Ask about this productRelated genes to: Phospho STAT3 antibody
- Gene:
- STAT3 NIH gene
- Name:
- signal transducer and activator of transcription 3
- Previous symbol:
- -
- Synonyms:
- APRF
- Chromosome:
- 17q21.2
- Locus Type:
- gene with protein product
- Date approved:
- 1995-11-08
- Date modifiied:
- 2019-04-23
Related products to: Phospho STAT3 antibody
Related articles to: Phospho STAT3 antibody
- Capilliposides (CPSs) are oleanane-type triterpene saponins derived from , a traditional Chinese herb widely utilised for treating inflammatory illnesses, cancer, and arthritis disorders. CPSs have been reported to exhibit anticancer activity against different cancers, including lung, prostate, ovarian, colorectal, nasopharyngeal, and breast cancers. Mechanistically, CPSs have been suggested to induce apoptosis regulating oxidative stress and mitochondrial pathways, as well as inhibiting angiogenesis and metastasis, promoting cell cycle arrest, and interfering with PI3K/Akt/mTOR, MAPK, and JAK/STAT3 signalling cascades. Additionally, CPSs have demonstrated anti-inflammatory and cytoprotective properties; they lowered oxidative stress, relieved experimental colitis, preserved intestinal barrier integrity, and regulated gut microbiota. This review discussed the reported data on the separation, chemistry, pharmacokinetics, and biological activities of CPSs. Although CPSs represent prominent multi-target natural triterpenes, current findings are largely preclinical and require further interpretation. Future research and clinical trials are recommended to confirm their safety and therapeutic potential. - Source: PubMed
Publication date: 2026/05/07
Ibrahim Sabrin R MMohamed Gamal ASharif AliFayed Marwa A AFouda Wafaa MMohamed Hagar M - Colorectal cancer (CRC) remains a major global and Malaysian public health concern, with increasing recognition of gut dysbiosis as a contributor to colorectal tumorigenesis. This review examines fermented durian tempoyak as a culturally relevant, probiotic-rich traditional food with potential application in CRC prevention through gut microbiome modulation. - Source: PubMed
Publication date: 2026/05/07
Ng Wing SoonNg Nancy Choon-SiWong Rebecca Shin-YeeGoh Bey Hing - Glaucocalyxin D (GLD), an ent-kaurane diterpenoid isolated from species, exhibits extensive pharmacological potential; however, its mechanism of action against acute myeloid leukemia (AML) remains to be elucidated. The present study employed a combined network pharmacology and experimental approach to elucidate the anti-AML mechanisms of GLD. Potential targets were identified using database mining and a protein-protein interaction network was constructed. The Gene Ontology and the Kyoto Encyclopedia of Genes and Genomes enrichment analyses highlighted the JAK-STAT signaling pathway as central to action by GLD. Molecular docking predicted stable binding of GLD to core targets, including STAT3. Experimental validation in HEL and K562 AML cells demonstrated that GLD potently and dose-dependently inhibits cell proliferation, with efficacy similar to the standard chemotherapeutic agent doxorubicin. Mechanistically, GLD suppressed the phosphorylation of JAK2 and STAT3. GLD also induced mitochondrial apoptosis by modulating the Bcl-2/Bax ratio and triggered G/M phase arrest by downregulating cyclin B1 and CDK1. These findings delineated a coherent mechanism whereby GLD exerts anti-leukemic effects by inhibiting the JAK-STAT pathway, supporting its potential as a novel lead compound for AML therapy in the future. - Source: PubMed
Publication date: 2026/04/27
Chen LianYang WeixianZhang WeiqingLuo HengYan Chen - Epidermal growth factor receptor (EGFR) "membrane-cytoplasmic-nuclear translocation" occurs in EGFR-19del lung adenocarcinoma (LUAD) following resistance to tyrosine kinase inhibitors (TKIs). This study aimed to elucidate the mechanism of TKI resistance conferred by nuclear EGFR-19del. - Source: PubMed
Publication date: 2026/04/08
Feng YuhengWang MinghaoLiu YangWu XinhaoLin XuyongHan QiangRong Xuezhu - Intrauterine inflammation, commonly presenting as chorioamnionitis, is variably linked to preterm birth, neonatal infections and postnatal chronic inflammatory disorders. However, the effects of systemic maternal inflammation on exposed fetuses and offspring are less clear. We previously reported inflammatory responses in murine pups born after brief gestational exposure to experimental maternal inflammation. These findings led us to hypothesize that fetal exposure to maternal inflammation could lead to persistent alterations in postnatal immunity. - Source: PubMed
Publication date: 2026/04/27
Nichols Casey MSabic DajanaMcQuillan Jay JKoenig Joyce M