Ask about this productRelated genes to: CD49f antibody
- Gene:
- ITGA6 NIH gene
- Name:
- integrin subunit alpha 6
- Previous symbol:
- -
- Synonyms:
- CD49f
- Chromosome:
- 2q31.1
- Locus Type:
- gene with protein product
- Date approved:
- 1991-08-06
- Date modifiied:
- 2015-12-15
Related products to: CD49f antibody
Related articles to: CD49f antibody
- Non-small cell lung cancer (NSCLC) contains rare cancer stem cells (CSCs) that contribute to relapse and drug resistance. Bulk RNA-seq overlooks these cells due to its averaging of expression across all cell types, whereas standard single-cell RNA-seq (scRNA-seq) analyses often struggle to reliably identify these rare CSC states. To address this, we developed an scRNA-seq pipeline that integrates machine learning with explainable AI (XAI) to detect CSC-like epithelial cells in NSCLC (GSE198099, n = 2 patients; analyses supported by effect size-based validation despite limited statistical power). Patient-derived scRNA-seq profiles underwent quality control and batch correction using scVI, and annotated using CellTypist. A 45-gene stemness score was used to identify candidate CSC-like states. Four machine learning models (Logistic Regression, LightGBM, XGBoost, and CatBoost) were trained to refine the CSC-like state identification. SHAP-based feature attribution analyses converged on six key biomarkers: DLL1, ITGA6, ATXN2, NOTCH1, DCLK1, and PUM1. These biomarkers are involved in regulating transcription, adhesion, cytoskeletal dynamics, and post-transcriptional control. Pathway analysis and validation using TCGA validation data provided supportive evidence for the biological relevance of these biomarkers. This framework provides a methodologically reproducible approach to reveal rare CSC-like states with improved mechanistic clarity, providing candidate biomarkers for studying NSCLC tumor plasticity. - Source: PubMed
Publication date: 2026/04/22
Munisankar SharathKumar RThiyagaraj Anand - Unicentric Castleman disease (UCD), a rare lymphoproliferative disorder, is frequently complicated by paraneoplastic pemphigus (PNP), an autoimmune mucocutaneous syndrome with high mortality. The hyaline-vascular (HV) histological subtype predominates in UCD-PNP, yet the mechanisms driving vascular hyalinization and stromal dysregulation remain poorly defined. - Source: PubMed
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Wang SaiWang RuiYang YinmoDong YujunShang PanpanChen XixueZhu XuejunWang YangZhang GuohongWang Mingyue - The ovary is a central female reproductive organ responsible for producing oocytes and secreting steroid hormones. To investigate the molecular similarities and potential evolutionary origins of the ovary across vertebrates, we integrated publicly available single-cell and single-nucleus transcriptomic data from nine species, including oviparous animals (fish and chicken) and viviparous mammals (mouse, rat, sheep, goat, yak, monkey, and human). - Source: PubMed
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Xue BailingLiu YajingZhou ChenDossybayev KairatBaatar NarantuyaYudin NikolayZhang LinweiYang JiLi MenghuaXu Songsong - Periodontitis manifests as dysregulated epithelial-stromal interactions and resultant tissue destruction, yet the regulatory mechanisms of the pivotal hemidesmosomes after periodontitis treatment remain elusive. - Source: PubMed
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Zhang YulongWu XingXu FeiSong QianhuiLi ZhaofenZhen WenyuWang RuiSheng ZiwenSun WansuXu JianguangWang HaitaoZhang Hengguo - There is an urgent need for the development of innovative diagnostic and therapeutic strategies in bladder cancer (BlCa) management, due to its significant incidence, mortality, and morbidity. Extracellular vesicles (EVs) constitute promising candidates as biomarkers, as their cargo is highly protected from degradation, and they can be isolated non-invasively from urine. Furthermore, they play a pivotal role in intercellular communication that drives disease progression, making them suitable candidates for tailored therapy approaches. - Source: PubMed
Publication date: 2026/04/09
Lourenço CatarinaConstâncio VeraTavares Nuno TiagoMonteiro-Reis SaraSilva-Santos RuiLobo JoãoCarvalho ÂngelaJerónimo Carmen