Ask about this productRelated genes to: Nck2 antibody
- Gene:
- NCK2 NIH gene
- Name:
- NCK adaptor protein 2
- Previous symbol:
- -
- Synonyms:
- NCKbeta
- Chromosome:
- 2q12.2
- Locus Type:
- gene with protein product
- Date approved:
- 1998-10-29
- Date modifiied:
- 2016-10-05
Related products to: Nck2 antibody
Related articles to: Nck2 antibody
- Discoidin domain receptor 1 (DDR1) is a collagen-activated receptor tyrosine kinase that plays an important role in epithelial cell regulation; its function in cancer appears to be dependent on tumour type. This study investigated DDR1 expression in large numbers of breast ( = 1416) and ovarian ( = 450) tumours using immunohistochemistry. In addition, RNA sequencing was conducted on knockdown breast and ovarian cancer cell lines. In breast cancer, high DDR1 expression was significantly associated with poor patient survival in ER-positive disease and low expression was associated with poor patient survival in ER-negative disease. In ovarian cancer, high DDR1 expression was associated with improved patient survival. In knockdown IGROV1 ovarian cancer cells, 770 transcripts were differentially expressed, whilst in knockdown T47D breast cancer cells, 3647 transcripts were differentially expressed. Only 149 genes were shared, suggesting that DDR1 drives distinct transcriptional programmes across cancer types. Shared genes between T47D and IGROV1 knockdown cells include key regulators of signalling, metabolism, and cytoskeletal organisation such as , , , and . Gene Ontology analysis revealed significant enrichment of epithelial cell migration pathways in both cell lines. Current protein expression and transcriptomic data highlight the important prognostic role of DDR1 expression in breast and ovarian cancer and provide hypothesis-generating insights into the contextual and transcriptomic differences between the two cancer types. - Source: PubMed
Publication date: 2026/06/30
Alshammari KhalidDeen SuhaEllis Ian ORakha Emad AGreen Andrew RMartin Stewart GStorr Sarah J - Genome-wide studies in late-onset Alzheimer's disease (LOAD) have uncovered many risk loci, yet identifying the causal genes and clarifying how these genetic signals connect to molecular and cellular mechanisms relevant to AD pathogenesis remains challenging. - Source: PubMed
Publication date: 2026/03/30
Waghmare Swapnil GKrishna Meera MMaccoux Emily CFranitza Ariel LLink Brian ALezi E - The rising demand for organ transplantation far exceeds the supply, with only a small proportion of patients receiving transplants. As a promising solution, minipigs have emerged as valuable models in xenotransplantation due to their physiological similarities to humans, yet the understanding of DNA elements with regulatory functions remains limited. This study provides the first comprehensive transcriptomic and epigenomic map of minipigs, analyzing five tissues (back fat, heart, kidney, liver, and loin) from groups at the ends of a continuum in body size variation. This foundational epigenomic dataset identified tissue-specific genes, revealing key mechanisms underlying physiological and pathological processes such as MYH7B in the heart and ITIH4 in the liver. Genes with differential epigenomic signatures according to the body size variation within minipigs included DES in the heart, which is involved in myofibril linkage and filament formation. Notably, human DNA methylation features in immune-associated genes such as IFI30, NCK2, NFKB1, and SOS2 exhibited stronger epigenomic conservation with minipigs than standard pigs, emphasizing their potential as a closer model for human immune responses. In conclusion, this high-resolution dataset provides a valuable foundation for advancing research in xenotransplantation, organ development, and immune mechanisms, positioning minipigs as a robust model for biomedical applications. - Source: PubMed
Publication date: 2025/07/07
Kim Seong JunKang DayeonJang SubinChai Han-HaKim JaeminPark Woncheoul - ACK1, a non-receptor tyrosine kinase, phosphorylates various substrates involved in cancer progression. Its oncogenic activity is driven by gene amplification, mutations, and post-translational modifications. However, additional regulatory mechanisms that govern ACK1 activity remain to be fully understood. Liquid-liquid phase separation (LLPS) has emerged as a key mechanism of cellular compartmentalization, controlling the spatiotemporal dynamics of signaling pathways. - Source: PubMed
Publication date: 2025/06/28
Liu AndongLu XiaSong YanyangPei JiayingWei Ruozheng - The role of structural variations (SVs) in Alzheimer's disease (AD) remains understudied. - Source: PubMed
Wang HuiDombroski Beth ACheng Po-LiangTucci AlbertSi Ya-QinFarrell John JTzeng Jung-YingLeung Yuk YeeMalamon John S Wang Li-SanVardarajan Badri NFarrer Lindsay ASchellenberg Gerard DLee Wan-Ping