Ask about this productRelated genes to: CD49e antibody
- Gene:
- ITGA5 NIH gene
- Name:
- integrin subunit alpha 5
- Previous symbol:
- FNRA
- Synonyms:
- CD49e
- Chromosome:
- 12q13.13
- Locus Type:
- gene with protein product
- Date approved:
- 1988-07-19
- Date modifiied:
- 2016-01-15
Related products to: CD49e antibody
Related articles to: CD49e antibody
- Head and neck squamous cell carcinoma (HNSCC) poses a significant global health challenge, accounting for approximately 4.5% of all malignancies, with approximately 890,000 new cases and 450,000 related deaths annually. Research indicates that partial epithelial-mesenchymal transition (p-EMT) figures prominently in the progression and metastasis of HNSCC. This study was conducted to determine whether the differentially expressed genes (DEGs) in HNSCC are key regulators of p-EMT. - Source: PubMed
Publication date: 2026/06/24
Liu ZhichangJia QiaojingYang ZhichaoZhang HaizhongWang JingmiaoLiu LishaLou DanWang Jianxing - This study aimed to evaluate the potential of Acer truncatum leaf extract (ATLE) to mitigate oxidative-stress-induced impairment of reproductive function in laying hens, with a focus on mechanisms involving antioxidant defense, angiogenesis, and ovarian microenvironment homeostasis. Oxidative stress was induced by tert-butyl hydroperoxide (tBHP) injection. Hens were randomly assigned to a control group (CON), an oxidative stress group (BCON), and an oxidative stress group supplemented with 0.6% ATLE (BATLE). Egg-laying performance, ovarian morphology, reproductive hormones, oxidative stress markers, and angiogenesis indicators were evaluated and integrated with transcriptomic analysis. The results were as follows: 1) Production and Morphology: ATLE supplementation alleviated (P < 0.05) the tBHP-induced decrease in egg laying rate and elevation in feed conversion ratio (FCR). It also mitigated (P < 0.05) reductions in the number of hierarchical follicles and the ovarian stroma index while restoring (P < 0.05) serum concentrations of LH and GH, thereby re-establishing reproductive endocrine balance. 2) Antioxidant Defense: ATLE activated (P < 0.05) Nrf2 and increased (P < 0.05) transcription of downstream antioxidant genes, including SOD3, GPX3, PRDX4, GSR and CAT, thereby enhancing (P < 0.05) the SOD and CAT activities and reducing (P < 0.05) MDA concentrations within both serum and ovarian tissues. 3) Vascular Network Support: ATLE attenuated (P < 0.05) the tBHP-induced downregulation of angiogenic factors, including protein levels of VEGF, ANGPT1, and HIF-1α and mRNA expression levels of VEGFA, ANGPT1, ANGPT2, ITGA5, and MMP9. 4) Microenvironment Remodeling: Transcriptomic integration revealed that ATLE-mediated repair overlapped (> 88%) with oxidative-stress-induced damage across functional modules. By reversing dysregulation of key genes such as VEGFA, KDR, and FN1, ATLE restored core pathways including focal adhesion and ECM-receptor interaction, and coordinated processes such as extracellular matrix, angiogenesis, and response to wounding, driving a systemic remodeling of the ovarian reproductive microenvironment toward homeostasis. In summary, this study demonstrated that ATLE activated multiple signaling axes, notably Nrf2 and VEGF. As a result, ATLE enhanced antioxidant defenses against oxidative damage and promoted vascular health and microenvironmental remodeling in the ovary. Together, these effects preserved the structural integrity and function of the laying hen reproductive system. These findings supported the potential of ATLE as a natural feed additive and provided a scientific rationale for using nutritional strategies to alleviate oxidative stress and improve reproductive health in laying hens. - Source: PubMed
Publication date: 2026/08/12
Qin KailongMa JunjieGao MingluLiu YanliYang Xiaojun - Wang et al. recently identified a novel post-translational mechanism in aortic dissection (AD) where DTX1 mediates ITGA5 ubiquitination to prevent vascular smooth muscle cell (VSMC) phenotypic switching. While their findings are robust, several mechanistic gaps remain. This letter expands on the functional implications of the ITGA5/ITGB1 heterodimer, proposes the involvement of deubiquitinases (DUBs) in rescuing ITGA5 from degradation, and explores the upstream epigenetic and inflammatory triggers of DTX1 downregulation. By integrating recent evidence on epigenetic modulators like SIRT1, we suggest that restoring upstream transcriptional regulators may offer more sustainable therapeutic outcomes than solely targeting downstream ITGA5 accumulation. - Source: PubMed
Publication date: 2026/08/11
Jin HuanpingXu Xiaomin - Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal malignancies and is characterised by aggressive biological behaviour, marked therapeutic resistance and a dense desmoplastic tumour microenvironment. Integrin α5β1, the principal fibronectin receptor, has emerged as an important mediator of tumour-stroma interactions through its roles in cell adhesion, mechanotransduction, migration, survival and extracellular matrix (ECM) remodelling. - Source: PubMed
Ma ChenzheWang YingyingLi Yumin - The heterogeneity in associations between circulating fatty acids (FA) and mortality remained underexplored. Proteomics can profile the human physiological status. This study aimed to estimate interactions between FA and proteins in relation to mortality. We randomly divided 30,190 UK Biobank participants into train and test datasets. Multivariable Cox regression was utilized to assess the associations between FA and all-cause mortality and to explore proteome-wide interactions of FA in relation to mortality. Subgroup analyses were conducted to examine heterogeneity across varied protein levels. We also explored interactions between proteins and FA in relation to cause-specific mortality. We documented 3,345 deaths during 13.9 years of follow-up. MUFA-pct, Non-LA Omega-6 pct, Omega-6/Omega-3 ratio and SFA-pct were positively associated with all-cause mortality, while PUFA-pct, DHA-pct, LA-pct, and Omega-3-pct were negatively associated. We identified several robust interactions of proteins with MUFA-pct (n = 3), Omega-3-pct (n = 4), and Omega-6/Omega-3 ratio (n = 2). In subgroup analyses, individuals with high-level TNFRSF1B, MMP10, and CRHBP had higher all-cause mortality risks associated with MUFA-pct, while protective associations between Omega-3-pct and all-cause mortality were stronger among individuals with high-level TSPAN8, PLAU, ITGA5, and CEACAM1. Moreover, participants with high-level TSPAN8 and PLAU had higher risks of all-cause mortality with Omega-6/Omega-3 ratio. For cause-specific mortality, interaction and subgroup results were largely consistent with those of all-cause mortality. Our findings can provide new insights into heterogeneity in FA-mortality associations and highlight potential protein targets for personalized interventions across individuals with different physiological status. - Source: PubMed
Publication date: 2026/08/10
Qiao ZiyanWang XinruTao ChengzheLiao SijingLu JiaweiYuan YitingXu QiaoqiaoFan YunWang XuLu Chuncheng