Ask about this productRelated genes to: DGKA antibody
- Gene:
- DGKA NIH gene
- Name:
- diacylglycerol kinase alpha
- Previous symbol:
- DAGK, DAGK1
- Synonyms:
- DGK-alpha
- Chromosome:
- 12q13.2
- Locus Type:
- gene with protein product
- Date approved:
- 1991-08-21
- Date modifiied:
- 2016-10-05
Related products to: DGKA antibody
Related articles to: DGKA antibody
- Metabolism is critical for immune cell functions. Tumours shape their microenvironment to render it metabolically hostile for infiltrating immune cells. While targeting immunometabolism emerges as a promising way to reinvigorate anticancer immunity, a deeper understanding of the metabolic disturbances of immune cells is needed. Here, we explored how the metabolic status of T cells governs immune skewing from circulating and tumour-infiltrating CD4 and CD8 T cells of melanoma patients at a single-cell level using the SCENITH method and targeted metabolomics. Circulating and tumour-infiltrating T cells from patients displayed a decreased mitochondrial dependency associated with an enhanced glycolytic capacity and a skewed metabolic reprogramming upon stimulation. Such metabolic disturbances were linked to the activation status, immune checkpoint profile and functional orientation of T cells, underlining critical connections between T-cell features and metabolic patterns. Targeted metabolomics within sorted CD4/CD8 T cells identified a decrease in citrulline, cysteine and threonine within all subsets in patients, together with a sharp rise in sterol cholesterol CE(20:2) and ceramide dhCer(d18:0/22:0) within tumour-infiltrating CD4 T cells, and in glycerolipid DG(16:0/16:0) within CD8 T cells in blood and tumour. We further outlined a metabolic-checkpoint-based signature composed of six genes coding enzymes/transporters connected to the imbalanced metabolites found within tumour-infiltrating T cells (LIPA, DGKA, GLUL, SLC38A1, SLC7A7, GCH1) that shape patients' clinical outcome. These findings outline the skewed bioenergetic profiles of T cells and depict metabolic checkpoints associated with immune subversion. Harnessing metabolic pathways is promising for developing innovative therapies to restore optimal anti-tumour responses and improve clinical success. - Source: PubMed
Publication date: 2026/08/04
Brouque HugoMahdy KareemMouret StephaneHenry SylvainNiveau CamilleCettour-Cave MélaniePelosse Martinde Fraipont FlorenceCharles JulieTurtoi AndreiSaas PhilippeAspord Caroline - Depressive disorders are a leading cause of global disability, yet gene expression studies in Middle Eastern populations remain scarce. This study investigated peripheral blood expression of seven candidate genes, previously identified in animal models and early-onset depression, in adults with and without depressive disorders in United Arab Emirates (UAE). - Source: PubMed
Publication date: 2026/07/01
Nawaz RukhsanaAl Awadhi EmanAl Mughairbi FadwaBashir AsmaAndrade GabrielBokhari Syed AliJavaid Syed FahadHamid Abdalla A R M - This study aimed to characterize the genomic features and possible transmission mechanisms of an extensively drug-resistant (XDR) Klebsiella pneumoniae (KP2024). The isolate was recovered from pelvic effusion of a postoperative colon cancer patient in Hebei, China, with a focus on the rare mcr-3.11 gene as well as blaNDM-5 and blaCTX-M-27. - Source: PubMed
Publication date: 2026/05/21
Zhao KaixuanWang WeiMa MingFeng JunhuaQi TianyuWang JiajieHe Jing - Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by synovial inflammation and joint destruction. Abnormal T-cell ubiquitination has been implicated in RA pathogenesis, yet its molecular mechanisms remain unclear. - Source: PubMed
Publication date: 2026/03/02
He DantingZhao HaitaoMeng Jinghong - Our previous work revealed that the anti-diarrhea effects of alkaline mineral complex (AMC) water improve metabolism and protect the gut during weaning stress. However, whether AMC water can inhibit viral replication and treat viral diarrhea is unknown. The aim of this study was to explore the ability of AMC water to improve nutrient metabolism and protect against infection. In this study, porcine epidemic diarrhea virus (PEDV) or porcine deltacoronavirus (PDCoV) were used as RNA model viruses, and pseudorabies virus (PRV) or porcine circovirus (PCV) were used as DNA model viruses. Compared with those in the infected group, the virus content in the piglets fed AMC water was reduced, and the intestinal mucosal barrier was repaired. Transcriptome and metabolome results revealed that AMC water regulated lipid metabolism through GPAT2, DGKA, OAT3, FXR, LIPC and SULT2A1. Further studies showed that glycerol, cholesterol, and bilirubin levels increased after viral infection, and that AMC water inhibited cholesterol content and promoted bile acid synthesis. In a cellular model, AMC water reduced lipid droplet density by activating the glycerolipid and bile secretion pathways of the GPAT2/SULT2A1 axis. In addition, knockdown of DGKA and overexpression of SULT2A1 significantly affected the expression of the GPAT2/SULT2A1 axis, and the expression of viral proteins colocalized with lipid droplets was significantly decreased. Our findings suggest that AMC water promotes cholesterol metabolism by activating the GPAT2/SULT2A1 axis, inhibiting viral infection in piglets. This study provides theoretical support for the use of nutritional regulation to inhibit viral infection and provides a new method for antiviral therapy. - Source: PubMed
Publication date: 2026/03/11
Yao XinLi Nuo-WaLiu Ying-YingMalhi Kanwar KumarZhang Tian-TianZhao YangLi Hui-XinLi Jin-Long