Ask about this productRelated genes to: AKT3 antibody
- Gene:
- AKT3 NIH gene
- Name:
- AKT serine/threonine kinase 3
- Previous symbol:
- -
- Synonyms:
- PKBG, RAC-gamma, PRKBG
- Chromosome:
- 1q43-q44
- Locus Type:
- gene with protein product
- Date approved:
- 1999-11-16
- Date modifiied:
- 2018-02-13
Related products to: AKT3 antibody
Related articles to: AKT3 antibody
- Metabolic reprogramming is a hallmark of hepatocellular carcinoma (HCC), and amino acid reprogramming plays an important role in its metastatic progression. However, the function of amino acid reprogramming in HCC metastatic progression remains unclear. This study aimed to elucidate the function and mechanism of amino acid reprogramming, particularly focusing on proline metabolism, in driving HCC metastasis. HCC cohort and multiple HCC models were enrolled to investigate the role of amino acid reprogramming in HCC metastatic progression. The pro-metastatic effect of l-proline in HCC was consistently validated across in vitro and in vivo studies. Ribosome profiling (Ribo-seq) and l-proline pull-down were used to investigate the mechanism of proline-mediated HCC metastasis. Based on metabolomics and proteomics, we found that proline metabolism was enhanced during HCC metastasis, as evidenced by increased proline levels and proline metabolism-related enzymes in both HCC metastatic patients and mice. Moreover, high levels of proline were found to promote HCC metastasis. Mechanistically, l-proline directly interacted with glutamyl-prolyl-tRNA synthetase 1 (EPRS1) at its Glu residue, thereby selectively enhancing the translation of phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit α (PIK3CA), AKT serine/threonine kinase 3 (AKT3), and integrin subunit β1 (ITGB1). Importantly, the enhanced protein translation could be abolished by bersiporocin, an EPRS1 inhibitor that prevents l-proline binding to EPRS1. Finally, the inhibitory effect of bersiporocin on HCC metastasis was confirmed in patient-derived orthotopic xenograft models. Our findings not only revealed the critical role of l-proline-bound EPRS1 in promoting HCC metastasis but also indicated that inhibiting this binding could be a promising strategy to prevent metastasis. - Source: PubMed
Publication date: 2026/05/14
Zhang HuiGu LeirongSu XiamengChen WanjinTan MingYu HaiboZhou HongzhongGao TingtingWang ZhilingChen XinyanChen WeixianChen JuanCheng Shengtao - This study aims to explore the regulatory effect of miR-511-3p expression imbalance on the AKT3/USP8 signaling pathway, as well as the "molecular bridge" function of this signaling imbalance between neuroinflammation and post-stroke cognitive impairment (PSCI). - Source: PubMed
Publication date: 2026/04/28
Zhao WeiSong KangpingYang FenXiao HuiLiu YanYu YachunWang Te - Acute lung injury (ALI) is a severe, life-threatening inflammatory condition, characterized by uncontrolled neutrophilic inflammation and tissue damage. That emphasized the urgent need for innovative pharmacologic therapies. The aim of this study was to investigate the effects of Celastrol, a major bioactive compound extracted from the Thunder of God Vine, and the underlying mechanisms of its impact on ALI. - Source: PubMed
Publication date: 2026/05/08
Zhang YuYang YunLin ZhifengChen RikenQiang XinhuaLi ChangGuo WeiguangCao JunYe YinongZhou Lixin - Cuproptosis, a newly discovered form of copper-driven regulated cell death, has been shown to be closely related to ovarian function. However, whether the oocyte dysfunction, decreased ovulation efficiency, and cumulus cell aging caused by copper overload or imbalance are associated with regulatory pathways related to cuproptosis remains unclear. In this study, the expression profiles of genes related to cuproptosis in cumulus cells were comprehensively analyzed through transcriptome sequencing and metabolome analysis, and key genes and pathways that affect oocyte maturation were identified in response to elesclomol and CuSO treatment. Transcriptome analysis of cumulus cells revealed the differential expression of genes involved in key biological processes, such as cellular senescence (AKT3, MORC3, RBL1, etc.), gap junctions (GJA1, GNAI1, GJB3, etc.), steroid biosynthesis (FDX1, HSD17B7, CYP1A1, etc.), and cell cycle regulation (CDK2, CCNB2, MAPK7, etc.). Metabolomic analysis revealed significant changes in the levels of malic acid, PS (18:3(10,12,15)-OH(9)/14:0), and PA (21:0/LTE4), among other compounds. Subsequent Smart-seq analysis of oocytes revealed that after cuproptosis was induced in cumulus cells, oocyte maturation was disrupted, which affected genes associated with cellular senescence (TGFB2, SIRT1, CHEK2, etc.), oocyte meiosis (FBXO5, CCNB3, PLK1, etc.), and DNA methylation (PPM1D, DNMT3B, KMT2A, etc.). These findings provide deeper theoretical support for the key genes and biological processes involved in cumulus cell regulation and oocyte maturation, further clarifying the regulatory mechanisms of cuproptosis in the field of reproduction. - Source: PubMed
Publication date: 2026/05/05
Xu HongTian TianXu DanDu XiaoxueSu RuiLiang JinghongLiu YingZhang YuqingLiu ChangLiang ShuangLi QingyingDing DeliHan YongshengZhai BoLi JidongChen ChengzhenZhang JiabaoJiang HaoYuan Bao - Epidemiological studies show an inverse association between cigarette smoking and Parkinson's disease (PD), suggesting a potential protective effect of smoking on PD incidence, despite the well-established and overwhelming harms of smoking to human health. We integrated genomic and proteomic approaches to investigate the causality and molecular basis of this potential relationship. - Source: PubMed
Publication date: 2026/04/20
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