Ask about this productRelated genes to: TEM8 antibody
- Gene:
- ANTXR1 NIH gene
- Name:
- ANTXR cell adhesion molecule 1
- Previous symbol:
- -
- Synonyms:
- TEM8, FLJ21776, FLJ10601, ATR
- Chromosome:
- 2p13.3
- Locus Type:
- gene with protein product
- Date approved:
- 2003-08-27
- Date modifiied:
- 2018-05-10
Related products to: TEM8 antibody
Related articles to: TEM8 antibody
- The TEM8 receptor (coded by ANTXR1) plays several roles in oncogenesis and novel oncolytic therapies, such as the SVV-01 virus, uniquely bind this protein in neuroendocrine tumor (NET) histologies, such as small-cell lung cancer (SCLC). Emerging pre-clinical data suggest that TEM8-targeting therapies may convert immunologically "cold" tumor microenvironments (TME) into "hot" milieu with greater responses to immune checkpoint inhibitors (ICIs). - Source: PubMed
Publication date: 2026/03/22
Kareff Samuel AKrause HarrisElliott AndrewSamec TimothyLopes GilbertoHosein Peter JJani Chinmay TLou EmilSoares HeloisaMagistri MarcoSumarriva DanielOberley MatthewChauhan Aman - - Source: PubMed
Publication date: 2026/04/16
Chen DengyunLin LipingWu YiboHuang KunboZhang HanhuiChen Qingqing - Inherited blood disorders (IBDs) are a major health concern in the Kingdom of Saudi Arabia (KSA), largely due to the high prevalence of consanguineous marriages. - Source: PubMed
Publication date: 2026/04/01
Younis Nancy SAlkabsh Rahma MNasser Alqahtani Shahad MAljuail HajerAlhashim Manar ABokhamsin Shahad AAlbaqshi Layla JAlqadhib Salsabil FAldandan Jumanah AAlshakhs Zahra AAltaweel Maryam HMohamed Maged E - Since 2014, Senecavirus A (SVA) has caused recurrent vesicular disease outbreaks in pigs and continues to circulate widely. However, functional evidence is limited as to whether mutations accumulated during long-distance spread alter receptor engagement or antigenicity, constraining sequence-based risk prioritization. We analyzed 263 quality-controlled, coding-complete SVA genomes after removing recombinant signals and integrated time-scaled phylogenetics with structural mapping and reverse genetics. Root-to-tip regression supported temporal signal. In time-scaled inference, the root location was assigned the highest posterior probability to the United States among sampled locations, and BSSVS supported inter-country connectivity links. Markov jump summaries, conditional on posterior ancestral-state reconstructions, were consistent with international transitions beginning around 2006. SkyGrid reconstruction suggested an increase in effective population size from about 2010-2020, while estimates near the ends of the time series may be sensitive to uneven sampling. Site-level analyses identified candidate selection signals mainly in capsid proteins and the RNA-dependent RNA polymerase, and structural mapping highlighted VP1 residues 62, 63, 93, and 97 near the ANTXR1 receptor-binding interface. We generated V93A, D97G, and double-mutant viruses and assessed replication, ANTXR1 binding, and cross-neutralization. Mutants displayed reduced replication in IB-RS-2 cells and porcine intestinal organoids, weaker ANTXR1 binding, and altered neutralization profiles relative to the parental strain. These results demonstrate that global SVA diversification is consistent with repeated connectivity and substantial drift under heterogeneous surveillance, while VP1 positions 93 and 97 exert clear biological effects and merit surveillance and antigenic follow-up. - Source: PubMed
Publication date: 2026/03/20
Yang JingZhang ZhiliangSha WeijiaPeng MingyueLi YizeGe XiaoyuLi JiaxuanCui WenJiang YanpingWang XiaonaTang Lijie - Background and ObjectivesTumor Endothelial Marker 8 (TEM8) is integral to angiogenesis, tumor microenvironment remodeling, and cancer cell proliferation, and its expression is upregulated in a variety of malignancies. Despite its potential as both a prognostic biomarker and a therapeutic target in triple-negative breast cancer (TNBC), the exact role of TEM8 in TNBC remains poorly understood. This study seeks to examine the expression of TEM8 protein in TNBC and explore its associations with clinicopathological characteristics and patient survival outcomes.MethodsClinical and pathological data from 118 patients diagnosed with TNBC via surgical pathology between January 2015 and December 2017 were retrospectively analyzed at Harbin Medical University Cancer Hospital. A total of 35 adjacent non-cancerous tissue samples were randomly selected from the tumor tissue samples of the 118 TNBC patients. Immunohistochemistry (IHC) was employed to assess the expression levels of TEM8 and CD31 proteins. The correlations between TEM8 expression and various clinicopathological features, as well as survival status, were analyzed.ResultThe positive expression rate of TEM8 in TNBC tumor tissues was 89.8% (106/118), significantly higher than 60% (21/35) observed in adjacent non-tumorous tissues (χ = 17.029, < .01). TEM8 expression was significantly correlated with microvessel density (MVD), axillary lymph node status, and TNM staging. Moreover, patients with high TEM8 expression levels exhibited significantly lower overall survival (OS) rates compared to those with low TEM8 expression. Multivariate analysis revealed that TEM8 expression and tumor size were independent prognostic factors for OS.ConclusionsTEM8 is highly expressed in TNBC tissues and is closely associated with angiogenesis, tumor proliferation, lymph node metastasis, and poor prognosis. TEM8 may serve as a potential prognostic marker, offering new insights for the diagnosis and therapeutic strategies in TNBC. - Source: PubMed
Publication date: 2026/01/08
Huang FurongLiu YangRen HongQiu HuiLeiJiang Yongdong