Ask about this productRelated genes to: CD62E antibody
- Gene:
- SELE NIH gene
- Name:
- selectin E
- Previous symbol:
- ELAM1, ELAM
- Synonyms:
- ESEL, CD62E
- Chromosome:
- 1q24.2
- Locus Type:
- gene with protein product
- Date approved:
- 1989-06-30
- Date modifiied:
- 2015-08-25
Related products to: CD62E antibody
Related articles to: CD62E antibody
- Human milk oligosaccharides (HMOs) are the third most abundant solid component in human milk and contribute to infant gut microbiota development, immune maturation, and neurodevelopment. Their composition varies according to genetic factors, particularly maternal Secretor and Lewis phenotypes, as well as lactation stage. However, comprehensive data on longitudinal HMO profiles and genetic phenotypes in Japanese mothers remain limited. This study aimed to characterize longitudinal HMO profiles in Japanese mothers at three lactation stages, classify samples into four Secretor/Lewis groups, and exploratorily evaluate differences associated with maternal and infant characteristics. - Source: PubMed
Publication date: 2026/05/28
Higuchi NaokoSawane KentoHara ChisatoKoshizaka MasayaYamamoto MidoriTakumi HirokoSakurai Kenichi - Following ischemic stroke, neutrophil adhesion to activated cerebral endothelium triggers the initial inflammatory cascade. Real-time, quantitative in vivo detection of this early interaction could help identify individuals most likely to benefit from immunomodulatory therapies. To achieve this, we analyzed single-cell RNA sequencing data from brain tissue and identified E-selectin (Sele) as one of the earliest adhesion molecules selectively upregulated in activated endothelial cells with a venous-like transcriptional signature. We then developed iron oxide microparticles targeting E-selectin, designed to mimic neutrophil adhesion and to function as MRI probes for early endothelial activation. Within seconds of injection, these probes adhered to inflamed vessels in models of LPS-induced neuroinflammation and ischemic stroke, allowing rapid emergency imaging. We observed an MRI-detectable signal as early as 4 h following LPS stimulation and 8 h post-stroke. This binding was significantly associated with neutrophil infiltration, but not with lesion volume, blood-brain barrier disruption, or the accumulation of T cells and monocyte-derived cells. These findings demonstrate its specificity for neutrophil-driven inflammation and its relevance as a biomarker of ultra-early immune activation. These results suggest that neutrophil-mimetic MRI probes could represent a promising approach for detecting the initial phase of stroke-induced inflammation and for guiding personalized immunomodulatory strategies. - Source: PubMed
Publication date: 2026/06/08
Morvan Marion IsabelleLevard DamienLemarchand EloïseBoublay AmalHelaine CharlyMalherbe JolanNaveau MikaëlGoux DidierKhalin IgorTalukdar AnkitaPelleter CheunJacqmarcq CharlèneBaudron ErwanBardou IsabelleMartinez de Lizarrondo SaraGauberti MaximeVivien DenisFournier Antoine Philippe - Temozolomide (TMZ) is used to treat glioblastoma cancer and it is essential to identify key genes and investigate the molecular mechanisms of glioblastoma cancer cells resistant to temozolomide. - Source: PubMed
Publication date: 2026/06/05
Alamholo MostafaTarinejad Alireza - Objectives - To develop and independently validate risk-prediction models for three common urological conditions based on a combination of simple, minimally-invasive index tests in men with lower urinary tract symptoms (LUTS) presenting to primary care. Design - A prospective, multicentre, diagnostic accuracy study with independent development and validation cohorts. Setting - 67 general practices in England and Wales. Participants - 601 men presenting to primary care with LUTS: 350 in the development cohort and 251 in the validation cohort. Interventions -Index tests - validated symptom assessment, bladder diary, physical examination, serum prostate specific antigen, uroflowmetry and post-void residual volume estimation. Invasive urodynamic studies provided a diagnostic reference standard. Risk prediction models were developed and validated in independent cohorts. Main outcome measures - Discriminative and calibration performance of the risk prediction models for diagnosing bladder outlet obstruction (BOO), detrusor underactivity (DU) and detrusor overactivity (DO) using the c-index, calibration slope and plot and sensitivity and specificity of the models. Results - The BOO model from the development cohort demonstrated good discriminative performance (optimism-corrected c-index of 0.80). The models derived from the development cohort for DU and DO demonstrated moderate discriminative ability (optimism-corrected c-indices of 0.64 and 0.67 respectively). Similar estimates of c-index were observed for each model within the independent validation cohort (BOO=0.82, DU= 0.63 and DO =0.62).. Conclusions - Using a combination of simple, non-invasive index tests can accurately predict common urological diagnoses in men with LUTS, potentially facilitating earlier initiation of evidence-based treatments and improved management in primary care. - Source: PubMed
Publication date: 2026/06/04
Harding ChrisAgarwal RidhiBates JanineBray AlisonMilosevic SarahThomas-Jones EmmaDrinnan MichaelDrake Marcus JMichell PeterPell BethanAhmed HaroonJoseph-Williams NatalieSchatzberger TomDavies JaneHood KerenzaTakwoingi YemisiEdwards Adrian - Premature ovarian insufficiency (POI) is a complication that affects 80% of females with classic galactosemia (CG), an autosomal recessive metabolic disorder caused by mutations in the GALT gene. The immune system plays a critical role in normal ovarian physiology and in the development of pathological conditions, including POI. While previous animal studies have shown that accumulation of toxic galactose metabolites trigger cellular stress pathways, and may contribute to the disease's complications, it remains unclear how these influence the ovarian immune landscape in CG patients. - Source: PubMed
Publication date: 2026/05/30
Kavarthapu RaghuveerVo SonHanby NatalieVanpouille ChristopheBrunette MargaretSoliman Mary EPham ThangLou HongSierra Maria DeLa LuzMaher Jacqueline C YanoGomez-Lobo Veronica