Ask about this productRelated genes to: LRG1 protein
- Gene:
- LRG1 NIH gene
- Name:
- leucine rich alpha-2-glycoprotein 1
- Previous symbol:
- -
- Synonyms:
- LRG
- Chromosome:
- 19p13.3
- Locus Type:
- gene with protein product
- Date approved:
- 2004-02-12
- Date modifiied:
- 2016-06-06
Related products to: LRG1 protein
Related articles to: LRG1 protein
- Cachexia in liver cirrhosis (LC) and hepatocellular carcinoma (HCC) is associated with poor outcomes. Although C-reactive protein (CRP) is used for diagnosis, its limited specificity may hinder detection of cachexia without systemic inflammation. Leucine-rich α2-glycoprotein 1 (LRG1) may identify cachexia when CRP is low; however, its significance in LC and HCC remains unclear. - Source: PubMed
Publication date: 2026/09/11
Tanaka TakatsuguSuda GokiOhara MasatsuguMaehara OsamuYoda TomokaFu QingjieYang ZijianYokoyama DaisukeYasuura NaohiroMeno AkimitsuKohya RisakoKitagataya TakashiKawagishi NaokiNakai MasatoSho TakuyaOhnishi ShunsukeSakamoto Naoya - Koalas are a vulnerable marsupial species with unique reproductive traits. Efforts to develop assisted breeding technologies have been hindered by a limited understanding of maternal recognition of pregnancy and physiological changes induced by the foeto-placental unit. Differences in the reproductive physiology of pregnant and non-pregnant koalas were examined to investigate the possibility of maternal recognition and identify potential pregnancy and/or embryonic loss biomarkers. - Source: PubMed
Publication date: 2026/08/06
Hartley Brooke EJohnston Stephen DCampbell YolandeFanson KerryNicolson VereNeal AshleighPini Taylor - This prospective study was designed to investigate the independent predictive values of () infection and tissue supernatant leucine-rich α-2-glycoprotein 1 (LRG1) levels for recurrence following endoscopic mucosal resection (EMR) of colonic polyps, and to construct a nomogram risk prediction model. - Source: PubMed
Publication date: 2026/08/17
Yu YinhongLu DongdongYe Fangxu - Effective, minimally invasive biomarkers are needed to predict treatment outcomes in ulcerative colitis (UC). This multicenter observational study investigated predictive serum and genetic biomarkers for vedolizumab (VDZ) therapy in UC, including serum leucine-rich α-2-glycoprotein (LRG), cytokines, and differentially expressed genes (DEGs) in intestinal tissue. - Source: PubMed
Publication date: 2026/08/11
Yoshihara TakeoShinzaki ShinichiroNaka TetsujiIijima HidekiHayashi Yoshito Ishiguro KaoriBaba YujiTakehara Tetsuo - Pancreatic cancer (PC) is a malignant tumor that often presents no obvious symptoms in its early stages, leading to late diagnosis and poor prognosis. Therefore, developing molecular markers for PC is essential for improving early diagnosis, optimizing treatment strategies, and enhancing patient outcomes. In this study, PC tissue and matched adjacent non-cancerous tissue were collected from patients. For in vitro analysis, the PC cell lines BxPC-3 and SW1990 were used. M2 macrophages were induced in THP-1 cells. Gene expression at both mRNA and protein levels was measured using real-time quantitative PCR and Western blotting. Cell counting kit-8 assay was used to evaluate cell activity. Flow cytometry was used to assess the cell apoptosis rate and M2 macrophage biomarkers. Transwell and wound-healing assays were used to determine cell migration and invasiveness. Co-immunoprecipitation assay was used to evaluate the binding relationship between leucine-rich α-2 glycoprotein 1 (LRG1), chemokine receptor 1 (CCR1), and GALNT6. LRG1 expression was upregulated in PC tissues compared to that in normal tissues. Co-culture with M2 macrophages enhanced gemcitabine (GEM) resistance, cell migration, and PC cell invasion. LRG1 overexpression in PC cells enhanced the effect of M2 macrophage cells to exacerbate GEM resistance, cell migration, and invasion, while LRG1 knockdown exhibited an opposite effect. LRG1 interacted with CCR1 to enhance PI3K/AKT signaling, thereby affecting GEM resistance, migration, and PC cell invasion. Moreover, GALNT6 was confirmed as an upstream regulator of LRG1, which glycosylated LRG1 and increased its stability. Rescue experiments demonstrated that GALNT6 promoted GEM resistance, movement, and invasion abilities of PC cells by regulating LRG1. The role of LRG1 in the interaction between PC cells and M2 macrophages was also verified in the xenograft model. These findings demonstrate that GALNT6-glycosylated LRG1 mediates the interaction between M2 macrophages and PC cells by activating CCR1. This study may provide promising therapeutic targets for PC treatment. - Source: PubMed
Publication date: 2026/08/08
Hong DengjianSu HangSu YexiongCai Duxiong