Ask about this productRelated genes to: DNMT3b antibody
- Gene:
- DNMT3B NIH gene
- Name:
- DNA methyltransferase 3 beta
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 20q11.21
- Locus Type:
- gene with protein product
- Date approved:
- 1998-07-15
- Date modifiied:
- 2019-04-23
Related products to: DNMT3b antibody
Related articles to: DNMT3b antibody
- - Source: PubMed
Publication date: 2026/04/23
Rizvi AshimaKansal RadhikaDatta Malabika - - Source: PubMed
Publication date: 2026/03/10
Chen XinJingHong Jingxuan - Distinguishing intrapulmonary metastasis (IPM) from separate primary lung cancers (SPLC) is crucial for staging and management of multiple lung cancers (MLC). Current methods lack a gold standard, limiting precise diagnosis to a subset of patients. This study introduces DNA methylation biomarkers to differentiate IPM from SPLC. - Source: PubMed
Publication date: 2026/04/15
Xu KeTan BinghuaLiang RuihaoLiang JialuHe ZhanghaiHe JianqunZhong YimingHu XuetingLei KaiLu HanlinZhang JuyongLin HuayueWang Minghui - Seasonal breeders rely on light as a key environmental cue to trigger reproductive activities. While studies have been focused on male white-rumped munia (), the effects on females are largely unknown. This study examined how light compositions affect female reproductive physiology. In the first experiment, female birds were exposed to short day (SD; 8 L:16D) and long day (LD; 15 L:9D) for a single day to study various transcripts involved in seasonal reproduction. The second experiment included SD and LD along with an added photoperiod of 12 L:12D, and the treatment extended for 30 d. In the third experiment, female birds were exposed to the above three photoperiod conditions, including natural day length (NDL), to assess morphological changes across 18 months. The fourth experiment evaluated seasonal variations in reproductive parameters across four months: March, June, September, and December. The fifth focused on illuminance levels (10, 50, and 100 lux) under a photoperiod of 12 L:12D, and the sixth assessed responses to red (650 nm) and blue light (450 nm) at a constant irradiance of 0.5 W/m. In all six experiments, an assessment of body mass and follicular diameter was done, while Experiment 3 specifically examined full-body moult and primary flight feather moult as well. Hypothalamic tissue was analysed for reproductive and epigenetic markers. The first experiment revealed enhanced expression of and in the long-day group, while no significant changes in other reproductive ( and ) and epigenetic ( and ) transcripts were observed. The second experiment observed increased expression of exclusively under 15 L:9D, while and transcripts were increased under 12 L:12D. Experiment 3 demonstrated distinct morphological responses to different photoperiods, with significant increases in follicular diameter under 15 L:9D and NDL conditions at the 7 month, but this effect was delayed until the 10 month under 12 L:12D. In contrast, no change was observed under 8 L:16D. Seasonal variations in transcripts were noted, with the highest expression of , and in September compared to other months. The fifth experiment showed that exposure to 100 lux increased key reproductive markers (, and ) and epigenetic regulators ( and ), while the sixth experiment found no significant differences between red and blue light treatment. Overall, the findings highlight the importance of light duration and illuminance in reproductive responses. While no robust change in epigenetic transcript was observed under laboratory conditions in female birds, the epigenetic changes observed in the seasonal experiment suggest that seasonal reproductive cycles are under regulation of epigenetic mechanisms at the molecular level. - Source: PubMed
Publication date: 2026/04/14
Lalpekhlui RuthHnamler LalsiamkimaTrivedi Amit Kumar - Amomum tsao-ko, a valued traditional medicinal and culinary plant, lacks a systematic characterization of its primary nutritional metabolites across different varieties and processing methods. This study employed widely-targeted metabolomics (UPLC-MS/MS) combined with transcriptome sequencing to comprehensively profile amino acids, vitamins, carbohydrates, and lipids in fresh and dried fruits of three morphologically distinct A. tsao-ko accessions. We identified 474 nutritional metabolites, uncovering significant varietal specificity; the round-fruited accession consistently accumulated higher relative levels of amino acids and vitamins. The drying process profoundly altered the nutritional composition, notably increasing carbohydrates and specific lipids. Integrated network pharmacology and molecular docking analyses pinpointed S-adenosylmethionine (SAM) as a key metabolite with high binding affinity to immunity-related targets (EZH2, DNMT1, DNMT3B). Furthermore, multi-omics correlation revealed that the differential accumulation of SAM among accessions is likely regulated by the transcriptional divergence of key genes (ACS1, ACO) in the ethylene biosynthesis pathway, suggesting a metabolic flux diversion mechanism. Our work provides a comprehensive nutritional baseline for A. tsao-ko, elucidates the impact of processing, and identifies a transcriptionally regulated, immunomodulatory metabolite, offering a scientific foundation for its tailored use in functional foods and nutraceuticals. - Source: PubMed
Publication date: 2026/03/17
Fu HongboXiong LinaMa MengliLu Bingyue