Ask about this productRelated genes to: CD51 antibody
- Gene:
- ITGAV NIH gene
- Name:
- integrin subunit alpha V
- Previous symbol:
- VNRA, MSK8, VTNR
- Synonyms:
- CD51
- Chromosome:
- 2q32.1
- Locus Type:
- gene with protein product
- Date approved:
- 1988-07-19
- Date modifiied:
- 2016-10-05
Related products to: CD51 antibody
Related articles to: CD51 antibody
- Embryo implantation is a critical and tightly regulated process essential for successful human reproduction. Although the role of endometrial receptivity is well established, the molecular mechanisms governing this process are not thoroughly understood. Circadian rhythm regulators, particularly brain and muscle aryl hydrocarbon receptor nuclear translocator-like protein 1 (BMAL1), have emerged as key modulators in reproductive biology. In this study, we investigated the role of BMAL1 in regulating endometrial receptivity and embryo implantation. Ishikawa cells were transfected with BMAL1-specific or control siRNA, followed by RT-qPCR, western blotting, and immunofluorescence analyses. Functional assays, including migration assays, co-culture with JEG-3 spheroids, cell viability, and cytotoxicity, were also performed. Our results demonstrated that BMAL1-knockdown in Ishikawa cells downregulated adhesion-related genes, including ITGAV, ITGB3, and ITGB5. Although total ITGB5 protein levels remained stable, its localized expression intensity was significantly reduced; the protein expression of ITGAV and ITGB3 was decreased, and cell migration was impaired. Notably, while BMAL1-knockdown compromised cellular motility, it had no significant effect on cell viability or cytotoxicity. A co-culture model with JEG-3 spheroids further demonstrated significantly decreased embryo adhesion following BMAL1-knockdown. In conclusion, BMAL1 is a critical regulator of integrin-mediated adhesion and endometrial receptivity, underscoring its potential as a therapeutic target for recurrent implantation failure. - Source: PubMed
Publication date: 2026/06/16
Imai KeitaDai YidanOno MasanoriImai YoshinariKojima JunyaFujiwara TomokoDaikoku TakikoMaida YoshikoAndo HitoshiFujiwara HiroshiNishi Hirotaka - Nasopharyngeal carcinoma (NPC) is a malignant epithelial tumor strongly associated with Epstein-Barr virus (EBV) infection. EBV-mediated dysregulation of host microRNAs (miRNAs) contributes to NPC pathogenesis, but the functions of many EBV-regulated host miRNAs remain incompletely defined. miR-10b-3p is markedly downregulated in EBV-positive NPC, yet its biological significance and downstream mechanism remain unclear. Here, we found that miR-10b-3p was reduced in EBV-positive NPC tissues and was further suppressed following EBV infection of non-malignant nasopharyngeal epithelial cells and EBV-negative NPC cell lines. Restoration of miR-10b-3p expression markedly inhibited cell proliferation, colony formation, migration, invasion, and epithelial-mesenchymal transition (EMT) in EBV-positive NPC cells, whereas inhibition of miR-10b-3p in EBV-negative NPC cells produced the opposite effects. In nude mouse xenograft and lung metastasis models, overexpression of miR-10b-3p significantly reduced tumor growth and pulmonary metastasis. Mechanistically, miR-10b-3p directly targeted the 3'-UTR of integrin subunit alpha V (ITGAV), leading to decreased ITGAV expression and subsequent attenuation of STAT5 and ERK1/2 signaling. Forced ITGAV expression partially reversed the suppressive effects of miR-10b-3p on tumor cell proliferation, migration, invasion, and EMT. Moreover, miR-10b-3p levels were inversely correlated with ITGAV expression in NPC tissues. Collectively, these findings identify an EBV-regulated miR-10b-3p/ITGAV/STAT5-ERK1/2 axis in NPC and show that loss of miR-10b-3p promotes tumor growth and metastasis by relieving ITGAV repression, suggesting potential therapeutic targets for EBV-associated NPC. - Source: PubMed
Publication date: 2026/06/09
Zhang YuShi YaoqiangZou YingdongLi LiDian ZiqinChen YulingZhao HangWang JiajunSun Yi - Partly due to the inaccessibility of olfactory brain regions vulnerable to early Alzheimer's Disease (AD) for repeated sampling, proteomic networks underlying progressive cognitive decline remain poorly understood. The olfactory mucosa (OM), an accessible part of the olfactory system, reflects central nervous system physiology and pathology, and represents a promising site for biomarker discovery. This study aimed to identify olfactory proteomic markers and pathways associated with performance in the logical memory II recognition (LM II_recog) subtest of the Wechsler Memory Scale among older adults with subjective cognitive complaints. - Source: PubMed
Publication date: 2026/05/21
Sadhukhan TamalRai NarayanHipolito Maria Mañanita SShelby MyeshiaMejía Mondragón Claudia IvonneSadhukhan SriparnaIdowu AbimbolaVarghese Rency SSajid Muhammad SalmanRessom Habtom WKalejaiye AdedoyinObisesan Thomas OMisiak-Christian MagdalenaNwulia Evaristus A - The Epithelial‒Mesenchymal Transition (EMT) is correlated with poor prognosis in patients with Gastric Cancer (GC). Traditional EMT markers are quantified to identify the activated processes. However, these molecules are not universally present. Thus, identifying more representative EMT markers is important for a better understanding of the EMT process, metastasis, and the progression of GC. - Source: PubMed
Publication date: 2026/05/19
Han XuSun LishuangWang WentongLi WeiJia YunheNiu YangyangLiu BangquanLi XiaomeiTian Wenjing - Hepatocellular carcinoma (HCC) represents a major global health burden, characterized by complex metabolic reprogramming and immunological dysregulation. This study aimed to elucidate the molecular mechanisms underlying HCC progression using integrative multi-omics analyses, with a specific focus on macrophage heterogeneity and intercellular communication networks in the tumor microenvironment. - Source: PubMed
Publication date: 2026/05/18
Tang YiFeiLi JiaHuiHuang LingYing