Ask about this productRelated genes to: DUSP28 antibody
- Gene:
- DUSP28 NIH gene
- Name:
- dual specificity phosphatase 28
- Previous symbol:
- -
- Synonyms:
- VHP, DUSP26
- Chromosome:
- 2q37.3
- Locus Type:
- gene with protein product
- Date approved:
- 2007-01-04
- Date modifiied:
- 2016-10-05
Related products to: DUSP28 antibody
Related articles to: DUSP28 antibody
- - Source: PubMed
Publication date: 2023/12/02
Lee JungwhoiLee JungsulKim Jae-Hoon - Breast cancer (BCa) has been the most commonly diagnosed cancer worldwide and the leading cause of cancer-related death. Dual-specificity phosphatase 28 (DUSP28) is associated with various cancer progression, but its function and mechanism in breast cancer remain unclear. - Source: PubMed
Zhang JiaboGuo Yu - Gene expression and DNA methylation analyses have long been used to identify cancer markers. However, a combination analysis of the gene expression and DNA methylation has yet to be performed to identify potential biomarkers of hepatocellular carcinoma (HCC). - Source: PubMed
Publication date: 2022/01/17
Chen HuiZhang ChuntingZhou QianmeiGuo YananRen ZhigangYu Zujiang - Pancreatic cancer remains one of the most dangerous cancers with a grave prognosis. We have reported that dual specificity phosphatise 28 (DUSP28) could be secreted in pancreatic cancer cells. However, its biological function is poorly understood. Here, we distinguish the function of scattered DUSP28 in human pancreatic cancer. DUSP28 was specifically secreted to cultured medium in metastatic pancreatic cancer cells. Treatment with recombinant DUSP28 significantly increased the migration, invasion, and viability of metastatic pancreatic cancer cells through the activation of CREB, AKT, and ERK1/2 signaling pathways. In addition, administration of recombinant DUSP28 elicited pro-angiogenic effects in human umbilical vein endothelial cells. Injection of recombinant DUSP28 also produced tumor growth in vivo. Of interest, DUSP28 formed an autocrine loop with integrin α1 (ITGα1) by transcriptional regulation and recombinant DUSP28 acted as an oncogenic reagent through the interaction with ITGα1. Notably, scattered DUSP28 could be detected in whole blood samples of pancreatic cancer patients by accessible immunoassay. These results provide the basis for DUSP28 as a promising therapeutic target and a biomarker for metastatic pancreatic cancer. - Source: PubMed
Publication date: 2019/03/19
Lee JungwhoiLee JungsulKim Jae-Hoon - Dual-specificity phosphatases (DUSPs) constitute a subfamily of protein tyrosine phosphatases, and are intimately involved in the regulation of diverse parameters of cellular signaling and essential biological processes. DUSP28 is one of the DUSP subfamily members that is known to be implicated in the progression of hepatocellular and pancreatic cancers, and its biological functions and enzymatic characteristics are mostly unknown. Herein, we present the crystal structure of human DUSP28 determined to 2.1 Å resolution. DUSP28 adopts a typical DUSP fold, which is composed of a central β-sheet covered by α-helices on both sides and contains a well-ordered activation loop, as do other enzymatically active DUSP proteins. The catalytic pocket of DUSP28, however, appears hardly accessible to a substrate because of the presence of nonconserved bulky residues in the protein tyrosine phosphatase signature motif. Accordingly, DUSP28 showed an atypically low phosphatase activity in the biochemical assay, which was remarkably improved by mutations of two nonconserved residues in the activation loop. Overall, this work reports the structural and biochemical basis for understanding a putative oncological therapeutic target, DUSP28, and also provides a unique mechanism for the regulation of enzymatic activity in the DUSP subfamily proteins. - Source: PubMed
Publication date: 2017/11/09
Ku BonsuHong WonKeum Chae WonKim MyeongbinRyu HyunyeolJeon DonghwanShin Ho-ChulKim Jae HoonKim Seung JunRyu Seong Eon