Mouse IL12 ELISA Kit (p70)
- Known as:
- Mouse IL12 Enzyme-linked immunosorbent assay test Kit (p70)
- Catalog number:
- 55r-1626
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Fitzgerald industries international
- Gene target:
- Mouse IL12 ELISA Kit (p70)
Related genes to: Mouse IL12 ELISA Kit (p70)
- Gene:
- IL12RB1 NIH gene
- Name:
- interleukin 12 receptor subunit beta 1
- Previous symbol:
- IL12RB
- Synonyms:
- CD212
- Chromosome:
- 19p13.11
- Locus Type:
- gene with protein product
- Date approved:
- 1995-09-14
- Date modifiied:
- 2019-04-23
- Gene:
- NSRP1 NIH gene
- Name:
- nuclear speckle splicing regulatory protein 1
- Previous symbol:
- CCDC55
- Synonyms:
- DKFZP434K1421, NSrp70
- Chromosome:
- 17q11.2
- Locus Type:
- gene with protein product
- Date approved:
- 2006-01-12
- Date modifiied:
- 2014-11-18
- Gene:
- RPS6KB1 NIH gene
- Name:
- ribosomal protein S6 kinase B1
- Previous symbol:
- STK14A
- Synonyms:
- S6K1, p70(S6K)-alpha, PS6K, S6K
- Chromosome:
- 17q23.1
- Locus Type:
- gene with protein product
- Date approved:
- 1994-07-11
- Date modifiied:
- 2018-04-18
- Gene:
- RPS6KB2 NIH gene
- Name:
- ribosomal protein S6 kinase B2
- Previous symbol:
- -
- Synonyms:
- p70S6Kb, P70-BETA, STK14B, KLS, S6KB, S6Kbeta, S6Kβ
- Chromosome:
- 11q13.2
- Locus Type:
- gene with protein product
- Date approved:
- 1994-07-13
- Date modifiied:
- 2018-04-18
Related products to: Mouse IL12 ELISA Kit (p70)
Related articles to: Mouse IL12 ELISA Kit (p70)
- Mendelian Susceptibility to Mycobacterial Disease (MSMD), caused by IL12RB1 or IL12B mutations, typically presents with intra-cellular infections such as BCG-adenitis or Salmonella. Rarely, patients with IL12RB1/IL12B defects can exhibit cutaneous manifestations like Henoch-Schonlein purpura (HSP). This study aimed to evaluate such vasculitic manifestations in genetically confirmed cases with MSMD in India and review the literature for similar associations. - Source: PubMed
Publication date: 2026/06/29
Sharma YaminiNadig PallaviDas JhumkiIyengar VaishnaviLoganathan Satish KumarChougule AkshayaGowri VijayaTaur PrasadPilania RakeshDhaliwal ManpreetSharma SaniyaChatterjee DebajyotiSuri DeeptiDesai MukeshSingh SurjitVignesh PandiarajanRawat Amit - encodes a pivotal component of the IL-23/Th17 signaling axis and represents a validated genetic susceptibility locus for inflammatory bowel disease (IBD), psoriasis, and ankylosing spondylitis. Despite extensive GWAS data, the functional consequences of the full spectrum of missense single-nucleotide variants (SNVs) have not been systematically characterized. This study aimed to identify high-risk missense SNVs through a multi-tool in silico pipeline. - Source: PubMed
Publication date: 2026/06/16
Altintas Kazar Gamze - TB meningitis (TBM) has up to 50% mortality in people living with HIV. We investigated differences in cerebrospinal fluid (CSF) host immune responses associated with short-term mortality. - Source: PubMed
Publication date: 2026/06/18
Louine MartineauDandekar RaviReddy Sumanth PKaralius Mary CWaldrop GreerWang ShiyinGakuru JaneKimuda SarahMugabi TimothyMusubire Abdu KKagimu EnockAbassi MahsaKabahubya MableWilliams Darlisha APhan Hoang VanDai BiyueZia MahamZorn Kelsey CFouassier CamilleGerungan ChloeMarra Pedro SSkipper Caleb PBahr Nathan CLangelier Charles RCreswell Fiona VBoulware David RMeya David BWilson Michael R - Mendelian susceptibility to mycobacterial disease (MSMD) is a rare syndrome characterized by increased and selective susceptibility to weakly virulent mycobacteria and other intramacrophagic pathogens. This study emphasizes the utility of immunological and functional assays in diagnosing MSMD by analyzing clinical, immunological, and genetic features in 50 Indian patients. Immunological workup included lymphocyte subset analysis, nitroblue tetrazolium test (NBT), and flow cytometric assessment of IFN-γR1 (CD119), IL-12Rβ1 (CD212), and phosphorylated STAT1/STAT4 following cytokine stimulation. Functional assays measured IFN-γ and IL-12p70 production. Genetic evaluation was performed using whole-exome or Sanger sequencing. The median age at onset was 3 mo. BCG complications were the most common presentation (96%), while 4% had non-tuberculous mycobacterial infections. Additional infections included , spp., spp., and multiple types of viruses. IL-12Rβ1 deficiency was the most frequent diagnosis, with 10 novel variants in the gene identified. These results demonstrate that combining flow cytometry with functional and genetic analyses enables accurate and timely MSMD diagnosis. - Source: PubMed
Publication date: 2025/12/18
Dalvi AparnaTemkar LavinaDesai MukeshGarg SwatiAluri JahnaviHule GouriBargir Umair AhmedSetia PriyankaKambli PriyankaDhawale AmrutaTamhankar ParagYadav Reetika MalikBhattad SagarSivasankaran MeenaLashkari Harsha PrasadKacha AsrutiBharathi T KasiKanakia SwatiGandhi Kamana ArunShelar ShraddhaShinde ShwetaJodhawat NehaKawale RameshSalve NitinCasanova Jean-LaurentBustamante JacintaMadkaikar Manisha R - Mendelian susceptibility to mycobacterial disease (MSMD) is characterized by increased susceptibility to infections caused by weakly virulent mycobacteria (such as nontuberculous mycobacteria (NTM) or the Bacillus Calmette–Guérin (BCG) vaccine) in otherwise healthy individuals. In this study, we described a 29-year-old patient with MSMD due to NTM infection identified using metagenomic next-generation sequencing (mNGS) testing. The patient showed a poor response to standard antimycobacterial treatment. Therefore, we performed whole-exome sequencing (WES) and identified three heterozygous variants in IL-12Rβ1 (Ala131Thr, Arg323* and Arg561*). The two deleterious IL-12RB1 variants, Arg323* and Arg561*,were shown to be in trans (paternal and maternal, respectively). Further investigation revealed that two of these variants (Arg323* and Arg561*) could affect the binding between IL-12Rβ1 and IL-12Rβ2, leading to a weakened response of CD4+ T cells to stimulation with IL-12 plus tuberculosis antigen (TbAg), with reduced expression levels of IFN-γ and its downstream target p-STAT4. However, these variants did not affect the CD4+ T-cell response to glucan stimulation, as the three heterozygous variant loci do not interfere with the aggregation of IL-12Rβ1 and IL-23R. This autosomal recessive, partial IL-12Rβ1 deficiency ultimately resulted in the patient developing disseminated NTM infection. In clinical treatment, we combined IFN-γ with standard antimycobacterial therapy. The patient showed only a partial response to therapy. Therefore, as detection techniques continue to advance, it is important for clinicians to increase their understanding of MSMD to enable faster and more accurate diagnosis and treatment. - Source: PubMed
Publication date: 2026/04/21
Chen JinmeiXi MinHu WeiweiHe RongliZhang WenruiZhang YiChen XiaohuaChen Jie