Ask about this productRelated genes to: CD62E antibody
- Gene:
- SELE NIH gene
- Name:
- selectin E
- Previous symbol:
- ELAM1, ELAM
- Synonyms:
- ESEL, CD62E
- Chromosome:
- 1q24.2
- Locus Type:
- gene with protein product
- Date approved:
- 1989-06-30
- Date modifiied:
- 2015-08-25
Related products to: CD62E antibody
Related articles to: CD62E antibody
- International Classification of Diseases (11th ed.; ICD-11) Complex Posttraumatic Stress Disorder (CPTSD) is a new diagnostic category consisting of PTSD and disturbances of self-organization (DSO) symptoms. This study compares the trajectories of ICD-11 PTSD and DSO symptoms change in three treatments: a phase-based intervention, STAIR Narrative Therapy (SNT), Prolonged Exposure (PE), and skills-training in affect and interpersonal regulation (STAIR). Ninety-two adult patients with ICD-11 CPTSD following childhood abuse were randomly assigned to treatment conditions. Piecewise latent curve models of self-reported symptoms were used to compare the change trajectories. Piece 1 corresponds to phase 1 (SNT) and active treatment (PE/STAIR), and piece 2 corresponds to phase 2 (SNT) and the first two months after treatment (PE/STAIR). In piece 1, PTSD symptom decline was steeper in PE compared to skills-training yielding a difference of d = -0.66, 95% CI [-0.99, -0.32] compared to SNT, and d = -0.56, 95% CI [-0.90, -0.23] compared to STAIR. In piece 2, PTSD symptom decline accelerated in SNT compared to PE, d = -0.25, 95% CI [-0.05, -0.45], but not compared to STAIR. The rate of DSO symptoms decline did not differ among conditions during treatment but decelerated more in PE compared to STAIR after treatment, d = -0.30, 95% CI [-0.08, -0.51]. Trauma-focused interventions may be the preferable treatment approach for PTSD symptoms and comparable to skills-training in reducing DSO symptoms during treatment. Compared to trauma-focused interventions there may be a potential spillover effect of skills-training on DSO symptoms in daily life after treatment. - Source: PubMed
Publication date: 2026/04/21
Sele PeterHoffart AsleHembree ElizabethØktedalen Tuva - Ovarian cancer is the most lethal gynecological malignancy worldwide, largely due to late diagnosis and lack of effective population-level screening tools. Inflammatory cytokines regulate proliferation, apoptosis, angiogenesis, and immune surveillance, making inherited variation in cytokine pathways biologically plausible determinants of ovarian cancer susceptibility and progression. Since the early 2000s, numerous candidate-gene studies have evaluated polymorphisms of genes such as the interleukin () families, tumor necrosis factor alpha (), transforming growth factor beta 1 (), and components of the nuclear factor kappa B () signaling pathway and adhesion pathways, across diverse populations. In this review, we summarize these potential markers to give readers an overview showing accumulated evidence supports a coherent model in which genetically modulated inflammation is an integral driver of epithelial ovarian carcinogenesis. Collectively, studies reveal recurrent patterns of risk-increasing and risk-protective variants. Risky genotypes predicted to enhance pro-inflammatory, pro-angiogenic, or immunosuppressive signaling include rs16944 CC, rs1800795, rs2227306 TT, rs1126647 TT, rs11556218 GT/GG, rs4778889 CT/CC, rs10889677 AC/CC, rs4758680 CA/AA, rs28372698 TT, rs1800629 GA/AA, and peroxisome proliferator-activated receptor gamma () rs1801282 CG genotypes. Conversely, protective variants tend to dampen inflammatory tone or rebalance cytokine networks, including rs17561 GT/TT, rs4848300 CT/CC, rs3783553 insertion/insertion, rs7596684 CT/CC, rs1880242 GT/TT, rs7977932 CG/GG, rs1800469 CT/TT, selectin E () rs5361 AC, intercellular adhesion molecule 1 () rs5498 AG genotypes and specific haplotypes. Beyond risk , several polymorphisms appear predictive of clinical features, including tumor stage, cytoreductive resectability and recurrence, highlighting potential prognostic relevance. Notably, associations are often population-specific, reflecting differences in allelic frequencies and linkage disequilibrium across ethnic groups, underscoring the need for cross-ethnic replication. Further investigations may ultimately enable further improved the prevention, early detection, and personalized management of ovarian cancer. - Source: PubMed
Chang Wen-ShinTsai Chia-WenChen Jaw-ChyunWang Yun-ChiBau DA-Tian - The increasing interest in seaweed as a potential feed and food source has prompted concerns regarding the presence of potentially toxic arsenic (As) species. Seaweed is known to contain the organic As species arsenosugars, but the toxicity of these compounds is not fully known due to a lack of scientific data. Nori (Porphyra spp.), a common red seaweed and potential feed and food candidate, contains arsenosugar-phosphate (As-Sug-PO) as a primary As species. In this study, As-Sug-PO was isolated from nori by solid-phase extraction (SPE) and subsequently evaluated for in vitro toxicity in primary salmon hepatocytes. The As-Sug-PO isolate, alongside As reference standards (arsenite As(III) and dimethylarsinic acid (DMA(V)), and arsenic-containing hydrocarbon (AsHC-360)), were assessed for cytotoxicity (mitochondrial activity) and for transcriptional effects on genes associated with lipid biosynthesis, inflammation and oxidative stress by reverse transcription-quantitative polymerase chain reaction (RT‑qPCR). Impacts on total As and As speciation were quantified in both cell pellets and culture medium using high-performance liquid chromatography (HPLC) coupled to inductively coupled plasma mass spectrometry (ICP-MS). High concentrations of As-Sug-PO caused cytotoxicity and mitochondrial damage, while lower levels influenced triglyceride biosynthesis, indicating impaired lipid deposition. As(III) was the most toxic As species, followed by As-Sug-PO and DMA(V) and unlike As(III), As-Sug-PO and DMA(V) did not alter total As levels and speciation profile in samples after 48 h of exposure. Follow-up in vivo studies with commercial standards are needed to confirm effects on lipid deposition and to support the establishment of regulatory limits for As-Sug-PO in feed and food. - Source: PubMed
Publication date: 2026/04/02
Ghazali MohammadSele VeronikaSahuquillo AngelesMorales-Rodríguez AlbaSilva Marta SofiaLópez-Sánchez Jose FerminDonald CareyBerntssen Marc H GSøfteland Liv - Kashin-Beck disease (KBD) primarily impairs the epiphyseal plate in children and adolescents, resulting in enlarged bone ends and short stature. Given the abundance of type H vessels in the growing epiphyseal plate, this spatiotemporal correlation prompted us to investigate their potential role in KBD. - Source: PubMed
Publication date: 2026/04/16
Wan XufengDu HaoZhang YaoCai YongruiChen AnjingLiu XiaoyangSu QiangChen XumingDu ZeChen YangmengfanTang HaiweiZhou XinranWang DuanZhou Zongke - Both personality traits and personality disorders have been linked to suicide risk in youth. The DSM-5 Alternative Model of Personality Disorders (AMPD) allows dimensional assessment of personality pathology, which may enhance prediction of suicide attempts. A recent study found that personality dysfunction (Criterion A of the AMPD) is associated with past suicide attempts in adolescents. Building on this, the present study aimed to investigate the longitudinal relationship between AMPD personality pathology and suicide attempts in adolescents. - Source: PubMed
Publication date: 2026/04/15
Zippert Lea KassandraHertel ChristianSele SilvanoReichl CorinnaCavelti MarialuisaKoenig JulianKaess Michael