Ask about this productRelated genes to: CREB5 antibody
- Gene:
- CREB5 NIH gene
- Name:
- cAMP responsive element binding protein 5
- Previous symbol:
- -
- Synonyms:
- H_GS165L15.1, CRE-BPA
- Chromosome:
- 7p15.1-p14.3
- Locus Type:
- gene with protein product
- Date approved:
- 2003-09-04
- Date modifiied:
- 2018-02-13
Related products to: CREB5 antibody
Related articles to: CREB5 antibody
- Acute myeloid leukemia (AML) is driven by complex interactions among genetic alterations, metabolic reprogramming, and immune microenvironment dysregulation. Ferroptosis, a form of iron-dependent regulated cell death linking iron metabolism with immune regulation, has been implicated in AML; however, its causal interplay with immune cells remains unclear. Therefore, this study employed a Mendelian randomization (MR) approach to systematically investigate this relationship. - Source: PubMed
Publication date: 2026/09/21
Meng QiZhou ZihaoZhang Wanchao - Ferroptosis, an iron-dependent, regulated form of cell death, has been increasingly recognised as a pivotal driver of organ dysfunction and mortality in sepsis. Despite its importance, the transcriptomic regulation of ferroptosis in human sepsis has not been systematically characterised. Here, we present a comprehensive integrative analysis, combining 17 transcriptomic data sets from previously published studies involving blood samples from septic patients and healthy controls, encompassing microarray, bulk RNA sequencing, and single-cell RNA sequencing platforms. Our findings reveal that ferroptosis-related gene regulation intensifies with disease progression and is markedly more pronounced in adults. Single-cell analysis identified monocytes as the primary regulators of ferroptosis in peripheral blood during sepsis. Eleven core ferroptosis-related genes (, , , , , , , , , , and ) were consistently upregulated, serving as robust candidates for sepsis biomarkers, while additional genes correlated with disease severity, suggesting prognostic value. This large-scale integrative approach provides novel molecular insights into sepsis pathophysiology and identifies promising targets for improved diagnosis and therapy. - Source: PubMed
Publication date: 2026/09/15
Sales Miguel Victor BringelNakaya Helder ImotoCunha Fernando de QueirozOliveira Antonio Edson Rocha - Kazakh horses are typical seasonal breeders, and ovarian activity is markedly reduced during the non-breeding period. Hormonal stimulation can induce ovarian functional responses during seasonal anestrus; however, the early ovarian transcriptional changes associated with this response remain incompletely understood. In this study, ovarian transcriptome sequencing was performed in 12 Kazakh mares examined during the seasonal anestrous period. The mares were classified into a non-hormonally stimulated seasonal quiescent group (DB, = 6) and a hormone-induced ovarian activation group (DY, = 6) following cloprostenol and eCG treatment. RNA sequencing and bioinformatics analyses were conducted to identify differentially expressed genes and enriched biological pathways. Using false-discovery-rate-corrected criteria (FDR < 0.05 and |log2FC| > 1), a total of 2119 differentially expressed mRNAs and 530 differentially expressed lncRNAs were identified between the two groups. FDR-corrected GO and KEGG enrichment analyses revealed significant changes associated with immune regulation, cellular communication, metabolic processes, and reproductive functions. KEGG pathway analysis demonstrated significant enrichment of complement and coagulation cascades, cytokine-cytokine receptor interaction, chemokine signaling pathway, PI3K-Akt signaling pathway, and ovarian steroidogenesis-related pathways (q ≤ 0.05). , , and were prioritized as transcriptomic candidate genes based on their differential expression and pathway associations, but their functional roles were not experimentally tested. RT-qPCR analysis of selected DEGs showed expression trends concordant with the RNA-seq results and was used as a technical consistency assessment. Because the DY group was pharmacologically induced during seasonal anestrus and tissues were collected shortly after ultrasound confirmation of ovarian activation, the observed transcriptional profile should be interpreted as an early hormone-responsive state rather than a stable estrous state. Furthermore, because untreated naturally cycling mares during the reproductive season were not included, endogenous seasonal effects cannot be distinguished from pharmacological effects of hormonal stimulation. - Source: PubMed
Publication date: 2026/09/07
Zhou YuheRen WanluZeng YaqiWang JianwenMeng JunYao XinkuiZhai Manjun - V2a interneurons are excitatory neurons found throughout the hindbrain and spinal cord, two regions that arise from distinct progenitors during embryonic development. Whether this lineage difference shapes mature gene regulation and function is unknown. V2a neurons show plasticity after spinal cord injury and are candidates for cell therapy. We differentiated human stem cells into V2a neurons through hindbrain- and spinal cord-like progenitor routes and profiled them by single nucleus multiomic sequencing. The two lineages showed distinct transcription factor motif enrichment and differentially expressed genes governing axon growth and calcium handling. Inducing V2a transcription factors directly, bypassing developmental patterning, produced a population unlike either lineage, confirming progenitor history is not interchangeable. Using CellOracle and lentiviral knockdown, we identified CREB5 and TCF7L2 as regulators specific to the spinal-like lineage. These results show that progenitor origin shapes V2a identity and reveal new regulators of neural diversity along the anterior-posterior axis. - Source: PubMed
Publication date: 2026/07/29
Elder Nicholas HMajd AlirezaCesiulis AndriusNyarady SpencerSankar KalyanBulger Emily ASamuel Ryan MZholudeva Lyandysha VMcDevitt Todd CFattahi Faranak - Pediatric septic shock is a severe form of sepsis with high mortality. Histone deacetylation is involved in sepsis-related disorders. This study investigated the diagnostic value of histone deacetylation-related genes in pediatric septic shock. Three Gene Expression Omnibus datasets (GSE26378, GSE26440, and GSE13904) were analyzed. Differentially expressed genes from GSE26378 and GSE26440 were intersected with genes in key modules identified by weighted gene co-expression network analysis. Least absolute shrinkage and selection operator regression and random forest were used to identify hub genes, and receiver operating characteristic curves assessed diagnostic performance. Quantitative real-time polymerase chain reaction validated candidate gene expression. Immunoprecipitation preliminarily evaluated protein acetylation changes after trichostatin A treatment. Immune infiltration was analyzed, and related transcription factors and miRNAs were predicted. C9orf84, ASAP1-IT1, and CREB5 were identified as hub genes. All were upregulated in pediatric septic shock and showed favorable diagnostic performance in the training and validation datasets. Trichostatin A increased the acetylation levels and reduced the protein levels of C9orf84 and CREB5. Neutrophils, macrophages, and regulatory T cells were more abundant in pediatric septic shock than in controls. Multiple potentially interacting transcription factors and miRNAs were also identified. C9orf84, ASAP1-IT1, and CREB5 may serve as diagnostic biomarkers and therapeutic targets for pediatric septic shock. - Source: PubMed
Publication date: 2026/07/20
Yao JiLai ZhongbinYu DiXia JingzhaoHuang QunHe Shaoyi