Ask about this productRelated genes to: MKP4 antibody
- Gene:
- DUSP9 NIH gene
- Name:
- dual specificity phosphatase 9
- Previous symbol:
- -
- Synonyms:
- MKP-4, MKP4
- Chromosome:
- Xq28
- Locus Type:
- gene with protein product
- Date approved:
- 1998-06-25
- Date modifiied:
- 2015-09-11
Related products to: MKP4 antibody
Related articles to: MKP4 antibody
- This study investigated the mechanistic role of DUSP9 in hepatoblastoma (HB) development and progression to provide new insights into the diagnosis and treatment of pediatric HB. Pediatric HB mRNA expression data were obtained from the GEO database. Differentially expressed genes (DEGs) between patients with metastatic and non-metastatic HB were analyzed using the R software, followed by a functional annotation of the DEGs. Least Absolute Shrinkage and Selection Operator regression and Support Vector Machine-Recursive Feature Elimination machine learning methods were employed to further screen for DEGs and identify DUSP9 as a key feature gene. The diagnostic efficacy of DUSP9 was evaluated using the area under the receiver operating characteristic curve. Additionally, in vitro and in vivo functional experiments were conducted to determine the effects of DUSP9 on HB progression. A total of 33 DEGs were identified. Gene Ontology analysis revealed that these DEGs were mainly associated with xenobiotics and fatty acid metabolism. Kyoto Encyclopedia of Genes and Genomes analysis indicated involvement in regulating active transmembrane transporter activity and cytochrome P450-mediated xenobiotic metabolism. Machine learning methods identified DUSP9 as a pivotal feature gene that was significantly upregulated in HB tumor tissues. In vitro functional assays demonstrated that DUSP9 knockdown markedly inhibited the proliferation and migration of HB cells. Additionally, western blot analysis revealed increased expression of epithelial markers and decreased expression of mesenchymal markers, along with a significant reduction in the phosphorylation of markers related to the MAPK signaling pathway. DUSP9 plays a crucial role in HB cell proliferation, migration, and epithelial-mesenchymal transition (EMT), potentially promoting tumor progression by regulating the MAPK signaling pathway. - Source: PubMed
Publication date: 2026/08/10
Zhou PingpingWu XiongweiYang QvanxinWang ChaojinDuan YuheDong Qian - - Source: PubMed
Publication date: 2026/06/23
Zhang JingyangZheng QinLiu Mulin - Large-scale multiancestry genome-wide association studies have identified hundreds of loci associated with type 2 diabetes (T2D) and glycemic traits, yet imputed genotyping arrays limit the detection of low-frequency and rare variants. Whole-genome sequencing (WGS) offers a more complete view of genetic variation, especially across diverse populations. We analyzed high-coverage (38×) WGS data from 21,913 T2D case subjects, 61,036 control subjects, and up to 50,011 individuals with no diabetes with fasting glucose, fasting insulin, and HbA1c from the National Heart, Lung, and Blood Institute Trans-Omics for Precision Medicine Program. We performed single-variant association testing, conditional analysis, fine-mapping, and Bayesian colocalization to identify genetic signals and assess regulatory relevance in diabetes-related tissues. We identified 76 distinct association signals across 34 loci, including novel variants at DUSP9 for T2D, and ROBO1, NDN, and MYT1 for HbA1c. Fine-mapping narrowed credible sets and improved causal variant resolution. Colocalization highlighted 80 expression signals in diabetes-related tissues, linking genetic associations to functional regulatory mechanisms. Our findings demonstrate the utility of WGS to uncover novel variants in diverse populations, enhance locus resolution, and link regulatory variation to disease-relevant tissues. This work refines the genetic architecture of T2D and glycemic traits and supports precision medicine efforts targeting diverse populations. - Source: PubMed
Wang NingyuanDiCorpo Daniel AZhang YixinKleinbrink EricaArnett Donna KBarnard JohnBlangero JohnBowden Donald WCarson April PChen Yii-Der IdaChung Mina KCurran Joanne EDarbar DawoodDuggirala RavindranathEllinor Patrick TFatkin DianeFornage MyriamHeard-Costa NancyHe JiangHou LifangKardia Sharon L RKooperberg CharlesLoos Ruth J FMcManus David DMitchell Braxton DMinster Ryan LNorth Kari EPsaty Bruce MRaffield Laura MRedline SusanRich Stephen SRoden DanRotter Jerome IShoemaker Moore BSmith Jonathan DVan Wagoner David RAguet FrancoisArdlie KristinBis Joshua CBrody Jennifer ACade Brian EClish Clary Bde Vries Paul SFloyd James SFreedman Barry IGabriel StaceyGerzsten Robert EGoodarzi Mark OGu CharlesGuo XiuqingGupta NamrataHeckbert Susan RHsu SarahHung Yi-JenKalyani Rita RKelly Tanika NKinney Gregory LLi ChangweiLiu SiminLiu YongmeiLloyd-Jones Donald MManson JoAnn EMathias Rasika AMercader Josep MMorrison Alanna CNaseri TakeOnengut SunaPalmer Nicholette DPeyser Patricia AQi QibinRaghavan SridharanReiner Alex PRooney Mary RSevilla-Gonzalez MagdalenaSarnowski ChloeSmith Joshua DSmith Jennifer ASpartano Nicole LTahir UsmanTaylor Kent DTobias Deirdre KTracy Russel PViali Satupa'iteaWang HemingWood Alexis CYanek Lisa RZhao WeiZheng YinanDupuis JoséeLiu Ching-TiSladek RobertWessel JenniferMeigs James BManning Alisa K - Head and neck squamous cell carcinoma (HNSCC) exhibits heterogeneous responses to immunotherapy, primarily determined by the tumor immune microenvironment (TME). Accordingly, there is an urgent need for reliable biomarkers that can effectively distinguish between immune "hot" and "cold" tumors and predict prognosis and immunotherapy response. - Source: PubMed
Publication date: 2026/04/08
Li PianPang KelingZhou ZhigangYang ChaolinChen YiWu YangjieWang FujueHe Junyan - Transarterial chemoembolization (TACE) is the primary treatment for unresectable hepatocellular carcinoma (HCC). Given the poor prognosis of liver cancer patients with diabetes, identifying indicators of response to TACE and methods to reverse non-response is crucial. - Source: PubMed
Publication date: 2026/01/21
Wang WeitaoChen KangFan ChenSun LeiTang HaohuanDing WeiSun FeihuWang Weidong