Ask about this productRelated genes to: RARB antibody
- Gene:
- RARB NIH gene
- Name:
- retinoic acid receptor beta
- Previous symbol:
- -
- Synonyms:
- HAP, NR1B2, RRB2
- Chromosome:
- 3p24.2
- Locus Type:
- gene with protein product
- Date approved:
- 1989-05-16
- Date modifiied:
- 2017-07-07
Related products to: RARB antibody
Related articles to: RARB antibody
- To assess the association of RET, NRG1, SEMA3, and RARB gene variants with clinical phenotypes of Hirschsprung disease (HSCR) in a population with limited genetic data (Aceh, Indonesia). - Source: PubMed
Publication date: 2026/05/08
Isa Muntadhar MSyukri MaimunMuchlisin Z AGunadi Syahputra Dian AdiYusriadi TeukuMuzakkir YumnaKamarlis Reno KeumalaziaEffendy ZulhamSetyadi AhmadMaghfirah SitiRinanda Tristia - DNA methylation alterations represent a key epigenetic mechanism linking environmental exposures to disease pathogenesis. The present study aimed to identify differentially methylated genes and shared biological processes associated with lung cancer (LuCa), chronic obstructive pulmonary disease (COPD) and tobacco exposure. A comprehensive literature search was performed in PubMed to identify studies evaluating DNA methylation in LuCa, COPD and smoking-related models. A total of 117 articles were selected, including 83 studies on lung cancer, 18 on COPD and 16 on smoking exposure. Genes exhibiting statistically significant methylation changes relative to controls were extracted from each study. To provide additional support for these findings, differential methylation signatures were further evaluated using The Cancer Genome Atlas (TCGA) lung adenocarcinoma (LUAD) and lung squamous cell carcinoma (LUSC) datasets. Functional and transcription factor motif enrichment analyses were subsequently conducted to identify shared biological pathways and regulatory mechanisms. In total, 324 genes displaying altered methylation patterns across these conditions were identified. Seven tumor suppressor genes (, , , , , , and ) consistently exhibited hypermethylation in both lung cancer and in association with smoking exposure. In addition, hypomethylation emerged as a shared epigenetic hallmark across all three conditions. TCGA-based analyses confirmed several of these methylation patterns and revealed subtype-specific methylation profiles associated with smoking history. Functional enrichment highlighted common biological processes and signaling pathways, particularly those related to transcriptional regulation, apoptosis and cancer-associated pathways. These results provide an integrative overview of shared DNA methylation alterations associated with smoking exposure, COPD, and lung cancer, and suggest potential DNA methylation candidates that may be relevant for future biomarker development and mechanistic studies. - Source: PubMed
Publication date: 2026/04/17
Forigua Camila BernalBermúdez Litzy GisellaCañas Arboleda AlejandraAriza Rafael RRoldán Maria TeresaMorales Maria TeresaGonzález Cubides Daniel MauricioRojas Adriana - Although exercise is the most effective strategy for increasing the skeletal muscle mass, the underlying molecular mechanisms remain poorly understood. We previously demonstrated that β-carotene, a provitamin A compound, enhances muscle mass through a retinoic acid receptor γ (RARγ)-dependent pathway. However, the involvement of vitamin A in exercise-induced muscle hypertrophy remains unclear. In this study, we used a mouse model of functional overload to mimic resistance exercise and investigated the role of vitamin A in overload-induced muscle growth. Overload increased the expression of Rdh10, Dhrs9 and Aldh1a2, an enzyme required for active vitamin A synthesis in the skeletal muscle. In contrast, the expression of Aldh1a1, Dhrs3, and Rarb was decreased by the overload. Vitamin A deficiency significantly suppressed overload-induced muscle hypertrophy and protein synthesis. Moreover, local administration of an RAR antagonist to the skeletal muscle reduced overload-induced protein synthesis. These findings suggest that vitamin A contributes to skeletal muscle hypertrophy during muscle overload by promoting protein synthesis via RAR-mediated signaling. - Source: PubMed
Kitakaze TomoyaNakatsuji AinoHarada NaokiYamaji Ryoichi - Here we describe unrelated Japanese patients with distinct novel heterozygous retinoic acid receptor beta (RARB) gene variants underlying syndromic microphthalmia-12: case 1 with a frameshift variant, c.1205_1206del, had bilateral microphthalmia, corneal opacity, anterior segment dysgenesis, widespread multiorgan anomalies, hypotonia and cognitive impairment; case 2 with a missense variant, c.844G>T had Peters anomaly, extreme microphthalmia, spasticity, profound psychomotor delay and refractory epilepsy. These findings highlight the need for RARB testing. - Source: PubMed
Publication date: 2026/04/06
Koyanagi YoshitoMorikawa-Anzai HazukiYoshida TomoyoTominaga MakikoAbe YuichiKosaki RikaMatsubara KeikoFukami MakiNishina Sachiko - Clutch length is a key determinant of reproductive efficiency in geese and strongly positively correlates with egg production. We recorded daily egg production in 280 individually housed Zi geese, calculated clutch-related indices, and selected 12 geese to form long-clutch (LC) and short-clutch (SC) groups for ovarian transcriptomic, proteomic, and metabolomic analyses. The results showed that egg number, large clutch length, large clutch number, average clutch length, and average clutch number were significantly higher in LC than in SC groups (P < 0.0001). Transcriptomic analysis identified 885 differentially expressed genes enriched in oocyte development and ovarian steroidogenesis, with APOB, PLA2G4C, MMP2, MMP9, and NOBOX as key genes; proteomic analysis identified 437 differentially abundant proteins enriched in arachidonic acid metabolism and mitophagy, with CXCL12, RARB, and MAD2L1 as key proteins; and metabolomic analysis identified 35 differentially abundant metabolites enriched in glycolysis/gluconeogenesis, with lactic acid, guanidinoacetic acid, and 3-hydroxybutyrylcarnitine as key metabolites. Integration of multi-omics datasets highlighted a lactate-associated cross-omics signature supported by YWHAZ at the protein level and by the lactate transporter SLC16A3. Collectively, these findings deepen our understanding of the molecular basis underlying clutch-length variation in goose ovaries and highlight candidate genes, proteins, and metabolites for future functional validation. - Source: PubMed
Publication date: 2026/03/02
Wang HechuanLiu YunuoJiang KeYin JiaxinCong KexinMiao XinyiYang WeiranZhang YingLiu Shengjun