated coiled-coil containing protein kinase 2
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 2p25.1
- Locus Type:
- gene with protein product
- Date approved:
- 1999-04-23
- Date modifiied:
- 2016-10-05
Related products to: ROCK2 antibody
Related articles to: ROCK2 antibody
- To investigate the genetic characteristics of copy number variations (CNVs) in families with concomitant exotropia. A family-based molecular genetic study. The study included 25 unrelated concomitant exotropia families who visited Tianjin Eye Hospital between August 2019 and August 2021. Patients and healthy individuals from these families were included as subjects. Clinical data were collected through detailed medical history interviews, family history documentation, and comprehensive ophthalmic and systemic examinations to confirm the diagnosis of probands and affected family members. Peripheral blood samples were obtained for genomic DNA extraction, followed by single nucleotide polymorphism (SNP) genotyping using single nucleotide polymorphism array (SNP array). CNV detection was performed using the PennCNV tool. Gene enrichment analysis and protein-protein interaction (PPI) network analysis were conducted to explore the biological functions of candidate genes and their potential pathogenic mechanisms. The Benjamini-Hochberg method was used for multiple comparison correction, and node permutation randomization test was used for significance assessment of network analysis. A total of 74 subjects from 25 families with concomitant exotropia were enrolled in the study, including 55 patients with concomitant exotropia. Among all subjects, 33 were male (44.6%) and 41 were female (55.4%). Among the 55 patients with concomitant exotropia, 27 were male (49.1%) and 28 were female (50.9%). The age at onset was 6.0 (3.3, 10.0) years. Using the prism and alternate cover test, the deviation angle was -30 (-39, -25) at distance (6 m) and -35 (-40, -30) at near (33 cm). Based on the SNP genotyping technique, this analysis identified seven novel concomitant exotropia-associated CNVs, located at chromosomal regions 2p25.1, 20q13.33, 15q22.2, 7q34, 13q14.2, 8p21.1, and 3q25.33. Analysis of familial distribution showed that the CNV at 2p25.1 had the highest detection rate (28%), being present in seven families. Co-segregation analysis revealed that CNVs at 15q22.2, 7q34, and 13q14.2 exhibited complete co-segregation with the disease phenotype (100% penetrance), whereas regions at 2p25.1, 20q13.33, 8p21.1, and 3q25.33 showed incomplete penetrance of 73.3%, 92.3%, 83.3%, and 80%, respectively. These seven CNVs covered the exonic regions of nine protein-coding genes, including and . Gene enrichment analysis revealed that these genes were enriched in pathways associated with muscular movement regulation (<0.001). Gene intersection analysis identified two genes ( and ) that overlap with genes related to oculomotor neural development, and four genes ( and ) that overlap with genes related to extraocular muscle development. PPI analysis revealed that ROCK2, BRAF, RB1, PBK, and ESCO2 proteins formed a significant functional cluster with a higher number of edges than random expectation(=0.09±0.42,=0.002,=9.31). This study reports seven CNVs associated with concomitant exotropia. These CNVs exhibit genetic characteristics of scattered chromosomal distribution, variable penetrance and functional clustering of target genes. - Source: PubMed
Zhou W TZhao Y ZLi JShi X F - Sinomenine (SIN) exhibits inhibitory effects on different types of tumor cells, containing gastric cancer (GC). However, the anti-cancer molecular mechanism of SIN in GC is still not fully revealed. - Source: PubMed
Publication date: 2026/04/28
Zhang ChongxinYang PengfeiZhang FanXiang ZhigangLuo JiashunJiang XiaojingLiu Yang - Systemic sclerosis (SSc) is a severe autoimmune disease characterised by progressive fibrosis driven by fibroblast activation. Primary cilia, key hubs for profibrotic signalling, are markedly shortened in SSc fibroblasts, but the mechanisms underlying this phenotype remain unclear. This study aimed to define the signalling pathways responsible for primary cilia shortening and fibroblast activation in SSc. - Source: PubMed
Publication date: 2026/05/07
Wells RebeccaCaballero-Ruiz BegoñaMulipa PanjiTimmis Alex JTeves Maria EVarga JohnDel Galdo FrancescoRoss Rebecca LRiobo-Del Galdo Natalia A - Cerebral ischemia/reperfusion (I/R) injury represents a significant challenge to recanalization therapy for ischemic stroke and is critically influenced by microglial polarization. Although inhibition of Rho-associated protein kinase (ROCK) has been shown to mitigate cerebral I/R injury and associated neuroinflammation, its specific effect on the balance between M1 and M2 (anti-inflammatory) microglial polarization remains incompletely understood. This study aimed to elucidate the role and underlying mechanism of ROCK inhibition in regulating M1 and M2 microglial polarization, using the classical antidepressant fluoxetine as a positive control. - Source: PubMed
Publication date: 2026/05/06
Wang ZiyuXu XinWang LeshuGuo BaoyunHu FalanLi ZiyanChen JinhuaWen Jiyue - Pulmonary arterial hypertension (PAH) is a severe and progressive cardiopulmonary disorder with limited treatment options. (Merr.) Sealy (CP) contains multiple flavonoids and other phytochemicals, but its active compounds and molecular mechanisms in PAH remain unclear. Active compounds of CP were screened by comprehensive literature mining and absorption, distribution, metabolism, and excretion (ADME) evaluation. PAH-related hub targets were identified from transcriptomic data using weighted gene co-expression network analysis (WGCNA), machine learning, and external validation. Functional enrichment, immune infiltration, and single-cell RNA-sequencing analyses were performed to characterize their biological roles and cellular localization. Molecular docking and molecular dynamics simulations assessed compound-target interactions. The effects of CP were further evaluated in hypoxia-induced rat pulmonary artery smooth muscle cells (RPASMCs). Five core bioactive compounds were identified, among which luteolin and quercetin were prioritized for further analysis. and were screened as hub targets. Bioinformatic analyses suggested that these targets were mainly associated with the "Lipid and atherosclerosis" pathway, metabolic reprogramming, and modulation of the immune microenvironment. Single-cell analysis showed broad expression of and enrichment of in fibroblasts and endothelial cells. Molecular docking and molecular dynamics simulations supported stable binding of luteolin to HSP90AA1. In vitro, CP extract inhibited hypoxia-induced hyperproliferation of RPASMCs and reduced HSP90AA1 protein expression. HSP90AA1 may represent a candidate molecular mediator of CP in PAH, and CP inhibited hypoxia-induced RPASMC proliferation in association with downregulation of HSP90AA1. - Source: PubMed
Publication date: 2026/04/21
Chen XinyingZhou LipengZhu ChenghaoSun Zhirong