Human EGVEGF ELISA Kit
- Known as:
- Human EGVEGF Enzyme-linked immunosorbent assay test Kit
- Catalog number:
- 55r-1712
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Fitzgerald industries international
- Gene target:
- Human EGVEGF ELISA Kit
Related genes to: Human EGVEGF ELISA Kit
- Gene:
- PROK1 NIH gene
- Name:
- prokineticin 1
- Previous symbol:
- -
- Synonyms:
- PK1, PRK1, EGVEGF
- Chromosome:
- 1p13.3
- Locus Type:
- gene with protein product
- Date approved:
- 2002-07-22
- Date modifiied:
- 2016-10-05
Related products to: Human EGVEGF ELISA Kit
Related articles to: Human EGVEGF ELISA Kit
- Although exercise can help prevent age-related cognitive decline, the mechanisms underlying its effects on cognition, immune function remain unclear. Therefore, this study comprehensively examined the effects of circuit training on cognitive function, and the plasma proteome in middle-aged to older women. - Source: PubMed
Publication date: 2026/06/23
Soga KeishiTakahashi MichioOba KentaroUno AkariKawamura TakujiKawashima KeiseiShinada TakamitsuTaki Yasuyuki - The impact and mechanisms of PROK1 on macrophages in pancreatic cancer (PC) progression was investigated. PROK1 and PROKR2 expression in PC patients were detected by immunohistochemistry and Western blot. TIMER database analyzed correlation between PROK1/PROKR2 and macrophage infiltration in PC. PROK1 influence on macrophage M2 phenotypic conversion and PI3K/AKT pathway activity were investigated by detecting CD206, IL-10, Arg-1, p-PI3K/PI3K and p-AKT/AKT via immunofluorescence and Western blot. PROK1 in macrophages on viability, migration and invasion of PC cells was appraised by CCK-8, wound healing and Transwell assays. Immunoprecipitation verified the interaction between PROK1 and PROKR2. Western blot explored regulation of PROK1 and PROKR2 on PI3K/AKT pathway activity and macrophage M2 phenotypic conversion. In vivo study was executed by constructing xenograft tumor models. PROK1 and PROKR2 overexpression in PC patients was associated with macrophage infiltration, advanced TNM stage, lymph node and distant metastasis. PROK1 silencing suppressed macrophage M2 phenotypic conversion and PI3K/AKT pathway activity, as it reduced CD206, IL-10, Arg-1, p-PI3K/PI3K, and p-AKT/AKT. PROK1 silencing in M2 macrophages attenuated PC cell viability, migration and invasion. PROK1 interacted with PROKR2 to activate PI3K/AKT pathway in macrophages. PROK1 elevated CD206, IL-10 and Arg-1 in M2 macrophages, which was reversed by PROKR2 silencing. In vivo, PROK1 in macrophages enhanced PC growth and expression of CD206, IL-10, Arg-1, p-PI3K/PI3K and p-AKT/AKT in xenograft tumors, which was abrogated by PROKR2 silencing. PROK1 induced macrophage M2 phenotype conversion to promote PC progression by activating the PI3K/AKT pathway via interacting with PROKR2. - Source: PubMed
Publication date: 2026/06/22
Ma LanYan XiaogangLiu DiBu WenpingKang FupingHui YongfengSong JianjunWang Feng - Prokineticin 1 (PROK1), known as endocrine gland-derived endothelial growth factor (EG-VEGF), is a key regulator of pregnancy, playing various roles from implantation to birth. We have shown that maternal serum concentrations of PROK1 are highest during the first trimester and are elevated in pregnancy complications such as spontaneous preterm birth (sPTB). Additionally, PROK1 is described as being largely expressed by the chorion in fetal membranes, suggesting its presence in amniotic fluid. Despite these findings, no information is available about PROK1 concentrations in the amniotic fluid, nor concerning its evolution in the context of spontaneous preterm labor with or without infection. - Source: PubMed
Publication date: 2026/06/23
Desseux MorganeRaia-Barjat TiphaineRomero RobertoHoffmann PascaleMeyyazhagan ArunAwonuga Awoniyi OChaiworapongsa TinnakornBenharouga MohamedAlfaidy Nadia - Recurrent implantation failure (RIF) is a major challenge in reproductive medicine. This study explores the expression profiles and interactions of progesterone receptor B (PGR-B), prokineticin 1 (PROK1), prokineticin receptor 1 (PROKR1), and their regulatory associations with microRNA-210-5p (miR-210-5p) and long non-coding RNA H19 (lncRNA-H19) within endometrial tissue. This case-control study was conducted from June 2021 to July 2023, involving 50 patients with recurrent implantation failure (RIF) and a control group of 50 women with successful term pregnancies. Participants were recruited from Arash Hospital in Tehran, Iran. Hysteroscopic assessments were done for the RIF group, while the control group had sampling via Pipelle catheter. We measured the expression levels of key molecular markers, including PGR-B, PROK1, PROKR1, lncRNA-H19, and miR-210-5p, using quantitative real-time PCR (qRT-PCR). Our findings demonstrate significantly low expression and protein levels of PGR-B and PROK1, suggesting a potential dysregulation of these biomolecules in the studied context. Notably, we observed a strong positive correlation between PGR-B and PROKR1, suggesting a synergistic regulatory relationship, potentially influencing endometrial signaling pathways. Conversely, in fertile women, PGR-B and PROK1 exhibited a positive correlation with miR-210-5p, implicating miR-210-5p as a potential activator of PGR-B downstream pathways. Additionally, a positive correlation between PGR-B and PROK1 with lncRNA-H19 was identified, hinting at a complex regulatory network involving these non-coding RNAs. Our findings indicated that a regulatory network involving PGR‑B, PROK1, PROKR1, lncRNA‑H19, and miR‑210‑5p in women with RIF. The significant correlation between these molecules underscores the importance of angiogenesis, a novel mechanistic link to impaired decidualization and endometrial receptivity. It provides new insight into the molecular basis of implantation failure. - Source: PubMed
Publication date: 2026/06/08
Rostami RahimJahanbakhsh JamilehSalehi ShirinAsgari KatayoonFallah Soudabeh - Prokineticin-1 (PROK-1), known as endocrine gland-derived vascular endothelial growth factor, is an angiogenic peptide mostly produced in endocrine and placental organs. It is important for placental vascular remodeling and trophoblast control. This study sought to investigate the potential of maternal serum PROK-1 levels as a diagnostic or prognostic marker in preeclampsia (PE). - Source: PubMed
Ayas Özkan MerveKından AzizAslanlı İslamYakut Yücel Kadriye