Mouse CD80 ELISA Kit
- Known as:
- Mouse CD80 Enzyme-linked immunosorbent assay test Kit
- Catalog number:
- 55r-1739
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Fitzgerald industries international
- Gene target:
- Mouse CD80 ELISA Kit
Related genes to: Mouse CD80 ELISA Kit
- Gene:
- CD80 NIH gene
- Name:
- CD80 molecule
- Previous symbol:
- CD28LG, CD28LG1
- Synonyms:
- B7.1, B7-1
- Chromosome:
- 3q13.33
- Locus Type:
- gene with protein product
- Date approved:
- 1993-12-14
- Date modifiied:
- 2016-10-05
Related products to: Mouse CD80 ELISA Kit
Related articles to: Mouse CD80 ELISA Kit
- To explore the effect and mechanism of pomalidomide on the immune activity of dendritic cell-derived exosomes (DEXs) from patients with multiple myeloma (MM). - Source: PubMed
Publication date: 2026/06/19
Zhang HuWang YifanWang XueqingDuan HailingYu DuonanKuang XiaochuanHe LinZhang WenyiChen JieDai Jingying - Tuberculosis (TB) remains a major global health burden, and Bacille Calmette-Guérin (BCG) provides inconsistent protection against adult pulmonary disease. Adjuvant strategies to enhance BCG efficacy are urgently needed. Here we show that whole β-glucan particles (WGP) enhance BCG-induced immune responses and improve protection against mycobacterial challenge. In vitro, WGP enhances macrophage functions associated with antigen processing during BCG exposure, including phagocytosis, lysosomal acidification, intracellular degradation, and the upregulation of MHC-II/CD80/CD86. WGP co-exposure partially attenuates the early IL-10 response induced by BCG. Mechanistically, whole β-glucan particles activate the Dectin-1-JAK1-STAT1 pathway, and disruption of this axis reduces MHC-II upregulation and impairs macrophage-supported OT-II CD4 T-cell proliferation and IFN-γ production. In vivo, using female wild-type and Dectin-1 knockout C57BL/6 J mice, we find that split-site administration of WGP and BCG is better tolerated than same-site mixing and is associated with a less inflammatory early pulmonary myeloid profile. Under this optimized regimen, WGP plus BCG enhances CD4 memory-associated responses and improves bacterial control while reducing lung inflammation in a Mycobacterium tuberculosis H37Ra challenge model. These findings support further evaluation of WGP as an adjunct candidate for BCG-based vaccination strategies and may inform the development of improved tuberculosis vaccines. - Source: PubMed
Publication date: 2026/06/17
Cao YigeQu HaoranTian QingSun SujuanZhang WenwenFang DanChen PinruZhao ChenyuZhang Xiao-LianPan QinLuo FenglingLiu Min - The present study aimed to investigate the role of macrophages in regulating intestinal epithelial barrier integrity during the early stages of Eimeria tenella infection in chickens. The intestinal mucosal barrier, comprising tight junction proteins and mucus-producing goblet cells, plays a critical role in protecting against pathogen invasion. However, the influence of innate immune cells, particularly macrophages, on mucosal barrier components during coccidial infection remains unclear. To examine this, chicks were treated with ι-carrageenan to induce suppression of macrophage-associated responses during E. tenella infection. This was supported by the reduced expression of macrophage markers (MHC-II and CD80) in the spleen, cecal tonsils, and cecum. Histopathological analysis revealed that the ι-carrageenan-treated chicks exhibited significantly lower lesion scores than the infected controls. Notably, the goblet cell numbers were better preserved in the ι-carrageenan-treated chicks, whereas the infected controls showed a marked reduction in the number of goblet cells at 3 and 5 days post-infection. Gene expression analysis demonstrated elevated levels of pro-inflammatory cytokines (interleukin-1β and interferon-γ) and inducible nitric oxide synthase in the infected controls, indicating enhanced inflammatory responses. Contrarily, inhibition of macrophage-related responses attenuated inflammatory signaling in the ι-carrageenan-treated group. Additionally, increased expression of MUC5AC and SAM pointed domain containing ETS transcription factor (SPDEF) were observed in the ι-carrageenan-treated chicks, suggesting enhanced goblet cell-associated responses in the mucosal barrier. Overall, these findings suggest that modulation of macrophage-associated responses is associated with preservation of goblet cells and attenuation of barrier-related pathological changes during E. tenella infection. - Source: PubMed
Publication date: 2026/06/16
Dong Rin HuuMatsubayashi MakotoHatabu Toshimitsu - Colorectal cancer (CRC) is a highly prevalent and lethal digestive system malignancy worldwide, which mostly develops through a multi-step progression from normal mucosa to adenoma and finally invasive carcinoma. Lack of specific biomarkers for precancerous lesions limits early screening and intervention efficacy. This study aimed to investigate the differential expression of Dickkopf-related protein 4 (DKK4) in CRC and its correlation with clinicopathological features, and to construct a DKK4-based risk prediction model for CRC. - Source: PubMed
Publication date: 2026/05/27
Wang XiaoxiongShan MinghaiQiao XiaDing LuYang JialiHe FangMian YushenZhang XuYang Shaoqi - Sepsis is characterized by dysregulated inflammatory responses triggered by pathogen-associated molecular patterns (PAMPs) and remains a major cause of mortality worldwide. Although antibiotics are widely used for the treatment of sepsis-associated infections, their clinical efficacy is often limited by antimicrobial resistance and the inability to control excessive inflammatory responses. Indolicidin is a bovine-derived antimicrobial peptide with antimicrobial and immunomodulatory activities; however, its anti-inflammatory mechanisms in sepsis remain unclear. In this study, we investigated the protective effects and mechanisms of indolicidin in bacterial and fungal sepsis models. The results showed that indolicidin exhibited good biocompatibility both in vitro and in vivo. In murine models of - and -induced sepsis, indolicidin significantly improved survival and reduced microbial burden in the kidneys. In RAW264.7 macrophages stimulated with lipopolysaccharide (LPS), a major PAMP of , indolicidin suppressed M1 polarization, reactive oxygen species production, and proinflammatory cytokine expression. Transcriptomic analyses of macrophages and infected kidney tissues revealed that indolicidin consistently downregulated inflammation-related pathways, chemokine signaling, and LPS-response pathways, including genes associated with IL-6, chemokines, and M1 macrophage markers such as CD80 and CD86. Mechanistically, indolicidin directly bound LPS, interacted with lipopolysaccharide-binding protein (LBP), and reduced the surface expression of CD14 and the TLR4/MD2 complex, indicating modulation of the TLR4 signaling pathway. Overall, this study highlights indolicidin as a dual-function peptide with antimicrobial and immunomodulatory activity and supports its potential as a therapeutic candidate against sepsis. - Source: PubMed
Publication date: 2026/06/17
Shi ZhishangWang YantingGu YijunZhu MengsenLi MingchunYu Qilin